INT113925

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Context Info
Confidence 0.79
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 59
Total Number 59
Disease Relevance 24.03
Pain Relevance 22.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Bdnf) cytoplasmic membrane-bounded vesicle (Bdnf)
Anatomy Link Frequency
microglia 5
brain 3
dorsal horn 3
retina 2
hippocampus 2
Bdnf (Mus musculus)
Pain Link Frequency Relevance Heat
bDMF 200 100.00 Very High Very High Very High
Glutamate 135 100.00 Very High Very High Very High
cytokine 56 100.00 Very High Very High Very High
chemokine 34 100.00 Very High Very High Very High
substance P 30 100.00 Very High Very High Very High
Neuropeptide 12 100.00 Very High Very High Very High
Central nervous system 115 99.92 Very High Very High Very High
antidepressant 883 99.88 Very High Very High Very High
Hyperalgesia 19 99.88 Very High Very High Very High
Dorsal horn 79 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 45 100.00 Very High Very High Very High
Hyperalgesia 30 99.88 Very High Very High Very High
Neuropathic Pain 76 99.80 Very High Very High Very High
Nervous System Injury 76 99.80 Very High Very High Very High
Nociception 92 99.36 Very High Very High Very High
Urological Neuroanatomy 208 99.28 Very High Very High Very High
Inflammatory Pain 5 99.12 Very High Very High Very High
Depression 1236 99.00 Very High Very High Very High
Injury 160 98.96 Very High Very High Very High
Pain 458 98.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further localization of TrkB occurs at the synaptic sites after neuroanal activity.55 Neuronal activity, therefore, is critical for synthesis and intracellular targeting of TrkB receptors.55 Thus, BDNF release and expression of TrkB receptors in a coordinated fashion are important for optimal synaptic response.
Localization (release) of BDNF in Neuronal
1) Confidence 0.79 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.41 Pain Relevance 0.18
For example, what role does dendritic localization of BDNF/TrkB play in altered plasticity in these disorders?
Localization (localization) of BDNF
2) Confidence 0.79 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 1.74 Pain Relevance 0.14
The gene encoding human BDNF is localized at chromosome 11p13.
Localization (localized) of BDNF
3) Confidence 0.79 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.32 Pain Relevance 0.49
As mentioned earlier, this Met66 variant affects activity-dependent BDNF secretion.56,59 This is critical for dendritic trafficking and synaptic localization of BDNF.
Localization (localization) of BDNF
4) Confidence 0.79 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.59 Pain Relevance 0.44
In spinal cord dorsal horn, activated microglia can release some chemokines like NGF, BDNF, IL-1?
Localization (release) of BDNF in microglia associated with chemokine, dorsal horn and spinal cord
5) Confidence 0.72 Published 2010 Journal Mol Pain Section Body Doc Link PMC2857828 Disease Relevance 0.12 Pain Relevance 0.43
A common single nucleotide polymorphism (SNP) consisting of a missense change (G196A), which produces a non-conservative amino acid change (valine to methionine), has been identified in the coding exon of the BDNF gene at position 66 (Val66Met, rs6265).15 The replacement of 66Val by 66Met disrupts cellular processing, trafficking, and activity-dependent secretion of BDNF.16 Our first studies on the genetic association between the BDNF Val66Met polymorphism and MDD in outpatients17 as well as inpatients18 were in 2003.
Localization (secretion) of BDNF associated with depression
6) Confidence 0.70 Published 2010 Journal Psychiatry Investigation Section Body Doc Link PMC3022309 Disease Relevance 0.61 Pain Relevance 0.22
Lastly, it should be remembered that microglial activation and BDNF release in dorsal horn following injury is transient [66-72], whereas the maintenance of chronic neuropathic pain appears to involve alterations in astrocyte functions [16,17,36-40].
Localization (release) of BDNF in astrocyte associated with injury, neuropathic pain, dorsal horn and bdmf
7) Confidence 0.70 Published 2010 Journal Mol Pain Section Body Doc Link PMC2918544 Disease Relevance 0.68 Pain Relevance 0.77
To visualize the colocalization of BDNF with NeuN or GFAP, we performed double immunofluorescence on the SC sections from the NMDA-treated mice.
Localization (colocalization) of BDNF
8) Confidence 0.70 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2664844 Disease Relevance 0 Pain Relevance 0
BDNF injected into the retina may be internalized by retinal ganglion neurons and transported to the SC, where BDNF may be released and transferred to the postsynaptic neurons [52].
Localization (released) of BDNF in retina associated with ganglion cysts
9) Confidence 0.69 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2664844 Disease Relevance 0.32 Pain Relevance 0.03
