INT113966

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Context Info
Confidence 0.31
First Reported 2003
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.76
Pain Relevance 1.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nisch) endosome (Nisch) plasma membrane (Nisch)
cytoplasm (Nisch)
Nisch (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 4 100.00 Very High Very High Very High
antagonist 2 100.00 Very High Very High Very High
Serotonin 8 99.92 Very High Very High Very High
tail-flick 4 97.60 Very High Very High Very High
Morphine 7 92.20 High High
Analgesic 1 91.44 High High
Pain threshold 5 88.64 High High
Intracerebroventricular 1 83.48 Quite High
analgesia 4 81.52 Quite High
tolerance 4 79.84 Quite High
Disease Link Frequency Relevance Heat
Pain 5 88.64 High High
Myelodysplastic Syndromes 4 73.24 Quite High
Disease 56 68.64 Quite High
Apoptosis 6 56.96 Quite High
Toxicity 4 21.48 Low Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low
Congenital Anomalies 2 5.00 Very Low Very Low Very Low
Cognitive Disorder 2 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 2 5.00 Very Low Very Low Very Low
Sprains And Strains 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These effects of DFMO and aminoguanidine were antagonized by idazoxan (3 mg/kg, i.p.), which is a selective antagonist of the imidazoline receptor.
Negative_regulation (antagonist) of imidazoline receptor associated with antagonist
1) Confidence 0.31 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 14575798 Disease Relevance 0.38 Pain Relevance 1.64
Dimebon also significantly inhibited Dopamine D1, D2S, D3 receptors, Imidazoline I2 receptor, Serotonin 5-HT2 and 5-HT2B receptors (70–80% inhibition).
Negative_regulation (inhibited) of Imidazoline I2 receptor associated with dopamine and serotonin
2) Confidence 0.01 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2577671 Disease Relevance 0.38 Pain Relevance 0.29

General Comments

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