INT113907

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Context Info
Confidence 0.62
First Reported 2003
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 2.46
Pain Relevance 2.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CCL2) extracellular space (CCL2) aging (CCL2)
extracellular region (CCL2) cell adhesion (CCL2) cytoskeleton organization (CCL2)
Anatomy Link Frequency
monocyte 2
THP-1 2
CCL2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 58 100.00 Very High Very High Very High
lidocaine 6 100.00 Very High Very High Very High
Inflammation 97 98.28 Very High Very High Very High
dexamethasone 43 97.44 Very High Very High Very High
antagonist 42 94.48 High High
Cannabinoid 26 61.96 Quite High
Cannabinoid receptor 18 57.00 Quite High
agonist 24 53.00 Quite High
Endocannabinoid 24 50.16 Quite High
fibrosis 12 50.00 Quite Low
Disease Link Frequency Relevance Heat
Primary Sclerosing Cholangitis 44 100.00 Very High Very High Very High
INFLAMMATION 101 98.28 Very High Very High Very High
Apoptosis 18 96.96 Very High Very High Very High
Sepsis 1 96.40 Very High Very High Very High
Adhesions 10 95.68 Very High Very High Very High
Atherosclerotic Plaque 1 93.12 High High
Death 4 89.60 High High
Necrosis 6 81.28 Quite High
Increased Venous Pressure Under Development 63 74.16 Quite High
Myocardial Infarction 28 70.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, we examined the effect of lidocaine on lipopolysaccharide-stimulated MCP-1 secretion and MCP-1 induced chemotaxis in a human monocytic cell line, THP-1.
Spec (examined) Regulation (effect) of Localization (secretion) of MCP-1 in THP-1 associated with lidocaine
1) Confidence 0.62 Published 2003 Journal Anesth. Analg. Section Abstract Doc Link 14570645 Disease Relevance 0.39 Pain Relevance 0.67
resp.) while fetal MCP-1 concentrations were significantly lower
Regulation (fetal) of Localization (concentrations) of MCP-1
2) Confidence 0.39 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2234089 Disease Relevance 0.06 Pain Relevance 0.06
resp.) while fetal MCP-1 concentrations were significantly lower
Regulation (fetal) of Localization (concentrations) of MCP-1
3) Confidence 0.39 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2234089 Disease Relevance 0.08 Pain Relevance 0.14
To assess the effects of WIN treatment of PSC on the secretion of cytokines IL-6, MCP-1 and TGFbeta, cell culture supernatants were subjected to ELISA.
Regulation (effects) of Localization (secretion) of MCP-1 associated with primary sclerosing cholangitis and cytokine
4) Confidence 0.18 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2253501 Disease Relevance 0.63 Pain Relevance 0.34
ATP stimulates release of IL-6, IL-8, monocyte chemoattractant protein-1, growth-regulated oncogene ?
Regulation (regulated) of Localization (release) of monocyte chemoattractant protein-1 in monocyte
5) Confidence 0.14 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245998 Disease Relevance 1.09 Pain Relevance 0.15
Both BOL-303242-X and DEX inhibited LPS-induced IL-6, IL-12p40, and MCP-1 release in a dose-dependent manner, and a statistically significant inhibitory effect on IL-6, IL-12p40, and MCP-1 release was observed at 1 nM (Figure 5).
Regulation (effect) of Localization (release) of MCP-1 associated with dexamethasone
6) Confidence 0.13 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2790480 Disease Relevance 0.21 Pain Relevance 0.69

General Comments

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