INT113866

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Context Info
Confidence 0.59
First Reported 2003
Last Reported 2007
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 1.67
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CXADR) extracellular region (CXADR) cell adhesion (CXADR)
mitochondrion organization (CXADR) plasma membrane (CXADR) nucleus (CXADR)
Anatomy Link Frequency
CAR 5
knob 1
2B5 1
CXADR (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 35 99.34 Very High Very High Very High
spinal dorsal horn 38 98.88 Very High Very High Very High
Paracetamol 5 97.76 Very High Very High Very High
gABA 8 88.24 High High
Central grey 3 73.32 Quite High
Pain 9 71.60 Quite High
hypoalgesia 3 62.84 Quite High
Kinase C 4 42.56 Quite Low
adenocard 5 38.56 Quite Low
cytokine 3 37.20 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 35 99.34 Very High Very High Very High
Infection 32 97.62 Very High Very High Very High
Nociception 20 92.16 High High
Generalized Anxiety Disorder 2 86.32 High High
Urological Neuroanatomy 3 73.32 Quite High
Pain 10 71.60 Quite High
Hypoalagesia 3 62.84 Quite High
Cancer 26 57.84 Quite High
Injury 5 52.96 Quite High
Colon Cancer 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Alternative splicing of CAR is obviously regulated in a tissue- and differentiation state-specific manner.
Regulation (regulated) of CAR in CAR
1) Confidence 0.59 Published 2004 Journal Nucl Recept Section Body Doc Link PMC406421 Disease Relevance 0 Pain Relevance 0
Compared to reference CAR(SV1), the intracellular distribution of the variants was not altered.
Neg (not) Regulation (altered) of CAR in CAR
2) Confidence 0.38 Published 2004 Journal Nucl Recept Section Body Doc Link PMC406421 Disease Relevance 0 Pain Relevance 0
In high-CAR containing A549 cells [43], infection of unmodified Ad5 was completely blocked by recombinant knob protein while heparin had little effect, confirming that unmodified Ad5 mainly infected cells through the CAR pathway (Fig. 5B).
Regulation (unmodified) of CAR in knob associated with infection
3) Confidence 0.28 Published 2007 Journal Virol J Section Body Doc Link PMC2134930 Disease Relevance 0.34 Pain Relevance 0
Thus alternative splicing of CAR further adds to the complex regulation of CAR expression and function.


Regulation (regulation) of CAR in CAR
4) Confidence 0.26 Published 2004 Journal Nucl Recept Section Body Doc Link PMC406421 Disease Relevance 0 Pain Relevance 0
This raises the intriguing question, whether transcription and splicing of CAR could be coordinately regulated.
Regulation (regulated) of CAR in CAR
5) Confidence 0.26 Published 2004 Journal Nucl Recept Section Body Doc Link PMC406421 Disease Relevance 0 Pain Relevance 0
The activity of hCAR is regulated by a variety of xenobiotics including clotrimazole and acetaminophen metabolites. hCAR, in turn, regulates a number of genes responsible for xenobiotic metabolism and transport including several cytochrome P450s (CYP 2B5, 2C9, and 3A4) and the multidrug resistance-associated protein 2 (MRP2, ABCC2).
Regulation (regulated) of hCAR in 2B5 associated with paracetamol
6) Confidence 0.13 Published 2003 Journal Mol. Genet. Metab. Section Abstract Doc Link 14567971 Disease Relevance 0 Pain Relevance 0.10
Without adult inflammation, seven genes showed significant CAR-P3-specific up-regulation in their expression in the LDH ipsilateral to the neonatally-injured hindpaw.
Regulation (regulation) of CAR in CAR associated with inflammation and spinal dorsal horn
7) Confidence 0.01 Published 2005 Journal Mol Pain Section Body Doc Link PMC1242251 Disease Relevance 1.33 Pain Relevance 0.57

General Comments

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