INT114007

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Context Info
Confidence 0.03
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 1.09

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signal transduction (Oprm1) plasma membrane (Oprm1) signal transducer activity (Oprm1)
Crygs (Mus musculus)
Oprm1 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 2 99.18 Very High Very High Very High
Dynorphin 2 98.56 Very High Very High Very High
Enkephalin 2 97.32 Very High Very High Very High
Opioid 4 94.28 High High
Potency 4 93.92 High High
mu opioid receptor 4 75.00 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dynorphin A, beta-endorphin and morphine were most effective in stimulating [35S]GTPgammaS binding in MOR-1E, while M6G and fentanyl were most effective in MOR-1 expressing cells.
GTPgammaS Binding (binding) of MOR-1E associated with dynorphin and morphine
1) Confidence 0.03 Published 2004 Journal Synapse Section Abstract Doc Link 14579421 Disease Relevance 0 Pain Relevance 0.55
This was most prominent with beta-endorphin, which stimulated [35S]GTPgammaS binding in the MOR-1E expressing cells to a greater degree than [D-Ala2,MePhe4,Gly(ol)5]enkephalin (DAMGO; 130%) and was far less effective than DAMGO in MOR-1C cells (44%).
GTPgammaS Binding (binding) of MOR-1E associated with enkephalin
2) Confidence 0.03 Published 2004 Journal Synapse Section Abstract Doc Link 14579421 Disease Relevance 0 Pain Relevance 0.54

General Comments

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