INT113996

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Context Info
Confidence 0.72
First Reported 2003
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 23
Total Number 25
Disease Relevance 7.70
Pain Relevance 3.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (RS1) extracellular region (RS1) cell adhesion (RS1)
Anatomy Link Frequency
blood 2
osteoblast 1
spinal cord 1
brain 1
rider 1
RS1 (Homo sapiens)
RS1 - D66A (1) RS1 - D66N (1)
Pain Link Frequency Relevance Heat
Spinal cord 3 99.64 Very High Very High Very High
adenocard 8 98.48 Very High Very High Very High
agonist 195 93.52 High High
antagonist 51 91.92 High High
Migraine 46 91.24 High High
Inflammation 106 90.56 High High
lidocaine 6 90.48 High High
COX2 6 88.92 High High
Central nervous system 11 81.68 Quite High
local anesthetic 3 80.32 Quite High
Disease Link Frequency Relevance Heat
Coronary Artery Disease 35 99.90 Very High Very High Very High
Targeted Disruption 32 99.80 Very High Very High Very High
Esophageal Disease 72 99.34 Very High Very High Very High
Osteoporosis 8 99.28 Very High Very High Very High
Obesity 13 97.16 Very High Very High Very High
Asthma 130 97.12 Very High Very High Very High
Diabetes Mellitus 102 96.80 Very High Very High Very High
Familial Combined Hyperlipidemia 127 96.60 Very High Very High Very High
Hypertension 8 96.28 Very High Very High Very High
Bordatella Infection 11 95.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using the tetracycline transactivator (Tet) system, we have already made an Rs1 transgenic mouse in which Rs1 expression is driven by the osteoblast-specific Col1?
Gene_expression (expression) of Rs1 in osteoblast associated with targeted disruption and osteoporosis
1) Confidence 0.72 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2267039 Disease Relevance 0.28 Pain Relevance 0.07
The cell-surface expression of Rs1-D66A and Rs1-D66N was similar to that of Rs1 (Figure 6B), so the reduction in constitutive signaling was probably not linked to lower cell-surface expression.
Gene_expression (expression) of Rs1 (D66A)
2) Confidence 0.72 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2267039 Disease Relevance 0.08 Pain Relevance 0.07
We found only constitutive Gs signaling in Rs1 but did not observe any constitutive Gq signaling.
Gene_expression (signaling) of Rs1
3) Confidence 0.62 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2267039 Disease Relevance 0.25 Pain Relevance 0.10
Ligand-specific Gq signaling in Rs1
Gene_expression (signaling) of Rs1
4) Confidence 0.62 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2267039 Disease Relevance 0 Pain Relevance 0.06
Therefore, we could use drugs with distinct chemical structures (Figure S1) to activate Gs or Gs/Gq signaling of Rs1.
Gene_expression (signaling) of Rs1
5) Confidence 0.62 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2267039 Disease Relevance 0 Pain Relevance 0.04
The cell-surface expression of Rs1-D66A and Rs1-D66N was similar to that of Rs1 (Figure 6B), so the reduction in constitutive signaling was probably not linked to lower cell-surface expression.
Gene_expression (expression) of Rs1-D66N (D66N)
6) Confidence 0.56 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2267039 Disease Relevance 0.08 Pain Relevance 0.07
Fortunately, we can use conditional expression systems such as the tetracycline transactivator system to control Rs1 expression and constitutive activation.
Gene_expression (expression) of Rs1
7) Confidence 0.56 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2267039 Disease Relevance 0.14 Pain Relevance 0.24
Of the 12 Rs1-5-HT2C chimeras that are expressed on the cell surface, none of the i2 or i3 chimeras showed any Gs or Gq signaling.
Gene_expression (expressed) of Rs1
8) Confidence 0.56 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2267039 Disease Relevance 0 Pain Relevance 0.10
When values were fully learned, Vi(SS)=RS??
Gene_expression (learned) of RS
9) Confidence 0.40 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC3004435 Disease Relevance 0 Pain Relevance 0
Reins length was also influential: the more time the rider spent with long reins, the less the horse was observed with a high (Spearman correlation test, rs?
Gene_expression (less) of rs in rider
10) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2860978 Disease Relevance 0 Pain Relevance 0
D'| > 0.7), the most common SNP (rs4806481) was selected for genotyping.
Gene_expression (selected) of rs4806481
11) Confidence 0.15 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2954844 Disease Relevance 0.87 Pain Relevance 0.07
D'| > 0.7), the most common SNP (rs4806481) was selected for genotyping.
Gene_expression (selected) of rs4806481
12) Confidence 0.08 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2954844 Disease Relevance 0.89 Pain Relevance 0.07
Actually they tested whether the susceptibility between CAD and rs2891168 changed significantly in subgroups of CAD patients (regular smoker, sex, age, obesity, diabetes and hypertension); none of these potential confounders affected the associations.
Gene_expression (changed) of rs2891168 associated with coronary artery disease, diabetes mellitus, hypertension and obesity
13) Confidence 0.06 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2871267 Disease Relevance 1.02 Pain Relevance 0
For instance HLA-DM (rs151719), a chaperone binder for nascent MHC molecules, could differentially modulate peptide binding and thus antigen presentation.
Gene_expression (molecules) of rs151719
14) Confidence 0.05 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2791168 Disease Relevance 0.83 Pain Relevance 0.11
Genomic DNA was extracted from the whole blood and the SNPs rs2243193, rs2981572, and rs1150253 were analyzed by the tetra-primer ARMS-PCR method as described previously [6,23,24].
Spec (analyzed) Gene_expression (analyzed) of rs2243193 in blood
15) Confidence 0.01 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2648955 Disease Relevance 0 Pain Relevance 0
Genomic DNA was extracted from the whole blood and the SNPs rs2243193, rs2981572, and rs1150253 were analyzed by the tetra-primer ARMS-PCR method as described previously [6,23,24].
Spec (analyzed) Gene_expression (analyzed) of rs1150253 in blood
16) Confidence 0.01 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2648955 Disease Relevance 0 Pain Relevance 0
Only the database SNPs rs7305115 and rs4290270 could be detected at the genomic level and were confirmed as genuine SNPs (Figure 2A and 2B).
Gene_expression (detected) of rs7305115
17) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2813293 Disease Relevance 0.09 Pain Relevance 0.23
Finally, additional markers did not contribute significant effects to the main effects of both SNPs (rs2421853 and rs245858).
Gene_expression (effects) of rs2421853
18) Confidence 0.01 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2652017 Disease Relevance 0.23 Pain Relevance 0
However, the SNP rs2195450, was the only SNP found in Hardy-Weinberg disequilibrium (DHW) both in controls and in patients (p < 0.05).
Gene_expression (found) of rs2195450
19) Confidence 0.01 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2909201 Disease Relevance 0.43 Pain Relevance 0.43
We observed a marginally significant prediction of FADS1 expression (rs174547 correlation?
Gene_expression (expression) of rs174547
20) Confidence 0.01 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730565 Disease Relevance 0.74 Pain Relevance 0

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