INT113960

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Context Info
Confidence 0.49
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 5.88
Pain Relevance 1.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (APOB) small molecule metabolic process (APOB) endoplasmic reticulum (APOB)
enzyme binding (APOB) lipid metabolic process (APOB) extracellular space (APOB)
Anatomy Link Frequency
plasma 2
T24 2
APOB (Homo sapiens)
Pain Link Frequency Relevance Heat
interstitial cystitis 7 99.16 Very High Very High Very High
Morphine 17 96.32 Very High Very High Very High
cytokine 4 94.04 High High
agonist 40 86.56 High High
Inflammation 29 86.00 High High
Potency 7 76.56 Quite High
antagonist 19 60.88 Quite High
Opioid 7 59.04 Quite High
mu opioid receptor 17 50.00 Quite Low
Enkephalin 4 41.16 Quite Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 129 100.00 Very High Very High Very High
Familial Combined Hyperlipidemia 127 99.96 Very High Very High Very High
Cardiovascular Disease 63 99.90 Very High Very High Very High
Dyslipidemia /

Combined Dyslipidemia

16 99.48 Very High Very High Very High
Interstitial Cystitis 7 99.16 Very High Very High Very High
Appetite Loss 6 98.06 Very High Very High Very High
Hyperlipidemia 12 97.78 Very High Very High Very High
Chronic Renal Failure 18 97.02 Very High Very High Very High
Bladder Cancer 1 95.76 Very High Very High Very High
Coronary Artery Disease 47 94.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, although in many conditions LDL cholesterol and apoB levels increase in parallel (e.g. familial hypercholesterolaemia), in ESRD patients, due to hypertriglyceridemia, malnutrition or metabolic disturbances, LDL-C levels are often phenomenically ‘normal,’ as in our study, yet apoB levels are rather elevated due to its overproduction and this results in the formation of a small, dense form of LDL (pattern B phenotype).
Positive_regulation (elevated) of Gene_expression (levels) of apoB associated with appetite loss, chronic renal failure and hyperlipidemia
1) Confidence 0.49 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716782 Disease Relevance 1.12 Pain Relevance 0.14
In our study, patients with prominent CVD had elevated serum apoB and Lp(a) levels and apoB/apoA-I ratio values, as well as lower serum levels of apoA-I compared to patients without prevalent CVD.
Positive_regulation (elevated) of Gene_expression (levels) of apoB associated with cardiovascular disease
2) Confidence 0.49 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716782 Disease Relevance 0.82 Pain Relevance 0
Such dyslipidemia is also characterized by increased levels of atherogenic lipoproteins including, elevated apo B, and small, dense LDL and HDL particles (Tchernof et al 1996).
Positive_regulation (increased) of Gene_expression (levels) of apo B associated with disorder of lipid metabolism
3) Confidence 0.39 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464751 Disease Relevance 1.63 Pain Relevance 0
There was a minor increase in the apoB/apoA1 ratios in both groups (Figure 4).
Positive_regulation (increase) of Gene_expression (ratios) of apoB
4) Confidence 0.37 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2768711 Disease Relevance 0.46 Pain Relevance 0
The association pattern of the tan ME with the FCHL component traits was characteristic of FCHL: elevated plasma levels of TC, TG and ApoB (TC correlation?
Positive_regulation (elevated) of Gene_expression (levels) of ApoB in plasma associated with familial combined hyperlipidemia and disorder of lipid metabolism
5) Confidence 0.31 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730565 Disease Relevance 0.86 Pain Relevance 0
Reducing number entry errors: solving a widespread, serious problem

Number entry is ubiquitous: it is required in many fields including science, healthcare, education, government, mathematics and finance.

Positive_regulation (required) of Gene_expression (science) of including
6) Confidence 0.03 Published 2010 Journal Journal of the Royal Society Interface Section Title Doc Link PMC2935596 Disease Relevance 0 Pain Relevance 0
Moreover, the lower level of expression of the mutant receptor could also contribute to this observation since it directly affects the extent of [35S] GTP?
Positive_regulation (contribute) of Gene_expression (expression) of mutant receptor
7) Confidence 0.02 Published 2003 Journal BMC Pharmacol Section Body Doc Link PMC317294 Disease Relevance 0 Pain Relevance 0.68
T24 cells transduced with a dominant-negative super-repressor IkappaB mutant (pAxCAmIkappaB-M) or wild-type adenoviral vectors in the presence or absence of rhTNF-alpha.
Positive_regulation (transduced) of Gene_expression (transduced) of mutant in T24
8) Confidence 0.02 Published 2003 Journal Urol. Res. Section Abstract Doc Link 14574533 Disease Relevance 0.75 Pain Relevance 0.57

General Comments

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