INT113864

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Context Info
Confidence 0.36
First Reported 2003
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.38
Pain Relevance 1.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (ABCC2) ATPase activity (ABCC2) plasma membrane (ABCC2)
transmembrane transport (ABCC2)
Anatomy Link Frequency
2B5 3
ABCC2 (Homo sapiens)
Pain Link Frequency Relevance Heat
methotrexate 11 100.00 Very High Very High Very High
cINOD 6 100.00 Very High Very High Very High
Paracetamol 3 98.32 Very High Very High Very High
Inflammation 1 93.24 High High
Potency 1 65.64 Quite High
diclofenac 3 52.60 Quite High
Bile 1 5.00 Very Low Very Low Very Low
lidocaine 1 5.00 Very Low Very Low Very Low
Versed 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 3 100.00 Very High Very High Very High
Disease 1 92.72 High High
Obesity 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interaction of nonsteroidal anti-inflammatory drugs with multidrug resistance protein (MRP) 2/ABCC2- and MRP4/ABCC4-mediated methotrexate transport.
ABCC2 Binding (Interaction) of associated with inflammation, cinod and methotrexate
1) Confidence 0.36 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 17005917 Disease Relevance 0.38 Pain Relevance 0.93
The activity of hCAR is regulated by a variety of xenobiotics including clotrimazole and acetaminophen metabolites. hCAR, in turn, regulates a number of genes responsible for xenobiotic metabolism and transport including several cytochrome P450s (CYP 2B5, 2C9, and 3A4) and the multidrug resistance-associated protein 2 (MRP2, ABCC2).
ABCC2 Binding (metabolism) of in 2B5 associated with paracetamol
2) Confidence 0.35 Published 2003 Journal Mol. Genet. Metab. Section Abstract Doc Link 14567971 Disease Relevance 0 Pain Relevance 0.10
The activity of hCAR is regulated by a variety of xenobiotics including clotrimazole and acetaminophen metabolites. hCAR, in turn, regulates a number of genes responsible for xenobiotic metabolism and transport including several cytochrome P450s (CYP 2B5, 2C9, and 3A4) and the multidrug resistance-associated protein 2 (MRP2, ABCC2).
MRP2 Binding (metabolism) of in 2B5 associated with paracetamol
3) Confidence 0.35 Published 2003 Journal Mol. Genet. Metab. Section Abstract Doc Link 14567971 Disease Relevance 0 Pain Relevance 0.10
The activity of hCAR is regulated by a variety of xenobiotics including clotrimazole and acetaminophen metabolites. hCAR, in turn, regulates a number of genes responsible for xenobiotic metabolism and transport including several cytochrome P450s (CYP 2B5, 2C9, and 3A4) and the multidrug resistance-associated protein 2 (MRP2, ABCC2).
resistance-associated protein 2 Binding (metabolism) of in 2B5 associated with paracetamol
4) Confidence 0.30 Published 2003 Journal Mol. Genet. Metab. Section Abstract Doc Link 14567971 Disease Relevance 0 Pain Relevance 0.10
However, there are no data regarding the contribution of rat Mdr1 to diazepam pharmacokinetics or of rat Mrp1 and human MRP2 in the case of grepafloxacin.
MRP2 Neg (no) Binding (contribution) of
5) Confidence 0.14 Published 2008 Journal Theor Biol Med Model Section Body Doc Link PMC2542356 Disease Relevance 0 Pain Relevance 0.03

General Comments

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