INT11390

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.65
First Reported 1987
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 3.09
Pain Relevance 2.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (PF4) extracellular region (PF4)
Anatomy Link Frequency
granulocyte 2
platelet 2
blood 1
plasma 1
PF4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Migraine 5 98.14 Very High Very High Very High
cva 4 97.36 Very High Very High Very High
chemokine 118 91.60 High High
Inflammation 100 84.88 Quite High
adenocard 1 80.44 Quite High
Pain 4 80.24 Quite High
Angina 1 77.56 Quite High
Restless leg syndrome 1 35.20 Quite Low
rheumatoid arthritis 68 27.44 Quite Low
Arthritis 58 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hemorrhage 2 99.56 Very High Very High Very High
Headache 5 98.14 Very High Very High Very High
Fat Embolism 1 97.36 Very High Very High Very High
Adhesions 65 95.80 Very High Very High Very High
Reprotox - General 2 6 89.00 High High
Thrombosis 3 88.08 High High
INFLAMMATION 100 84.88 Quite High
Angina 1 77.56 Quite High
Respiratory Distress 1 76.96 Quite High
Leukemia 3 76.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
HIT II was diagnosed clinically; heparin-induced platelet activation test (HIPA) and serum IgG, IgA, and IgM to heparin-platelet factor 4 complexes (HPF4) were both negative.
Neg (negative) Gene_expression (negative) of platelet factor 4 in platelet
1) Confidence 0.65 Published 2000 Journal Pediatr. Nephrol. Section Abstract Doc Link 10955913 Disease Relevance 0.38 Pain Relevance 0.08
Several studies have shown that migraine is associated with an abnormal platelet activation state, characterized by increased plasma levels of platelet BTG and PF4 proteins.
Gene_expression (levels) of PF4 in plasma associated with migraine
2) Confidence 0.58 Published 1991 Journal Neurologia Section Abstract Doc Link 1931099 Disease Relevance 0.31 Pain Relevance 0.51
In this patient, platelet function was estimated in vivo by the levels of antiheparin platelet factor 4 and beta-thromboglobulin.
Gene_expression (levels) of antiheparin platelet factor 4 in platelet
3) Confidence 0.43 Published 1992 Journal JPEN J Parenter Enteral Nutr Section Abstract Doc Link 1556816 Disease Relevance 1.07 Pain Relevance 0.11
/CXCL1, connective tissue-activating peptide-III (CTAP-III)/CXCL7, granulocyte chemotactic protein-2/CXCL6, IP-10/CXCL10, PF4/CXCL4, monokine induced by IFN-?
Gene_expression (/) of PF4 in granulocyte
4) Confidence 0.40 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592799 Disease Relevance 0.38 Pain Relevance 0.65
/CXCL1, connective tissue-activating peptide-III (CTAP-III)/CXCL7, granulocyte chemotactic protein-2/CXCL6, IP-10/CXCL10, PF4/CXCL4, monokine induced by IFN-?
Gene_expression (/) of CXCL4 in granulocyte
5) Confidence 0.40 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592799 Disease Relevance 0.38 Pain Relevance 0.65
Ticlopidine also inhibits the release reaction of platelets, prolongs bleeding time, reduces plasma levels of platelet factor 4 and beta-thromboglobulin in patients in whom these proteins are elevated, and may also inhibit platelet adhesion, increase red cell filtrability and decrease whole blood viscosity.
Gene_expression (levels) of platelet factor 4 in blood associated with hemorrhage and adhesions
6) Confidence 0.35 Published 1987 Journal Drugs Section Abstract Doc Link 3304967 Disease Relevance 0.59 Pain Relevance 0.07

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox