INT113946

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Context Info
Confidence 0.10
First Reported 2003
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 0.37
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transducer activity (FLNA, OPRM1) plasma membrane (FLNA, OPRM1) Golgi apparatus (OPRM1)
endoplasmic reticulum (OPRM1) cytoplasm (FLNA) cytosol (FLNA)
Anatomy Link Frequency
tail 1
FLNA (Homo sapiens)
OPRM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
mu opioid receptor 36 100.00 Very High Very High Very High
opioid receptor 3 95.20 Very High Very High Very High
Opioid 3 54.44 Quite High
agonist 6 50.96 Quite High
Enkephalin 3 30.12 Quite Low
Disease Link Frequency Relevance Heat
Skin Cancer 6 90.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Results from yeast two-hybrid screening were confirmed by direct protein-protein binding and by coimmunoprecipitation of filamin and mu opioid receptor from cell lysates.
filamin Binding (coimmunoprecipitation) of mu opioid receptor associated with mu opioid receptor
1) Confidence 0.10 Published 2003 Journal Mol. Pharmacol. Section Abstract Doc Link 14573758 Disease Relevance 0.15 Pain Relevance 0.28
Interaction between the mu opioid receptor and filamin A is involved in receptor regulation and trafficking.
filamin Binding (Interaction) of mu opioid receptor associated with mu opioid receptor
2) Confidence 0.10 Published 2003 Journal Mol. Pharmacol. Section Title Doc Link 14573758 Disease Relevance 0.15 Pain Relevance 0.39
The carboxyl tail of the human mu opioid receptor was shown to bind the carboxyl terminal region of human filamin A, a protein known to couple membrane proteins to actin.
filamin Binding (bind) of mu opioid receptor in tail associated with mu opioid receptor
3) Confidence 0.09 Published 2003 Journal Mol. Pharmacol. Section Abstract Doc Link 14573758 Disease Relevance 0.07 Pain Relevance 0.22

General Comments

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