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Context Info
Confidence 0.50
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 8.79
Pain Relevance 1.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TP63) nucleoplasm (TP63) anatomical structure formation involved in morphogenesis (TP63)
Golgi apparatus (TP63) nucleolus (TP63) nucleus (TP63)
Anatomy Link Frequency
B35 1
skin 1
uterine 1
TP63 (Homo sapiens)
TP63 - P1308L (1)
Pain Link Frequency Relevance Heat
Neuritis 10 99.84 Very High Very High Very High
psoriasis 55 96.96 Very High Very High Very High
Inflammation 39 96.12 Very High Very High Very High
Dismenorea 1 90.84 High High
Multiple sclerosis 18 87.48 High High
anesthesia 1 71.68 Quite High
Paroxysmal extreme pain disorder 32 66.68 Quite High
Etanercept 17 57.56 Quite High
antagonist 1 52.20 Quite High
sodium channel 9 51.84 Quite High
Disease Link Frequency Relevance Heat
Leiomyosarcoma 35 100.00 Very High Very High Very High
Uterine Fibroids 9 100.00 Very High Very High Very High
Optic Neuritis 10 99.84 Very High Very High Very High
Nasopharynx Cancer 145 99.50 Very High Very High Very High
Psoriasis 68 99.50 Very High Very High Very High
Metastasis 30 98.72 Very High Very High Very High
Cancer 143 98.60 Very High Very High Very High
Disease 64 98.16 Very High Very High Very High
Apoptosis 145 96.24 Very High Very High Very High
INFLAMMATION 39 96.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
All tumor cells showed the expected pattern of immunoreactivity, with positive results for the antimitochondrial antibody and p63, and negative results for the androgenic receptor antibody.
Positive_regulation (results) of p63 associated with cancer
1) Confidence 0.50 Published 2010 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Abstract Doc Link 20451836 Disease Relevance 0.54 Pain Relevance 0.07
If our observations are confirmed in other series, they would suggest that studies performed in STS patients should not only be stratified for LMS but also for uterine and non-uterine primary disease localisation and for gender.

Positive_regulation (stratified) of LMS in uterine associated with disease
2) Confidence 0.38 Published 2009 Journal Sarcoma Section Body Doc Link PMC2801456 Disease Relevance 0.40 Pain Relevance 0
The results of immunoprecipitation suggested a direct interaction between EBNA-5 and p63 protein in NPC, and this binding would increase the stability of p63.
Positive_regulation (increase) of p63 associated with nasopharynx cancer
3) Confidence 0.34 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1774581 Disease Relevance 1.17 Pain Relevance 0
The induction of TP63 most likely lead to the increased expression of BAX, APAF1, and caspase-9 seen in WTSTS cells.
Positive_regulation (induction) of TP63
4) Confidence 0.22 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 0.54 Pain Relevance 0
In humans, IL-23 is clearly elevated in psoriatic lesions as indicated by increased levels of both p19 and p40 (subunits of IL-23) mRNA in lesional skin as compared to non-lesional skin, but the mRNA levels of p35 (subunit of IL-12) are not.30 These data suggest that IL-23 appears to play a more dominant role than IL-12 in psoriasis.
Positive_regulation (increased) of p40 in skin associated with psoriasis
5) Confidence 0.06 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857612 Disease Relevance 1.01 Pain Relevance 0.40
We treated 9 patients with measurable LMS (primaries and
Positive_regulation (measurable) of LMS associated with leiomyosarcoma
6) Confidence 0.04 Published 2006 Journal Sarcoma Section Body Doc Link PMC1510952 Disease Relevance 1.66 Pain Relevance 0
The faster inactivation kinetics of P1308L may be due to enhanced activation of P1308L channels, since open-state fast-inactivation is coupled to the activation state of channels [27].
Positive_regulation (activation) of P1308L (P1308L)
7) Confidence 0.04 Published 2010 Journal Mol Pain Section Body Doc Link PMC2876140 Disease Relevance 0.15 Pain Relevance 0.09
All LMs and HCLs were strongly positive for OTR.
Positive_regulation (positive) of LMs associated with uterine fibroids
8) Confidence 0.03 Published 2003 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 14576480 Disease Relevance 2.14 Pain Relevance 0.09
HLA-B5, B51, B38, B27, and B35 were significantly increased in ON patients compared with control subjects.
Positive_regulation (increased) of B51 in B35 associated with neuritis
9) Confidence 0.02 Published 2005 Journal Eur. J. Neurol. Section Abstract Doc Link 15613143 Disease Relevance 1.19 Pain Relevance 0.97

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