INT113892

Context Info Confidence 0.48 First Reported 2003 Last Reported 2011 Negated 2 Speculated 0 Reported most in Body Documents 6 Total Number 7 Disease Relevance 3.95 Pain Relevance 2.65

cytosol (Cat) mitochondrion (Cat) oxidoreductase activity (Cat) Golgi apparatus (Cat) endoplasmic reticulum (Cat) plasma membrane (Cat)

Anatomy Link Frequency fibroblast 1 lung 1 Cat (Mus musculus)

Pain Link Frequency Relevance Heat isoflurane 9 98.90 Multiple sclerosis 13 98.64 qutenza 15 98.32 Inflammation 71 92.16 fibrosis 112 91.12 metalloproteinase 12 87.16 Neuritis 12 83.60 anesthesia 3 78.52 Central nervous system 4 60.96 imagery 2 58.72

Disease Link Frequency Relevance Heat Apoptosis 12 99.92 Fibrosis 88 99.84 Multiple Sclerosis 49 98.64 Acute Liver Failure 3 97.92 Injury 11 97.88 Lung Injury 9 92.84 INFLAMMATION 64 92.16 Pulmonary Fibrosis 58 88.56 Sprains And Strains 10 87.44 Critical Illness 2 84.72

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The interaction of these molecules with catalase has been reported in other cell types.

catalase Binding (interaction) of

1) Confidence 0.48 Published 2010 Journal Respir Res Section Body Doc Link PMC3022724 Disease Relevance 0.55 Pain Relevance 0.27

We also showed that ISO exerted its protection by significantly improving the activities of superoxide dismutase and catalase in lung and serum when compared with those in pentobarbital-treated mice.

catalase Binding (activities) of in lung associated with isoflurane

2) Confidence 0.35 Published 2010 Journal Shock Section Abstract Doc Link 20160672 Disease Relevance 0.99 Pain Relevance 0.53

Although the origin of fibroblast and fibroblastic foci remains to be clarified, they are not source of catalase in fibrotic lungs.

catalase Neg (not) Binding (source) of in fibroblast associated with fibrosis

3) Confidence 0.32 Published 2010 Journal Respir Res Section Body Doc Link PMC3022724 Disease Relevance 0.70 Pain Relevance 0.24

The antioxidant enzymes catalase and SOD can be used to target ROS for destruction, thus suppress tissue injury.

catalase Binding (used) of associated with injury

4) Confidence 0.32 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2504532 Disease Relevance 0.76 Pain Relevance 0.44

METHODS/RESULTS: Mangafodipir is endowed with superoxide dismutase, catalase, and glutathione reductase activities.

catalase Binding (endowed) of

5) Confidence 0.15 Published 2003 Journal J. Hepatol. Section Body Doc Link 14568259 Disease Relevance 0.10 Pain Relevance 0

Pretreatment with the antioxidant N-acetyl-L-cystein and catalase, but not superoxide dismutase, completely inhibited capsaicin-induced apoptosis by inhibiting phosphorylation of Ser-15 residue of p53.

catalase Neg (not) Binding (Pretreatment) of associated with qutenza and apoptosis

6) Confidence 0.06 Published 2004 Journal Cancer Res. Section Abstract Doc Link 14871840 Disease Relevance 0.65 Pain Relevance 1.11

This in turn leads to the formation of hydrogen peroxide that can be removed by catalase, conjugation with GSH (perhaps competing with GSH-mediated Cr(VI) reduction), as well as by Fenton reactions with iron.

catalase Binding (conjugation) of

7) Confidence 0.03 Published 2011 Journal Toxicological Sciences Section Body Doc Link PMC3003834 Disease Relevance 0.20 Pain Relevance 0.06

General Comments

This test has worked.