INT113887

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Context Info
Confidence 0.22
First Reported 2003
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 1.02
Pain Relevance 0.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell morphogenesis (P2rx7) mitochondrion organization (P2rx7) protein complex (P2rx7)
transmembrane transport (P2rx7) cytoplasm (P2rx7) cell death (P2rx7)
Anatomy Link Frequency
IB4 2
P2rx7 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 5 99.24 Very High Very High Very High
Neuropeptide 1 98.68 Very High Very High Very High
Spinal nerve ligature 2 96.36 Very High Very High Very High
sodium channel 1 90.28 High High
tetrodotoxin 1 89.28 High High
Neuropathic pain 3 83.48 Quite High
Thermal hyperalgesia 1 79.28 Quite High
intrathecal 1 78.92 Quite High
Root ganglion neuron 1 75.00 Quite High
Pain 3 25.00 Low Low
Disease Link Frequency Relevance Heat
Injury 2 99.72 Very High Very High Very High
Ganglion Cysts 6 99.24 Very High Very High Very High
Neuropathic Pain 3 83.48 Quite High
Hypersensitivity 1 80.96 Quite High
Hyperalgesia 1 79.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
They include a loss of binding of IB4, downregulation of the purinergic receptor P2X(3), upregulation of galanin and neuropeptide Y immunoreactivity in large diameter DRG cells, and expression of the transcription factor ATF3.
Positive_regulation (include) of Negative_regulation (downregulation) of purinergic receptor P2X in IB4 associated with dorsal root ganglion and neuropeptide
1) Confidence 0.22 Published 2003 Journal Neuroscience Section Abstract Doc Link 14568039 Disease Relevance 1.02 Pain Relevance 0.96

General Comments

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