INT113913

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Context Info
Confidence 0.27
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 23
Total Number 32
Disease Relevance 1.57
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Hephl1) oxidoreductase activity (Hephl1) cellular_component (Hephl1)
biological_process (Hephl1)
Anatomy Link Frequency
spermatozoa 21
oocytes 6
plasma 1
uterine 1
female reproductive tract 1
Hephl1 (Mus musculus)
Pain Link Frequency Relevance Heat
Bile 3 99.84 Very High Very High Very High
cINOD 1 54.24 Quite High
ketamine 30 5.00 Very Low Very Low Very Low
butorphanol 20 5.00 Very Low Very Low Very Low
anesthesia 10 5.00 Very Low Very Low Very Low
Inflammation 10 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
medulla 2 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
pain pelvic 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disseminated Intravascular Coagulation 4 98.68 Very High Very High Very High
Chromosome Aberrations 21 96.52 Very High Very High Very High
Congenital Anomalies 31 96.48 Very High Very High Very High
Heat Stress Disorders 210 93.68 High High
Adhesions 12 85.40 High High
Sperm Disorder 70 74.88 Quite High
Toxicity 1 60.76 Quite High
INFLAMMATION 11 54.04 Quite High
Apoptosis 21 28.88 Quite Low
Tumor Necrosis Factor Receptor-associated Periodic Syndrome 30 16.96 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is not likely that the cleansing procedures, in particular using Percoll gradients, would have influenced the results of the ZBA, considering the very few FT spermatozoa that bound to in vitro matured ZP in comparison with freshly ejaculated spermatozoa.
ZP Binding (bound) of in spermatozoa
1) Confidence 0.27 Published 2007 Journal Acta Vet Scand Section Body Doc Link PMC2092430 Disease Relevance 0 Pain Relevance 0
However, the lack of binding to FT ZP is mainly due to the ZP and not to the spermatozoa, since fresh spermatozoa also had markedly decreased binding to FT ZP.
ZP Binding (binding) of in spermatozoa
2) Confidence 0.27 Published 2007 Journal Acta Vet Scand Section Body Doc Link PMC2092430 Disease Relevance 0 Pain Relevance 0
The hypothesis that cat spermatozoa, either fresh or FT, could bind to homologous ZP of oocytes retrieved from FT queen ovaries to a similar extent as to the ZP of fresh, in vitro matured oocytes, proved false.
ZP Binding (bind) of in oocytes
3) Confidence 0.27 Published 2007 Journal Acta Vet Scand Section Body Doc Link PMC2092430 Disease Relevance 0 Pain Relevance 0
Such differences in viability between fresh and FT spermatozoa may explain the differences in ZP binding registered.
ZP Binding (binding) of in spermatozoa
4) Confidence 0.27 Published 2007 Journal Acta Vet Scand Section Body Doc Link PMC2092430 Disease Relevance 0 Pain Relevance 0
The spermatozoa bound to the ZP were counted with epifluorescence ultraviolet (UV) illumination on a Leitz Dialux 20 microscope (× 400) (Wetzlar, Germany).


ZP Binding (bound) of in spermatozoa
5) Confidence 0.21 Published 2007 Journal Acta Vet Scand Section Body Doc Link PMC2092430 Disease Relevance 0 Pain Relevance 0
The random effect of replicate, nested within the combination between ZP and spermatozoa, was also included in the statistical model.
ZP Binding (combination) of in spermatozoa
6) Confidence 0.21 Published 2007 Journal Acta Vet Scand Section Body Doc Link PMC2092430 Disease Relevance 0 Pain Relevance 0
However, the authors regarded the results as positive if at least one sperm bound to the ZP.
ZP Binding (bound) of in sperm
7) Confidence 0.20 Published 2007 Journal Acta Vet Scand Section Body Doc Link PMC2092430 Disease Relevance 0 Pain Relevance 0
The present study tested the hypothesis that cat spermatozoa, either fresh or FT, can bind to homologous ZP of oocytes retrieved from FT queen ovaries to a similar extent as they can bind to the ZP of fresh, in vitro matured oocytes.


