INT113924

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Context Info
Confidence 0.38
First Reported 2001
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 27
Total Number 27
Disease Relevance 8.64
Pain Relevance 3.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Mapk1) mitochondrion (Mapk1) protein complex (Mapk1)
cytoplasm (Mapk1) cytosol (Mapk1) signal transduction (Mapk1)
Anatomy Link Frequency
liver 1
nucleus 1
adult mouse 1
Mapk1 (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 7 99.56 Very High Very High Very High
addiction 4 99.28 Very High Very High Very High
substance P 4 99.14 Very High Very High Very High
Morphine 9 99.06 Very High Very High Very High
Glutamate 5 98.64 Very High Very High Very High
narcan 5 97.24 Very High Very High Very High
c fibre 4 95.68 Very High Very High Very High
rheumatoid arthritis 65 95.36 Very High Very High Very High
Dorsal horn neuron 2 92.32 High High
cOX1 10 92.24 High High
Disease Link Frequency Relevance Heat
Cancer 704 99.76 Very High Very High Very High
Morphine Dependence 2 99.28 Very High Very High Very High
Congenital Anomalies 8 99.02 Very High Very High Very High
Injury 68 98.70 Very High Very High Very High
Death 77 97.40 Very High Very High Very High
Infection 26 95.96 Very High Very High Very High
Apoptosis 131 95.36 Very High Very High Very High
Virus Diseases 94 95.36 Very High Very High Very High
Rheumatoid Arthritis 65 95.36 Very High Very High Very High
INFLAMMATION 290 91.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
above description, interaction with the ERK cascade plays an important role in
ERK cascade Binding (interaction) of
1) Confidence 0.38 Published 2008 Journal PPAR Research Section Body Doc Link PMC2440494 Disease Relevance 0 Pain Relevance 0
A neuroactive steroid, dehydroepiandrosterone sulfate, prevents the development of morphine dependence and tolerance via c-fos expression linked to the extracellular signal-regulated protein kinase.
extracellular signal-regulated protein kinase Binding (linked) of associated with addiction, narcan, tolerance and morphine
2) Confidence 0.36 Published 2004 Journal Behav. Brain Res. Section Title Doc Link 15196791 Disease Relevance 0.41 Pain Relevance 1.58
BDNF signaling via TrkB receptors but not SP signaling via NK(1) were also involved in ERK recruitment.
ERK Binding (recruitment) of associated with substance p
3) Confidence 0.33 Published 2003 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 14572451 Disease Relevance 0 Pain Relevance 0.89
INTERACTION WITH THE ERK CASCADE AS A DRUG TARGET
ERK CASCADE Binding (INTERACTION) of
4) Confidence 0.33 Published 2008 Journal PPAR Research Section Body Doc Link PMC2440494 Disease Relevance 0.68 Pain Relevance 0
g Rat Agtr1a (AT1R), Rat Mapk3 (ERK1), and Rat Mapk1 (ERK2) or control shRNA was incubated with 10 ?
ERK2 Binding (incubated) of
5) Confidence 0.32 Published 2008 Journal Diabetes Section Body Doc Link PMC2494692 Disease Relevance 0.07 Pain Relevance 0.07
g Rat Agtr1a (AT1R), Rat Mapk3 (ERK1), and Rat Mapk1 (ERK2) or control shRNA was incubated with 10 ?
Mapk1 Binding (incubated) of
6) Confidence 0.32 Published 2008 Journal Diabetes Section Body Doc Link PMC2494692 Disease Relevance 0.07 Pain Relevance 0.07
Western blot for ERK
ERK Binding (blot) of
7) Confidence 0.31 Published 2010 Journal Crit Care Section Body Doc Link PMC2887192 Disease Relevance 0.07 Pain Relevance 0
through their ability to trigger ERK cascade activation [70].
ERK cascade Binding (trigger) of
8) Confidence 0.29 Published 2008 Journal PPAR Research Section Body Doc Link PMC2440494 Disease Relevance 0.65 Pain Relevance 0.12
signaling pathways, crosstalk with the ERK cascade and elevated PPAR?
ERK cascade Binding (crosstalk) of
9) Confidence 0.29 Published 2008 Journal PPAR Research Section Body Doc Link PMC2440494 Disease Relevance 0.88 Pain Relevance 0
receptor and the ERK cascade in the
ERK cascade Binding (receptor) of
10) Confidence 0.29 Published 2008 Journal PPAR Research Section Body Doc Link PMC2440494 Disease Relevance 0.52 Pain Relevance 0
Sections were incubated with monoclonal rabbit anti-phospho-Thr202/Tyr204 ERK (1:500) overnight and antibody binding was detected using Vectastain Elite ABC Kit (Vector Laboratories, Burlingame, CA, USA).
ERK Binding (binding) of
11) Confidence 0.26 Published 2010 Journal Crit Care Section Body Doc Link PMC2887192 Disease Relevance 0 Pain Relevance 0.04
Nevertheless, although the effects of follistatin hyperexpression are phenotypically comparable to those exerted by ERK inhibition, the mechanisms involved are quite different.
ERK Binding (inhibition) of
12) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965098 Disease Relevance 0.25 Pain Relevance 0
During differentiation, phosphorylated ERK, occurring at high levels over days 1–3, progressively declines concomitantly with Pax7 reduction and myogenin and MyoD increases (Fig.
ERK Binding (declines) of
13) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965098 Disease Relevance 0.28 Pain Relevance 0
Interestingly, the induction of immediate early genes c-Fos and Egr-1 which can function as sensors for duration of Erk1/2 signaling [20] was reduced in c-Met mutant mice, particularly at the later time points of liver regeneration (Figure S3).
Erk1/2 Binding (duration) of in liver
14) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2940888 Disease Relevance 0.06 Pain Relevance 0
Furthermore, a direct association between ERK and a DED-containing fragment of caspase-8, and co-transport of an ERK-caspase-8-DED complex to the nucleus during apoptosis has been reported [36].
ERK Binding (association) of in nucleus associated with apoptosis
15) Confidence 0.11 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2978204 Disease Relevance 0.98 Pain Relevance 0
Abnormalities in signaling pathways of MAPK, particularly the ERK pathway, are associated with cancers in mice and humans (reviewed in [108]).
ERK Binding (associated) of associated with cancer and congenital anomalies
16) Confidence 0.10 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.99 Pain Relevance 0.24
transformation by delphinidin involves the blockage of ERK and
ERK Binding (blockage) of
17) Confidence 0.09 Published 2004 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1082887 Disease Relevance 0.11 Pain Relevance 0
Analysis of the bound proteins by SDS-PAGE followed by silver staining and Western blotting showed that (S)-roscovitine preferentially bound Erk2 and CDK5 in the adult mouse brain (Figure 3B).
Erk2 Binding (bound) of in adult mouse
18) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920814 Disease Relevance 0.26 Pain Relevance 0.04
Here, we showed that the stimulation with glycine did not interfere with ERK 1/2 activation, suggesting that some pathways leading to ERK 1/2 activation are preserved following infection with BDV.
ERK Neg (not) Binding (interfere) of associated with virus diseases and infection
19) Confidence 0.08 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1401496 Disease Relevance 0.60 Pain Relevance 0.32
signaling to ERK
ERK Binding (signaling) of
20) Confidence 0.06 Published 2008 Journal Molecular and Cellular Endocrinology Section Body Doc Link PMC2694994 Disease Relevance 0 Pain Relevance 0.16

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