INT113892

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Context Info
Confidence 0.48
First Reported 2003
Last Reported 2011
Negated 2
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 3.95
Pain Relevance 2.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Cat) mitochondrion (Cat) oxidoreductase activity (Cat)
Golgi apparatus (Cat) endoplasmic reticulum (Cat) plasma membrane (Cat)
Anatomy Link Frequency
fibroblast 1
lung 1
Cat (Mus musculus)
Pain Link Frequency Relevance Heat
isoflurane 9 98.90 Very High Very High Very High
Multiple sclerosis 13 98.64 Very High Very High Very High
qutenza 15 98.32 Very High Very High Very High
Inflammation 71 92.16 High High
fibrosis 112 91.12 High High
metalloproteinase 12 87.16 High High
Neuritis 12 83.60 Quite High
anesthesia 3 78.52 Quite High
Central nervous system 4 60.96 Quite High
imagery 2 58.72 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 12 99.92 Very High Very High Very High
Fibrosis 88 99.84 Very High Very High Very High
Multiple Sclerosis 49 98.64 Very High Very High Very High
Acute Liver Failure 3 97.92 Very High Very High Very High
Injury 11 97.88 Very High Very High Very High
Lung Injury 9 92.84 High High
INFLAMMATION 64 92.16 High High
Pulmonary Fibrosis 58 88.56 High High
Sprains And Strains 10 87.44 High High
Critical Illness 2 84.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The interaction of these molecules with catalase has been reported in other cell types.
catalase Binding (interaction) of
1) Confidence 0.48 Published 2010 Journal Respir Res Section Body Doc Link PMC3022724 Disease Relevance 0.55 Pain Relevance 0.27
We also showed that ISO exerted its protection by significantly improving the activities of superoxide dismutase and catalase in lung and serum when compared with those in pentobarbital-treated mice.
catalase Binding (activities) of in lung associated with isoflurane
2) Confidence 0.35 Published 2010 Journal Shock Section Abstract Doc Link 20160672 Disease Relevance 0.99 Pain Relevance 0.53
Although the origin of fibroblast and fibroblastic foci remains to be clarified, they are not source of catalase in fibrotic lungs.
catalase Neg (not) Binding (source) of in fibroblast associated with fibrosis
3) Confidence 0.32 Published 2010 Journal Respir Res Section Body Doc Link PMC3022724 Disease Relevance 0.70 Pain Relevance 0.24
The antioxidant enzymes catalase and SOD can be used to target ROS for destruction, thus suppress tissue injury.
catalase Binding (used) of associated with injury
4) Confidence 0.32 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2504532 Disease Relevance 0.76 Pain Relevance 0.44
METHODS/RESULTS: Mangafodipir is endowed with superoxide dismutase, catalase, and glutathione reductase activities.
catalase Binding (endowed) of
5) Confidence 0.15 Published 2003 Journal J. Hepatol. Section Body Doc Link 14568259 Disease Relevance 0.10 Pain Relevance 0
Pretreatment with the antioxidant N-acetyl-L-cystein and catalase, but not superoxide dismutase, completely inhibited capsaicin-induced apoptosis by inhibiting phosphorylation of Ser-15 residue of p53.
catalase Neg (not) Binding (Pretreatment) of associated with qutenza and apoptosis
6) Confidence 0.06 Published 2004 Journal Cancer Res. Section Abstract Doc Link 14871840 Disease Relevance 0.65 Pain Relevance 1.11
This in turn leads to the formation of hydrogen peroxide that can be removed by catalase, conjugation with GSH (perhaps competing with GSH-mediated Cr(VI) reduction), as well as by Fenton reactions with iron.
catalase Binding (conjugation) of
7) Confidence 0.03 Published 2011 Journal Toxicological Sciences Section Body Doc Link PMC3003834 Disease Relevance 0.20 Pain Relevance 0.06

General Comments

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