INT113980

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Context Info
Confidence 0.05
First Reported 2003
Last Reported 2008
Negated 3
Speculated 1
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 7.16
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cald1) cytoplasm (Cald1)
Anatomy Link Frequency
smooth muscle 4
Cald1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cva 1 88.36 High High
Dismenorea 3 82.64 Quite High
Pain 1 55.84 Quite High
positron emission tomography 2 17.08 Low Low
palliative 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
nud 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Metaplasia 3 99.96 Very High Very High Very High
Endometrial Stromal Sarcoma 21 99.88 Very High Very High Very High
Uterine Fibroids 72 99.68 Very High Very High Very High
Leiomyosarcoma 18 99.36 Very High Very High Very High
Cancer 19 98.48 Very High Very High Very High
Smooth Muscle Tumor 9 96.04 Very High Very High Very High
Necrosis 3 88.84 High High
Hemorrhage 1 88.36 High High
Malignant Neoplastic Disease 8 85.28 High High
Dysmenorrhea 3 82.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunohistochemical studies showed weak membranous positivity for epithelial membrane antigen and focal cytoplasmic positivity for CD34; stains for smooth muscle actin, cytokeratin AE1/AE3, desmin, CD56, H-caldesmon, calponin, and S-100 protein were negative.
Neg (negative) Gene_expression (negative) of H-caldesmon in smooth muscle
1) Confidence 0.05 Published 2005 Journal Ann Diagn Pathol Section Abstract Doc Link 16084452 Disease Relevance 0.96 Pain Relevance 0.10
The expressions of OTR, CD10, h-caldesmon, calponin, smooth muscle actin, and desmin were analyzed in 10 conventional leiomyomas (LMs), 10 highly cellular leiomyomas (HCLs), eight leiomyosarcomas (LMSs), and nine ESSs.
Spec (analyzed) Gene_expression (expressions) of h-caldesmon in smooth muscle associated with endometrial stromal sarcoma, leiomyosarcoma and uterine fibroids
2) Confidence 0.02 Published 2003 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 14576480 Disease Relevance 1.47 Pain Relevance 0.08
The ESSs were negative for h-caldesmon and showed desmin positivity mainly in regions of smooth muscle metaplasia. h-Caldesmon, calponin, smooth muscle actin, and desmin were expressed in all LMs, HCLs, and LMSs except for one leiomyosarcoma with epithelioid features, which was negative for h-caldesmon and calponin.
Neg (negative) Gene_expression (negative) of h-caldesmon in smooth muscle associated with leiomyosarcoma, endometrial stromal sarcoma, uterine fibroids and metaplasia
3) Confidence 0.01 Published 2003 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 14576480 Disease Relevance 2.20 Pain Relevance 0.08
Evidence to this effect was as follows: a low mitotic index of less than 1 mitosis per 10 high-power fields (HPFs); a low MIB-1 index of 1%; and a positive immunohistochemistry reaction for oestrogen receptors, progesterone receptors, H-caldesmon and desmins.
Gene_expression (reaction) of H-caldesmon
4) Confidence 0.01 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2563016 Disease Relevance 0.39 Pain Relevance 0
The ESSs were negative for h-caldesmon and showed desmin positivity mainly in regions of smooth muscle metaplasia. h-Caldesmon, calponin, smooth muscle actin, and desmin were expressed in all LMs, HCLs, and LMSs except for one leiomyosarcoma with epithelioid features, which was negative for h-caldesmon and calponin.
Neg (except) Gene_expression (expressed) of h-Caldesmon in smooth muscle associated with leiomyosarcoma, endometrial stromal sarcoma, uterine fibroids and metaplasia
5) Confidence 0.01 Published 2003 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 14576480 Disease Relevance 2.15 Pain Relevance 0.07

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