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Context Info
Confidence 0.45
First Reported 2003
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 1.70

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plasma membrane (Mc4r) signal transducer activity (Mc4r)
Mc4r (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 15 99.48 Very High Very High Very High
tolerance 7 96.88 Very High Very High Very High
amygdala 5 96.68 Very High Very High Very High
withdrawal 1 91.92 High High
tail-flick 1 91.16 High High
antagonist 2 83.20 Quite High
Antinociceptive 1 70.56 Quite High
Opioid 2 69.04 Quite High


Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This decrease was attenuated following chronic morphine administration, and mRNA level of MC4 receptors was gradually increased and, on 9th day of morphine administration, i.e. in the period when morphine tolerance already developed, the level was significantly increased in comparison with control and with the effect after single morphine dose.
Positive_regulation (increased) of Transcription (level) of MC4 associated with tolerance and morphine
1) Confidence 0.45 Published 2003 Journal Brain Res. Section Abstract Doc Link 14568335 Disease Relevance 0 Pain Relevance 1.70

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