INT113906

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Context Info
Confidence 0.27
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.20
Pain Relevance 2.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CCL2) extracellular space (CCL2) aging (CCL2)
extracellular region (CCL2) cell adhesion (CCL2) cytoskeleton organization (CCL2)
Anatomy Link Frequency
plasma 2
CCL2 (Homo sapiens)
Pain Link Frequency Relevance Heat
lidocaine 6 99.90 Very High Very High Very High
Inflammation 63 99.84 Very High Very High Very High
Fibrositis 97 99.16 Very High Very High Very High
Paracetamol 3 98.98 Very High Very High Very High
cytokine 236 98.36 Very High Very High Very High
chemokine 24 97.80 Very High Very High Very High
Chronic pancreatitis 33 91.84 High High
Pain 11 85.08 High High
antagonist 2 75.12 Quite High
Inflammatory stimuli 1 51.84 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 68 99.84 Very High Very High Very High
Fibromyalgia 97 99.16 Very High Very High Very High
Overdose 2 99.16 Very High Very High Very High
Primary Sclerosing Cholangitis 77 97.28 Very High Very High Very High
Sepsis 15 93.20 High High
Pancreatitis 33 91.84 High High
Vasculitis 2 90.36 High High
Fatigue 2 89.36 High High
Neurosyphilis 1 88.52 High High
Pain 10 85.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that lidocaine may modulate MCP-1 production and MCP-1-induced activation in inflammatory cells.
Regulation (modulate) of Positive_regulation (activation) of MCP-1-induced associated with inflammation and lidocaine
1) Confidence 0.27 Published 2003 Journal Anesth. Analg. Section Abstract Doc Link 14570645 Disease Relevance 0.42 Pain Relevance 0.74
The lack of the usual wide variation in plasma MCP-1 and IP-10 levels in FMS patients with the common R202Q allele may indicate that this variant has a functional connection to the production of these two cytokines, rather than IL-1?
Regulation (lack) of Positive_regulation (variation) of MCP-1 in plasma associated with fibrositis and cytokine
2) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794536 Disease Relevance 0.77 Pain Relevance 0.44
There is also an inverse regulation of IL-6 and MCP-1 mRNA induction by PBMC derived from different sources: while the increase in IL-6 expression on the mRNA level was only seen in PBMC from healthy donors, MCP-1 was significantly induced in cocultured PBMC from donors, CP and septic shock patients.
Regulation (regulation) of Positive_regulation (induction) of MCP-1 associated with chronic pancreatitis and sepsis
3) Confidence 0.15 Published 2007 Journal J Transl Med Section Body Doc Link PMC2234395 Disease Relevance 1.60 Pain Relevance 0.49
A study of acetaminophen overdose in a clinical population demonstrated an increase in IL8, IL6, and MCP-1 in the most severely affected patients (based on serum ALT), yet only MCP-1 had a good correlation (R2 = 0.607) over the range of severity (James et al., 2005).
Regulation (affected) of Positive_regulation (increase) of MCP-1 associated with paracetamol and overdose
4) Confidence 0.03 Published 2010 Journal Toxicological Sciences Section Body Doc Link PMC2923281 Disease Relevance 0.41 Pain Relevance 0.49

General Comments

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