INT113987

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Context Info
Confidence 0.23
First Reported 2003
Last Reported 2011
Negated 3
Speculated 0
Reported most in Body
Documents 29
Total Number 32
Disease Relevance 16.73
Pain Relevance 8.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IK) nucleus (IK) cell-cell signaling (IK)
Anatomy Link Frequency
neurons 4
lymphocytes 1
PSCs 1
urine 1
T-cell 1
IK (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 1091 100.00 Very High Very High Very High
Inflammation 544 99.98 Very High Very High Very High
methotrexate 12 99.70 Very High Very High Very High
agonist 148 99.40 Very High Very High Very High
antagonist 118 98.92 Very High Very High Very High
Neuropathic pain 3 98.68 Very High Very High Very High
fibrosis 69 98.66 Very High Very High Very High
dexamethasone 8 96.64 Very High Very High Very High
Neurotransmitter 3 95.12 Very High Very High Very High
aspirin 6 93.80 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 608 99.98 Very High Very High Very High
Herpes Simplex Virus 1190 99.82 Very High Very High Very High
Infection 539 99.82 Very High Very High Very High
Primary Sclerosing Cholangitis 2 99.80 Very High Very High Very High
Stress 30 99.70 Very High Very High Very High
Hemolysis 1 99.50 Very High Very High Very High
Edema 2 99.36 Very High Very High Very High
Disease 214 99.34 Very High Very High Very High
Diabetes Mellitus 19 99.12 Very High Very High Very High
Alzheimer's Dementia 1 99.02 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The following parameters were evaluated: cell growth and viability (light microscopy, lactate dehydrogenase release), calcium deposits (Alizarin Red S staining), expression of bone morphogenetic factors (real-time PCR).
Localization (release) of Red
1) Confidence 0.23 Published 2009 Journal Lasers Surg Med Section Body Doc Link 19347943 Disease Relevance 0 Pain Relevance 0
In both conditions (upright–RED and upright–LED, Fig. 6B), differences in preferred directions of individual neurons were distributed both toward CCW and CW directions, and there was no significant difference in preferred directions between upright and RED on one hand (mean ?
Neg (no) Localization (difference) of RED in neurons
2) Confidence 0.14 Published 2011 Journal Cerebral Cortex (New York, NY) Section Body Doc Link PMC3000568 Disease Relevance 0 Pain Relevance 0
In both conditions (upright–RED and upright–LED, Fig. 7B), differences in preferred directions of individual neurons were distributed both toward CCW and CW directions, and there was no significant difference in preferred directions between upright and RED on one hand (mean ?
Neg (no) Localization (difference) of RED in neurons
3) Confidence 0.14 Published 2011 Journal Cerebral Cortex (New York, NY) Section Body Doc Link PMC3000568 Disease Relevance 0 Pain Relevance 0
In both conditions (upright–RED and upright–LED, Fig. 8B), differences in preferred directions of individual neurons were distributed both toward CCW and CW directions, and there was no significant difference in preferred directions between upright and RED on one hand (mean ?
Neg (no) Localization (difference) of RED in neurons
4) Confidence 0.14 Published 2011 Journal Cerebral Cortex (New York, NY) Section Body Doc Link PMC3000568 Disease Relevance 0 Pain Relevance 0
In both conditions (upright–RED and upright–LED, Fig. 7B), differences in preferred directions of individual neurons were distributed both toward CCW and CW directions, and there was no significant difference in preferred directions between upright and RED on one hand (mean ?
Localization (upright) of RED in neurons
5) Confidence 0.14 Published 2011 Journal Cerebral Cortex (New York, NY) Section Body Doc Link PMC3000568 Disease Relevance 0 Pain Relevance 0
Results obtained revealed no co-localization of the green particle and red endo-lysosome after 1 h incubation, as shown in Figure 5, indicating that pSOD-HSA NP likely entered the cells via caveloae pathway.
Localization (localization) of red
6) Confidence 0.09 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2768759 Disease Relevance 0 Pain Relevance 0
There was a 15.1 sp/s larger response for red stimuli than green or blue (CI: 9.08 to 21.28, F = 13.25, p < 0.0001, Equation 4a).
Localization (response) of red
7) Confidence 0.09 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1925133 Disease Relevance 0 Pain Relevance 0
However, combination with tocotrienol not only attenuated the diabetic condition but also reversed neuropathic pain through modulation of oxidative-nitrosative stress, inflammatory cytokine release and caspase-3 in the diabetic rats and thus it may find clinical application to treat neuropathic pain in the diabetic patients.
Localization (release) of cytokine associated with stress, inflammation, diabetes mellitus, neuropathic pain and cytokine
8) Confidence 0.07 Published 2009 Journal Neuropharmacology Section Abstract Doc Link 19555701 Disease Relevance 2.28 Pain Relevance 0.87
Due to the synergistic action of IK,CCh and ICa, it is impossible to provide exact quantitative estimates on the relative importance of IK,CCh and ICa in the negative inotropic effect of CCh, even though IK,CCh seems to be more important.
Localization (importance) of IK
9) Confidence 0.06 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2894799 Disease Relevance 0.09 Pain Relevance 0.22
Surprisingly, despite evidence of unregulated activation, Rab7 disease mutants have normal subcellular localization and associate normally with LAMP2 (Fig. 5B) and LysoTracker Red (data not shown).
Localization (localization) of Red associated with disease
10) Confidence 0.04 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2830827 Disease Relevance 0.57 Pain Relevance 0
An exception can be tumors or lesions of the urothelium, which can bleed occultly prior to producing symptoms, or more rarely, chronic intravascular hemolysis, in which hemoglobin is released from damaged red cells into the plasma, where it is excreted in the urine, detectable as hemosiderin in the urine sediment.


