INT114

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Context Info
Confidence 0.48
First Reported 1976
Last Reported 2010
Negated 9
Speculated 11
Reported most in Abstract
Documents 139
Total Number 150
Disease Relevance 23.00
Pain Relevance 103.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprl1) plasma membrane (Oprl1) signal transducer activity (Oprl1)
Anatomy Link Frequency
brain 12
striatum 2
hippocampus 2
cortex 2
MVD 2
Oprl1 (Mus musculus)
Pain Link Frequency Relevance Heat
opiate 338 100.00 Very High Very High Very High
Opioid 237 100.00 Very High Very High Very High
orphanin 195 100.00 Very High Very High Very High
Morphine 194 100.00 Very High Very High Very High
narcan 162 100.00 Very High Very High Very High
Buprenorphine 143 100.00 Very High Very High Very High
agonist 125 100.00 Very High Very High Very High
opioid receptor 99 100.00 Very High Very High Very High
antagonist 90 100.00 Very High Very High Very High
Enkephalin 87 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Bacterial Infection 4 99.92 Very High Very High Very High
Thyroid Disease 2 99.92 Very High Very High Very High
Parkinson's Disease 4 99.84 Very High Very High Very High
Pain 232 99.80 Very High Very High Very High
Obesity 66 99.62 Very High Very High Very High
Catalepsy 2 99.56 Very High Very High Very High
Opiate Addiction 21 99.50 Very High Very High Very High
Convulsion 15 99.36 Very High Very High Very High
Respiratory Failure 8 99.34 Very High Very High Very High
Drug Dependence 6 99.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
N/OFQ and morphine bind to opioid receptor-like 1 (ORL1) receptor and muopioid receptor respectively.
opioid receptor-like 1 Binding (bind) of
1) Confidence 0.48 Published 2005 Journal Indian J. Med. Res. Section Abstract Doc Link 15802762 Disease Relevance 0 Pain Relevance 0.84
These findings, together with evidence for redox modification of opiate receptor binding in vitro, suggest that a mechanism of oxidation-reduction of thiols may modulate opiate receptor function.
opiate receptor Binding (binding) of associated with opiate
2) Confidence 0.48 Published 1980 Journal Science Section Abstract Doc Link 6246583 Disease Relevance 0 Pain Relevance 0.82
In the triple knockout brains all labelling was completely absent, suggesting that at this concentration there is no binding to ORL1 sites.
ORL1 Neg (no) Binding (binding) of in brains associated with targeted disruption
3) Confidence 0.48 Published 2005 Journal Neuropharmacology Section Abstract Doc Link 15695161 Disease Relevance 0.42 Pain Relevance 0.70
At the end of a 4-week period, animals were sacrificed and opiate receptor binding determined.
opiate receptor Spec (determined) Binding (binding) of associated with opiate
4) Confidence 0.48 Published 1989 Journal J Am Coll Nutr Section Abstract Doc Link 2538498 Disease Relevance 0.56 Pain Relevance 0.23
The effects of dietary sucrose on opiate receptor binding in genetically obese (ob/ob) and lean mice.
opiate receptor Binding (binding) of associated with obesity and opiate
5) Confidence 0.48 Published 1989 Journal J Am Coll Nutr Section Title Doc Link 2538498 Disease Relevance 0.81 Pain Relevance 0.34
The opiate receptor binding to whole brain synaptic membranes obtained from mice subjected to acute and chronic morphine administration and precipitated withdrawal was investigated. 2.
opiate receptor Binding (binding) of in brain associated with opiate, withdrawal and morphine
6) Confidence 0.48 Published 1982 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 6287530 Disease Relevance 0 Pain Relevance 0.55
Opioid receptor-like 1 (ORL1) receptor binding and the biological properties of Ac-Arg-Tyr-Tyr-Arg-Ile-Arg-NH2 and its analogs.
ORL1 Binding (binding) of associated with opioid receptor
7) Confidence 0.48 Published 2007 Journal J. Pept. Sci. Section Title Doc Link 17712865 Disease Relevance 0 Pain Relevance 0.47
INTRODUCTION: Radiopharmaceuticals that can bind selectively the kappa-opioid receptor may present opportunities for staging clinical brain disorders and evaluating the efficiency of new therapies related to stroke, neurodegenerative diseases or opiate addiction.
kappa-opioid receptor Binding (bind) of in brain associated with addiction, stroke, brain disease, kappa opioid receptor, opiate and neurodegenerative disease
8) Confidence 0.48 Published 2008 Journal Nucl. Med. Biol. Section Abstract Doc Link 18589300 Disease Relevance 0.38 Pain Relevance 0.45
The binding of [(11)C]-MeJDTic to kappa-opioid receptor was investigated ex vivo by biodistribution and competition studies using nonfasted male CD1 mice.
