INT113926

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Context Info
Confidence 0.56
First Reported 2003
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 7
Total Number 9
Disease Relevance 3.15
Pain Relevance 4.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Bdnf) cytoplasmic membrane-bounded vesicle (Bdnf)
Anatomy Link Frequency
dorsal horn 4
Neuronal 2
retina 2
spinal cord dorsal horn 2
microglia 2
Bdnf (Mus musculus)
Pain Link Frequency Relevance Heat
antidepressant 124 100.00 Very High Very High Very High
substance P 10 100.00 Very High Very High Very High
Eae 8 100.00 Very High Very High Very High
Dorsal horn 16 99.64 Very High Very High Very High
Spinal cord 55 99.40 Very High Very High Very High
Pain 6 98.52 Very High Very High Very High
depression 146 98.32 Very High Very High Very High
nMDA receptor 3 97.36 Very High Very High Very High
Dorsal horn neuron 8 96.64 Very High Very High Very High
chemokine 8 95.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 4 99.16 Very High Very High Very High
Pain 6 98.52 Very High Very High Very High
Depression 190 98.32 Very High Very High Very High
Targeted Disruption 16 95.72 Very High Very High Very High
Nervous System Injury 22 92.76 High High
Neuropathic Pain 7 84.96 Quite High
Hyperalgesia 3 84.64 Quite High
INFLAMMATION 6 84.12 Quite High
Adhesions 3 72.32 Quite High
Shock 8 69.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using in vitro and in vivo models, we provide direct evidence that P2X(4)R stimulation leads to the release of BDNF from activated microglia and, most likely phosphorylation of the NR1 subunit of NMDA receptors in dorsal horn neurons of the spinal cord.
Positive_regulation (leads) of Localization (release) of BDNF in dorsal horn associated with nmda receptor, dorsal horn neuron and spinal cord
1) Confidence 0.56 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18971468 Disease Relevance 0.78 Pain Relevance 0.82
Further localization of TrkB occurs at the synaptic sites after neuroanal activity.55 Neuronal activity, therefore, is critical for synthesis and intracellular targeting of TrkB receptors.55 Thus, BDNF release and expression of TrkB receptors in a coordinated fashion are important for optimal synaptic response.
Positive_regulation (important) of Localization (release) of BDNF in Neuronal
2) Confidence 0.46 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.45 Pain Relevance 0.19
CAPS2c-expressing cells showed lower BDNF-releasing activity than CAPS2a- or 2b-expressing cells; however, CAPS2c-expressing cells also showed an increase in BDNF release in response to high-KCl stimulation (Figure 6).
Positive_regulation (increase) of Localization (release) of BDNF
3) Confidence 0.45 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1853102 Disease Relevance 0 Pain Relevance 0
In this study, we didn't find any enhanced motility of microglia after local application of MCP-1, FKN, BDNF, NGF, IL-1?
Spec (find) Positive_regulation (find) of Localization (application) of BDNF in microglia
4) Confidence 0.45 Published 2010 Journal Mol Pain Section Body Doc Link PMC2857828 Disease Relevance 0.18 Pain Relevance 0.63
mice both are resistant to the effects of antidepressants in the forced swim test, indicating that normal TrkB signaling is required for the behavioral effects typically produced by antidepressants.121

Antidepressant-like effect of BDNF

Spec (like) Positive_regulation (resistant) of Localization (effect) of BDNF associated with antidepressant and eae
5) Confidence 0.43 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.63 Pain Relevance 0.84
Using in vitro and in vivo models, we provide direct evidence that P2X(4)R stimulation leads to the release of BDNF from activated microglia and, most likely phosphorylation of the NR1 subunit of NMDA receptors in dorsal horn neurons of the spinal cord.
Spec (likely) Positive_regulation (activated) of Localization (release) of BDNF in dorsal horn associated with nmda receptor, dorsal horn neuron and spinal cord
6) Confidence 0.40 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18971468 Disease Relevance 0.79 Pain Relevance 0.85
BDNF injected into the retina may be internalized by retinal ganglion neurons and transported to the SC, where BDNF may be released and transferred to the postsynaptic neurons [52].
Positive_regulation (transferred) of Localization (released) of BDNF in retina associated with ganglion cysts
7) Confidence 0.40 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2664844 Disease Relevance 0.32 Pain Relevance 0.03
Using an in vitro slice preparation of the mouse spinal cord dorsal horn, we compared the release of substance P (SP) and BDNF with the activation of ERK in postsynaptic neurons.
Positive_regulation (activation) of Localization (release) of BDNF in spinal cord dorsal horn associated with dorsal horn, substance p and spinal cord
8) Confidence 0.36 Published 2003 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 14572451 Disease Relevance 0 Pain Relevance 0.90
As shown in Figure 6, the levels of BDNF released into the culture medium in response to high-KCl stimulation were increased approximately two-fold by the expression of CAPS2a or 2b compared with cells without exogenous CAPS2 expression.
Positive_regulation (increased) of Localization (released) of BDNF
9) Confidence 0.34 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1853102 Disease Relevance 0 Pain Relevance 0

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