However, when BDNF level was determined in platelets, it was found that platelet BDNF levels were lower in both nonsuicidal and suicidal depressed patients compared with healthy controls, whereas no significant differences were noted between nonsuicidal and suicidal depressed patients.188 Interestingly, Dawood et al189 used direct internal jugular vein blood sampling methods to circumvent the issue of whether BDNF is released from other sources than the brain and they examined the relationship between brain BDNF production and suicide risk in untreated patients with depression.
Localization (released) of BDNF in blood associated with suicidal behaviour and depression
10) Confidence 0.69 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.95 Pain Relevance 0.13
Interestingly, knockout mice carrying the Val66Met polymorphism show reduced activity-dependent secretion of BDNF, without any change in the level of total BDNF.152 More interestingly, mice carrying the BDNF Met/Met or Val/Met allele show a reduced volume of hippocampus compared with wild-type mice, and BDNF Met/Met knock-in mice have reduced dendritic arbor complexity.152 These studies are quite relevant to depression, because structural abnormalities, particularly structural abnormalities in the brain, including reduced hippocampal volume during stress and in depressed patients, have been reported,153,154 which increases the risk for depression.
Localization (secretion) of BDNF in brain associated with stress, targeted disruption, depression, congenital anomalies and hippocampus
11) Confidence 0.69 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.77 Pain Relevance 0.40
Taken together, these findings suggest that the binding of spinally released BDNF to TrkB by nerve ligation may activate PKC within the spinal cord, resulting in the development of a neuropathic pain-like state in mice.
Localization (released) of BDNF in spinal cord associated with kinase c, neuropathic pain and spinal cord
12) Confidence 0.68 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15836617 Disease Relevance 0.62 Pain Relevance 0.84
In this study, we didn't find any enhanced motility of microglia after local application of MCP-1, FKN, BDNF, NGF, IL-1?
Localization (application) of BDNF in microglia
13) Confidence 0.67 Published 2010 Journal Mol Pain Section Body Doc Link PMC2857828 Disease Relevance 0.18 Pain Relevance 0.61
Furthermore, ATP stimulation is unable to stimulate BDNF release from P2X(4)-deficient mice microglia in primary cultures.
Localization (release) of BDNF in microglia
14) Confidence 0.65 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18971468 Disease Relevance 0.81 Pain Relevance 0.87
BDNF injected into the retina may be internalized by retinal ganglion neurons and transported to the SC, where BDNF may be released and transferred to the postsynaptic neurons [52].
Localization (transported) of BDNF in retina associated with ganglion cysts
15) Confidence 0.65 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2664844 Disease Relevance 0.31 Pain Relevance 0.03
Using in vitro and in vivo models, we provide direct evidence that P2X(4)R stimulation leads to the release of BDNF from activated microglia and, most likely phosphorylation of the NR1 subunit of NMDA receptors in dorsal horn neurons of the spinal cord.
Localization (release) of BDNF in dorsal horn associated with nmda receptor, dorsal horn neuron and spinal cord
16) Confidence 0.65 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18971468 Disease Relevance 0.78 Pain Relevance 0.82
As mentioned earlier, this Met66 variant affects activity-dependent BDNF secretion.56,59 This is critical for dendritic trafficking and synaptic localization of BDNF.
Localization (localization) of BDNF
17) Confidence 0.65 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.59 Pain Relevance 0.46
mice both are resistant to the effects of antidepressants in the forced swim test, indicating that normal TrkB signaling is required for the behavioral effects typically produced by antidepressants.121

Antidepressant-like effect of BDNF

Localization (effect) of BDNF associated with antidepressant and eae
18) Confidence 0.65 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.60 Pain Relevance 0.80
Phenelzine, on the other hand, reversed the corticosterone-induced decrease in BDNF partially in the frontal cortex and completely in the hippocampus.
Localization (decrease) of BDNF in hippocampus associated with urological neuroanatomy and hippocampus
19) Confidence 0.65 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.47 Pain Relevance 0.86
As mentioned earlier, this Met66 variant affects activity-dependent BDNF secretion.56,59 This is critical for dendritic trafficking and synaptic localization of BDNF.
Localization (secretion.56,59) of BDNF
20) Confidence 0.65 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.51 Pain Relevance 0.45

General Comments

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