kappa-opioid receptor Binding (binding) of
9) Confidence 0.48 Published 2008 Journal Nucl. Med. Biol. Section Body Doc Link 18589300 Disease Relevance 0 Pain Relevance 0
Chase studies with U50,488 (a kappa referring agonist), morphine (a mu agonist) and naltrindole (a delta antagonist) demonstrated that this uptake was the result of specific binding to the kappa-opioid receptor.
kappa-opioid receptor Binding (binding) of
10) Confidence 0.48 Published 2008 Journal Nucl. Med. Biol. Section Body Doc Link 18589300 Disease Relevance 0 Pain Relevance 0
The displacement of 3H-diprenorphine by naloxone and carfentanil in vivo showed no differences in the striatum and thalamus suggesting that 3H-diprenorphine binds only to one opiate receptor subtype in vivo.
opiate receptor Binding (binds) of in thalamus associated with narcan, opiate and thalamus
11) Confidence 0.48 Published 1986 Journal Life Sci. Section Abstract Doc Link 3010021 Disease Relevance 0 Pain Relevance 0.79
The result shows that the analgesic potency of the derivatives of this series is mainly dependent on binding affinity for opiate receptor.
opiate receptor Binding (affinity) of associated with analgesic, opiate and potency
12) Confidence 0.48 Published 1981 Journal Sci. Sin. Section Abstract Doc Link 6264594 Disease Relevance 0 Pain Relevance 0.81
These compounds demonstrated activity in the mouse abdominal constriction test and many were active in the mouse tail-flick test. trans-3-(2-Bromophenyl)octahydroindolizine (2a) did not bind to the opiate receptor nor did it affect arachidonate metabolism. 3-Aryloctahydroindolizines were prepared by catalytic hydrogenation of 1-aryl-3-(2-pyridinyl)-2-propen-1-ones.
opiate receptor Neg (not) Binding (bind) of in tail associated with tail-flick and opiate
13) Confidence 0.48 Published 1992 Journal J. Med. Chem. Section Abstract Doc Link 1495016 Disease Relevance 0 Pain Relevance 0.40
Ethanol acutely inhibited opiate receptor binding, but after chronic exposure the cells exhibited an apparent adaptive increase in the number of opiate binding sites; this was reversible when ethanol was withdrawn.
opiate receptor Binding (binding) of associated with opiate
14) Confidence 0.48 Published 1984 Journal Ciba Found. Symp. Section Abstract Doc Link 6563992 Disease Relevance 0.42 Pain Relevance 0.58
In addition, the regional distribution of opiate receptor binding using 3H-diprenorphine, 3H-naloxone and 3H-lofentanil was measured.
opiate receptor Binding (binding) of associated with narcan and opiate
15) Confidence 0.48 Published 1986 Journal Life Sci. Section Abstract Doc Link 3010021 Disease Relevance 0 Pain Relevance 0.76
Endogenous opioids have been reported to elicit some of the pathophysiologic responses to endotoxic shock by binding to the delta-opiate receptor.
delta-opiate receptor Binding (binding) of associated with endogenous opioid, opiate and bacterial infection
16) Confidence 0.48 Published 1987 Journal Brain Behav. Immun. Section Abstract Doc Link 3330673 Disease Relevance 0.25 Pain Relevance 0.28
Nociceptin-stimulated GTPgammaS binding was markedly observed in amygdala, hippocampal pyramidal cell layers, temporal and entorhinal cortex, infralimbic organ, anterior olfactory nucleus, and rostral part of thalamus.
Nociceptin-stimulated GTPgammaS Binding (binding) of in pyramidal cell associated with pyramidal cell, orphanin, thalamus and amygdala
17) Confidence 0.48 Published 1997 Journal Neurosci. Lett. Section Abstract Doc Link 9453228 Disease Relevance 0 Pain Relevance 0.58
Naloxazone, a long-acting opiate antagonist: effects on analgesia in intact animals and on opiate receptor binding in vitro.
opiate receptor Binding (binding) of associated with antagonist, narcan, opiate and analgesia
18) Confidence 0.48 Published 1980 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 6105201 Disease Relevance 0 Pain Relevance 1.24
The ability of the metal salts to potentiate the affinity of opiate ligands to the appropriate receptors is effectuated via interaction of metal cation with the specific opiate receptor site.
opiate receptor site Binding (interaction) of associated with opiate
19) Confidence 0.48 Published 1985 Journal Biull Eksp Biol Med Section Abstract Doc Link 2994778 Disease Relevance 0 Pain Relevance 0.80
In mouse brain cortex membranes, the binding of the ORL1 receptor agonist [3H]nociceptin was equipotently inhibited by Mr 2266 and its enantiomer Mr 2267 (pK(i) 4.82 and 5.14, respectively), whereas the binding of the kappa-opioid receptor agonist [3H]U-69,593 was inhibited by Mr 2266 more potently (pK(i) 9.11) than by its enantiomer Mr 2267 (pK(i)7.15).
ORL1 receptor Binding (binding) of in cortex associated with orphanin, kappa opioid receptor, agonist and opioid
20) Confidence 0.48 Published 1999 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 9933145 Disease Relevance 0 Pain Relevance 0.96

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