INT113999

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Context Info
Confidence 0.64
First Reported 2003
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 2.41
Pain Relevance 2.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (RS1) extracellular region (RS1) cell adhesion (RS1)
Anatomy Link Frequency
rider 1
RS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Serotonin 56 100.00 Very High Very High Very High
COX2 3 100.00 Very High Very High Very High
agonist 168 99.60 Very High Very High Very High
adenocard 2 97.68 Very High Very High Very High
lidocaine 2 96.68 Very High Very High Very High
Inflammation 32 91.84 High High
antagonist 43 87.52 High High
local anesthetic 1 86.52 High High
Spinal cord 1 86.00 High High
Migraine 46 79.32 Quite High
Disease Link Frequency Relevance Heat
Bordatella Infection 8 99.00 Very High Very High Very High
Esophageal Disease 36 98.90 Very High Very High Very High
Targeted Disruption 28 97.28 Very High Very High Very High
Pneumonia 36 94.96 High High
Disease 14 94.68 High High
Non-small-cell Lung Cancer 8 92.92 High High
INFLAMMATION 38 91.84 High High
Toxicity 20 85.60 High High
Headache 45 79.32 Quite High
Lung Cancer 4 77.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For instance, we could use GR125487 to activate Rs1 while suppressing the basal activity of wildtype 5-HT4.
Positive_regulation (activate) of Rs1
1) Confidence 0.64 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2267039 Disease Relevance 0.07 Pain Relevance 0.17
Many of the Rs1 agonists used in this study activated Rs1 with an EC50 in the nanomolar range, allowing to us activate Rs1 effectively.
Positive_regulation (activate) of Rs1 associated with agonist
2) Confidence 0.64 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2267039 Disease Relevance 0.12 Pain Relevance 0.14
Many of the Rs1 agonists used in this study activated Rs1 with an EC50 in the nanomolar range, allowing to us activate Rs1 effectively.
Positive_regulation (activated) of Rs1 associated with agonist
3) Confidence 0.56 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2267039 Disease Relevance 0.12 Pain Relevance 0.14
Having an abundant selection of ligands for Rs1 helped us find strong evidence of ligand-induced functional selectivity on Rs1.
Positive_regulation (induced) of Rs1
4) Confidence 0.46 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2267039 Disease Relevance 0.17 Pain Relevance 0.13
The first receptor in this series, 5-HT4-D100A or Rs1 (RASSL serotonin 1), is not activated by its endogenous agonist, serotonin, but is selectively activated by the small synthetic molecules GR113808, GR125487, and RO110-0235.
Neg (not) Positive_regulation (activated) of Rs1 associated with agonist and serotonin
5) Confidence 0.43 Published 2007 Journal PLoS ONE Section Abstract Doc Link PMC2267039 Disease Relevance 0 Pain Relevance 0.19
Since Gq signaling of Rs1-C-5-HT2C was activated by cisapride, zacopride, and RS23597 but not by serotonin, we named it Rs1.1 (Table 1).
Neg (not) Positive_regulation (activated) of Rs1 associated with serotonin
6) Confidence 0.43 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2267039 Disease Relevance 0 Pain Relevance 0.05
Finally, this new series of RASSLs may make it possible to perform in vivo studies in which Rs1 is activated with minimal side effects.
Positive_regulation (activated) of Rs1
7) Confidence 0.43 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2267039 Disease Relevance 0.17 Pain Relevance 0.22
Note that in this graph we have manipulated only RS for convenience; similar plots can be generated by manipulating any of these task parameters: RS, DS, RL, and DL.
Positive_regulation (manipulated) of RS
8) Confidence 0.30 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC3004435 Disease Relevance 0 Pain Relevance 0
Hands positions were correlated with the horses' neck height and shape: the more the rider was with low hands, the more the horse exhibited a round neck shape (Spearman correlation test, rs?
Positive_regulation (exhibited) of rs in rider
9) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2860978 Disease Relevance 0 Pain Relevance 0
For esophagitis risk, nine SNPs were associated with a 1.5- to 4-fold increase in risk, including three PTGS2 (COX2) variants: rs20417 (HR:1.93, 95% CI:1.10–3.39), rs5275 (HR:1.58, 95% CI:1.09–2.27), and rs689470 (HR:3.38, 95% CI:1.09–10.49).
Positive_regulation (increase) of rs689470 associated with esophageal disease and cox2
10) Confidence 0.01 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2928273 Disease Relevance 1.33 Pain Relevance 0.17
For all SNPs, about 20 subjects were randomly selected and sequenced; for rs2195450 the sample was increased to 100 subjects.
Positive_regulation (increased) of rs2195450
11) Confidence 0.01 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2909201 Disease Relevance 0.34 Pain Relevance 0.44
Activated A1Rs couple to adenylate cyclase via the pertussis toxin sensitive Galphai protein, thereby decreasing cyclic adenosine monophosphate formation.
Positive_regulation (Activated) of A1Rs associated with adenocard and bordatella infection
12) Confidence 0.01 Published 2003 Journal Anesthesiology Section Abstract Doc Link 14576545 Disease Relevance 0.10 Pain Relevance 0.40

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