INT114010

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Context Info
Confidence 0.75
First Reported 2003
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 1.69
Pain Relevance 1.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Itga7) cytoplasm (Itga7)
Anatomy Link Frequency
neuronal 1
paw 1
Itga7 (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 2 100.00 Very High Very High Very High
agonist 9 99.08 Very High Very High Very High
Nicotine 11 98.84 Very High Very High Very High
Perioperative pain 4 98.84 Very High Very High Very High
Kappa opioid receptor 1 94.28 High High
Antinociceptive 4 90.20 High High
ischemia 1 87.32 High High
Analgesic 4 86.72 High High
antinociception 1 74.32 Quite High
Hippocampus 1 58.00 Quite High
Disease Link Frequency Relevance Heat
Post Operative Pain 4 98.84 Very High Very High Very High
Sprains And Strains 4 97.66 Very High Very High Very High
Alzheimer's Dementia 8 97.60 Very High Very High Very High
Targeted Disruption 2 97.50 Very High Very High Very High
Neurodegenerative Disease 1 88.76 High High
Cv Unclassified Under Development 1 87.32 High High
Cognitive Disorder 4 82.32 Quite High
Convulsion 1 77.20 Quite High
Hypothermia 1 75.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Alpha 7-type nicotinic acetylcholine receptor and prodynorphin mRNA expression after administration of (-)-nicotine and U-50,488H in beta-amyloid peptide (25-35)-treated mice.
Gene_expression (expression) of Alpha 7 associated with nicotine, alzheimer's dementia and enkephalin
1) Confidence 0.75 Published 2004 Journal Ann. N. Y. Acad. Sci. Section Title Doc Link 15542756 Disease Relevance 0.86 Pain Relevance 0.54
Two series of knockin mouse strains have been constructed with point mutations that result in hypersensitive neuronal nicotinic acetylcholine receptors containing alpha 4- or alpha 7-subunits.
Gene_expression (containing) of alpha 7 in neuronal associated with targeted disruption and sprains and strains
2) Confidence 0.65 Published 2003 Journal Curr Opin Drug Discov Devel Section Abstract Doc Link 14579512 Disease Relevance 0.56 Pain Relevance 0.22
METHODS: After paw incision, mice were tested for heat latency and pressure threshold before and after treatment with a dose range of ligands selective for alpha 4 beta 2 and alpha 7 containing nicotinic receptors.
Gene_expression (containing) of alpha 7 in paw
3) Confidence 0.65 Published 2008 Journal Anesth. Analg. Section Body Doc Link 18713928 Disease Relevance 0.09 Pain Relevance 0
In an effort to determine what nicotinic subtypes might be targeted in future clinical studies, we tested agonists selective for alpha 4 beta 2 and alpha 7 containing nicotinic receptors in a mouse model of postoperative pain.
Gene_expression (containing) of alpha 7 associated with agonist and perioperative pain
4) Confidence 0.65 Published 2008 Journal Anesth. Analg. Section Abstract Doc Link 18713928 Disease Relevance 0.17 Pain Relevance 0.56

General Comments

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