ZP Binding (bind) of in spermatozoa
8) Confidence 0.20 Published 2007 Journal Acta Vet Scand Section Body Doc Link PMC2092430 Disease Relevance 0 Pain Relevance 0
Abnormal cat spermatozoa are capable of binding to and entering the outer ZP but are usually compromised in their ability to penetrate the inner zona and reach the perivitelline space to fertilise the oocyte [14,15].
ZP Binding (binding) of in oocyte
9) Confidence 0.20 Published 2007 Journal Acta Vet Scand Section Body Doc Link PMC2092430 Disease Relevance 0.10 Pain Relevance 0
Both fresh and FT spermatozoa bound to the ZP of in vitro matured oocytes (Table 1, Figure 1).
ZP Binding (bound) of in oocytes
10) Confidence 0.20 Published 2007 Journal Acta Vet Scand Section Body Doc Link PMC2092430 Disease Relevance 0 Pain Relevance 0
Overall, binding was significantly different between in vitro matured and immature, FT ZP (P < 0.05).
ZP Binding (binding) of
11) Confidence 0.20 Published 2007 Journal Acta Vet Scand Section Body Doc Link PMC2092430 Disease Relevance 0 Pain Relevance 0
The statistical models included the fixed effects of ZP status (in vitro matured or FT) and spermatozoa status (fresh or FT) and the interactions between ZP and spermatozoa status.
ZP Binding (interactions) of in spermatozoa
12) Confidence 0.20 Published 2007 Journal Acta Vet Scand Section Body Doc Link PMC2092430 Disease Relevance 0 Pain Relevance 0
The present study tested the hypothesis that cat spermatozoa, either fresh or FT, can bind to homologous ZP of oocytes retrieved from FT queen ovaries to a similar extent as they can bind to the ZP of fresh, in vitro matured oocytes.


ZP Binding (bind) of in spermatozoa
13) Confidence 0.20 Published 2007 Journal Acta Vet Scand Section Body Doc Link PMC2092430 Disease Relevance 0 Pain Relevance 0
Only a very low number of fresh spermatozoa bound to FT ZP, compared with their fresh, in vitro matured counterparts.
ZP Binding (bound) of in spermatozoa
14) Confidence 0.20 Published 2007 Journal Acta Vet Scand Section Body Doc Link PMC2092430 Disease Relevance 0 Pain Relevance 0
The functional ability of the ZP to bind spermatozoa is closely related to its morphological appearance [38].
ZP Binding (bind) of in spermatozoa
15) Confidence 0.20 Published 2007 Journal Acta Vet Scand Section Body Doc Link PMC2092430 Disease Relevance 0 Pain Relevance 0
Also, comparatively more fresh, electroejaculated than FT spermatozoa bound to the ZP (P < 0.001), with barely one fresh spermatozoon bound per FT ZP.
ZP Binding (bound) of in spermatozoon
16) Confidence 0.20 Published 2007 Journal Acta Vet Scand Section Body Doc Link PMC2092430 Disease Relevance 0 Pain Relevance 0
In the study in cats, FT, immature oocytes were used in a ZBA with FT epididymal spermatozoa, and 16 out of 20 of the sperm samples bound to the ZP.
ZP Binding (bound) of in oocytes
17) Confidence 0.20 Published 2007 Journal Acta Vet Scand Section Body Doc Link PMC2092430 Disease Relevance 0 Pain Relevance 0
Our results clearly show a decreased, but not abolished, capacity of FT spermatozoa to bind to in vitro matured ZP.
ZP Binding (bind) of in spermatozoa
18) Confidence 0.20 Published 2007 Journal Acta Vet Scand Section Body Doc Link PMC2092430 Disease Relevance 0 Pain Relevance 0
The number of spermatozoa bound to each ZP was not reported.
ZP Binding (bound) of in spermatozoa
19) Confidence 0.20 Published 2007 Journal Acta Vet Scand Section Body Doc Link PMC2092430 Disease Relevance 0 Pain Relevance 0
This may partly be due to changes in the capacity of spermatozoa to maintain a normal plasma membrane surface that could bind to the specific receptors present in the ZP.
ZP Binding (bind) of in plasma
20) Confidence 0.20 Published 2007 Journal Acta Vet Scand Section Body Doc Link PMC2092430 Disease Relevance 0 Pain Relevance 0

General Comments

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