INT113908

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Context Info
Confidence 0.57
First Reported 2002
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 4.35
Pain Relevance 1.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (TNFRSF10B)
Anatomy Link Frequency
blood 1
astrocytes 1
lung 1
TNFRSF10B (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 14 99.82 Very High Very High Very High
anesthesia 2 98.00 Very High Very High Very High
ketamine 4 90.96 High High
agonist 28 89.00 High High
halothane 3 83.20 Quite High
Pain 2 81.28 Quite High
antagonist 24 81.04 Quite High
Perioperative pain 1 68.00 Quite High
Inflammation 3 66.16 Quite High
analgesia 1 59.44 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 186 99.54 Very High Very High Very High
Lung Cancer 11 98.72 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

1 98.20 Very High Very High Very High
Metastasis 11 97.56 Very High Very High Very High
Glioma 8 94.80 High High
Hypothermia 1 94.16 High High
Renal Cancer 2 90.32 High High
Cancer 91 90.20 High High
Adenocarcinoma 1 81.88 Quite High
Reprotox - General 1 6 81.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
All anesthetics, except propofol, significantly reduced NK activity and increased MADB106 lung tumor retention or lung metastases.
Negative_regulation (reduced) of NK in lung associated with lung cancer and metastasis
1) Confidence 0.57 Published 2003 Journal Anesth. Analg. Section Abstract Doc Link 14570648 Disease Relevance 1.07 Pain Relevance 0.44
Surgery increased interleukin-6 levels and suppressed NK activity per milliliter blood.
Negative_regulation (suppressed) of NK in blood
2) Confidence 0.57 Published 2002 Journal J Pain Section Abstract Doc Link 14622754 Disease Relevance 0.90 Pain Relevance 0.41
apoptosis by 15d-PGJ2 since the knockdown of DR5 using DR5 siRNA
Negative_regulation (knockdown) of DR5 associated with apoptosis
3) Confidence 0.21 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442903 Disease Relevance 0.90 Pain Relevance 0.08
These results indicate that mitochondrial-mediated apoptosis in HepG2 cells, triggered by DLS, is predominantly associated with down-regulation of the Bcl-2/Bax expression ratio.Fig. 3Western blot analysis of the expression levels of caspase3, caspase9, Bcl-2, Bax, caspase8 and DR5 with the treatment of DLS for 24 h (All the experiments were repeated four times.)Fig. 4Bcl-2, Bax, DR5 protein expression in HepG2 cells (×200). a, c, e Immunocytochemistry of Bcl-2, Bax and DR5 staining in HepG2 cells for 24 h of treatment without DLS. b, d, f Immunocytochemistry of Bcl-2, Bax and DR5 staining in HepG2 cells for 24 h of treatment with 25 ?
Negative_regulation (regulation) of DR5 associated with apoptosis
4) Confidence 0.18 Published 2009 Journal Mol Biol Rep Section Body Doc Link PMC2941086 Disease Relevance 0.64 Pain Relevance 0
Neither capsaicin-induced DR5 upregulation/survivin downregulation nor the partial processing of procaspase-3 by TRAIL was induced in astrocytes.
Neg (nor) Negative_regulation (downregulation) of DR5 in astrocytes associated with qutenza
5) Confidence 0.11 Published 2010 Journal Carcinogenesis Section Abstract Doc Link 19939880 Disease Relevance 0.75 Pain Relevance 0.78

General Comments

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