INT113962

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Context Info
Confidence 0.39
First Reported 2003
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.31
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (CREB1) mitochondrion (CREB1) Golgi apparatus (OPRM1)
endoplasmic reticulum (OPRM1) signal transducer activity (OPRM1) signal transduction (CREB1)
Anatomy Link Frequency
chondrocytes 1
OPRM1 (Homo sapiens)
CREB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 2 100.00 Very High Very High Very High
Opioid 2 99.98 Very High Very High Very High
Arthritis 1 76.00 Quite High
mu opioid receptor 1 75.00 Quite High
Inflammation 1 74.88 Quite High
analgesia 1 73.72 Quite High
Morphine 2 72.96 Quite High
Disease Link Frequency Relevance Heat
Osteoarthritis 2 81.88 Quite High
Arthritis 1 76.00 Quite High
INFLAMMATION 1 74.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The obtained results indicate that in human articular chondrocytes opioids affect, via the mu-opioid receptor, the transcription factor CREB which in turn can cause subsequent changes in gene expression.
mu-opioid receptor Regulation (affect) of CREB in chondrocytes associated with opioid receptor and opioid
1) Confidence 0.39 Published 2003 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 14575714 Disease Relevance 0.31 Pain Relevance 0.60

General Comments

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