Localization (released) of red in urine associated with cancer and hemolysis
11) Confidence 0.03 Published 2010 Journal Dig Dis Sci Section Body Doc Link PMC2822907 Disease Relevance 1.92 Pain Relevance 0.12
However, pre-operative administration of GH did not alter C-reactive protein (CRP), serum amyloid A (SAA) or interleukin-6 (IL-6, an inflammatory cytokine) release (Mealy et al 1998).
Localization (release) of cytokine associated with inflammation, alzheimer's dementia and cytokine
12) Confidence 0.02 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663454 Disease Relevance 0.97 Pain Relevance 0.13
Furthermore, we demonstrated an unprecedented immunosuppressive effect of AEA on IL-17 production, a typical cytokine that is released from the unique CD4+ T-cell subset T-helper 17.


Localization (released) of cytokine in T-cell associated with cytokine
13) Confidence 0.02 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2809084 Disease Relevance 0 Pain Relevance 0.47
Effect of AEA on cytokine release
Localization (release) of cytokine associated with cytokine
14) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2809084 Disease Relevance 0 Pain Relevance 0.44
Interestingly, 1.0 µM SR1 did not significantly antagonize the effect of AEA on cytokine release, whereas 1.0 µM SR2 did (TNF-?
Localization (release) of cytokine associated with cytokine
15) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2809084 Disease Relevance 0.18 Pain Relevance 0.29
Moreover, counterregulatory changes to cytokine release may result in abrogation, diminution, or an altered time course of cytokines following multiple dosing of a therapeutic.
Localization (release) of cytokine associated with cytokine
16) Confidence 0.01 Published 2010 Journal Toxicological Sciences Section Body Doc Link PMC2923281 Disease Relevance 0.66 Pain Relevance 0.27
Classically, cytokines were understood in the context of the immune response, whereby sequential cytokine secretion orchestrates inflammation and immunity.
Localization (secretion) of cytokine associated with inflammation and cytokine
17) Confidence 0.01 Published 2010 Journal Toxicological Sciences Section Body Doc Link PMC2923281 Disease Relevance 0.43 Pain Relevance 0.37
Flares in the skin surrounding the compound 48/80 sites decreased after the first pre-treatment but persisted to some extent after wheals had disappeared, suggesting that a reagent produced during mast cell activation (e.g., a cytokine or lipoxygenase product released from degranulated mast cells) triggered a residual flare.
Localization (released) of cytokine in mast cells
18) Confidence 0.01 Published 2004 Journal Inflamm. Res. Section Body Doc Link 15241566 Disease Relevance 0.08 Pain Relevance 0
Although the manifestations of fibrosis are tissue-specific, the underlying mechanism generally involves vascular damage and cytokine release [5-9].
Localization (release) of cytokine associated with fibrosis and cytokine
19) Confidence 0.01 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1891306 Disease Relevance 1.04 Pain Relevance 0.34
Ciglitazone alone only slightly affected cytokine-induced IL-8 secretion, however, the agonist significantly reduced IL-8 secretion from cells pre-treated with IL-4 [17].
Localization (secretion) of cytokine associated with agonist and cytokine
20) Confidence 0.01 Published 2005 Journal Respir Res Section Body Doc Link PMC1242255 Disease Relevance 0.39 Pain Relevance 0.44

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