INT114011

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Context Info
Confidence 0.45
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 6.12
Pain Relevance 2.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (ATP1A2) plasma membrane (ATP1A2) locomotion (ATP1A2)
transmembrane transport (ATP1A2) cytoplasm (ATP1A2)
ATP1A2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Migraine 27 100.00 Very High Very High Very High
sodium channel 1 100.00 Very High Very High Very High
adenocard 1 100.00 Very High Very High Very High
Pain 1 89.84 High High
bDMF 21 82.16 Quite High
long-term potentiation 1 73.04 Quite High
depression 1 60.88 Quite High
imagery 1 49.80 Quite Low
Central nervous system 1 25.00 Low Low
Calcium channel 1 23.76 Low Low
Disease Link Frequency Relevance Heat
Migraine With Aura 8 100.00 Very High Very High Very High
Hypoxia 24 99.98 Very High Very High Very High
Headache 24 99.20 Very High Very High Very High
Toxicity 6 94.96 High High
Stress 6 91.60 High High
Altitude Sickness 65 91.44 High High
Pressure And Volume Under Development 22 90.72 High High
Syndrome 12 89.84 High High
Disease 126 88.80 High High
Neuropathic Pain 1 88.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additional effects include inhibition of sodium-potassium-adenosine triphosphatase and binding to sulfhydryl groups.
Negative_regulation (inhibition) of sodium-potassium-adenosine triphosphatase associated with adenocard
1) Confidence 0.45 Published 2003 Journal Toxicol Rev Section Abstract Doc Link 14579545 Disease Relevance 0.95 Pain Relevance 0.14
While the downregulation of ATP1A2 has been linked to migraine-related conditions [35], the effects of its upregulation have not been documented.
Negative_regulation (downregulation) of ATP1A2 associated with migraine
2) Confidence 0.40 Published 2008 Journal Genome Biol Section Body Doc Link PMC2760875 Disease Relevance 0.78 Pain Relevance 0.33
Mutations in three genes have been described in FHM patients: CACNA1A (FHM1), ATP1A2 (FHM2) and SCN1A (FHM3).
Negative_regulation (described) of ATP1A2 associated with migraine
3) Confidence 0.25 Published 2008 Journal Cephalalgia Section Abstract Doc Link 18644040 Disease Relevance 1.31 Pain Relevance 0.95
Mutations in three genes have been described in FHM patients: CACNA1A (FHM1), ATP1A2 (FHM2) and SCN1A (FHM3).
Negative_regulation (described) of FHM2 associated with migraine
4) Confidence 0.25 Published 2008 Journal Cephalalgia Section Abstract Doc Link 18644040 Disease Relevance 1.32 Pain Relevance 0.95
Hypoxia inhibits the activity of apical epithelial sodium channels (ENaCs) and of the basolateral sodium-potassium ATPase pumps.
Negative_regulation (inhibits) of sodium-potassium ATPase associated with hypoxia and sodium channel
5) Confidence 0.09 Published 2010 Journal Indian Journal of Occupational and Environmental Medicine Section Body Doc Link PMC2923424 Disease Relevance 1.77 Pain Relevance 0.05

General Comments

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