INT114014

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Context Info
Confidence 0.69
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 13
Total Number 13
Disease Relevance 7.77
Pain Relevance 7.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (P2rx1) plasma membrane (P2rx1) protein complex (P2rx1)
Anatomy Link Frequency
Microglial cells 6
skin 4
sensory neurons 2
brain 2
brainstem 2
P2rx1 (Mus musculus)
Pain Link Frequency Relevance Heat
Cancer pain 6 99.74 Very High Very High Very High
Dorsal horn 3 99.68 Very High Very High Very High
agonist 8 99.40 Very High Very High Very High
Neuropathic pain 19 98.60 Very High Very High Very High
medulla 9 98.52 Very High Very High Very High
Calcitonin gene-related peptide 27 98.12 Very High Very High Very High
Brush evoked pain 10 97.00 Very High Very High Very High
allodynia 4 96.96 Very High Very High Very High
Spinal cord 22 96.88 Very High Very High Very High
gABA 10 93.96 High High
Disease Link Frequency Relevance Heat
Nociception 6 100.00 Very High Very High Very High
Cancer Pain 6 99.74 Very High Very High Very High
Nervous System Injury 28 99.72 Very High Very High Very High
Neuropathic Pain 34 98.60 Very High Very High Very High
Hypertrophy 1 95.60 Very High Very High Very High
Skin Cancer 8 94.84 High High
Inflammatory Pain 2 88.84 High High
Headache 6 88.00 High High
Ganglion Cysts 7 87.92 High High
Breast Cancer 2 85.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that ATP and P2X, especially P2X(3), receptors are involved in skin cancer pain, due to the increased release of ATP and increased expression of P2X(3) receptors in the sensory neurons.
Positive_regulation (increased) of Gene_expression (expression) of P2X in skin associated with cancer pain
1) Confidence 0.69 Published 2010 Journal Eur. J. Neurosci. Section Abstract Doc Link 20525075 Disease Relevance 1.11 Pain Relevance 0.39
Those expressed on peripheral terminals are activated in response to both nociceptive and innocuous stimuli, whereas those at central terminals ("central terminal P2X receptors") play an important role in modulating sensory transmission to the spinal cord dorsal horn.
Positive_regulation (activated) of Gene_expression (expressed) of P2X in spinal cord dorsal horn associated with nociception, dorsal horn and spinal cord
2) Confidence 0.50 Published 2003 Journal Neuroscientist Section Abstract Doc Link 14580121 Disease Relevance 0.18 Pain Relevance 0.35
This process is mediated via changes in the expression and function of P2X(3) receptors initially through enhanced trafficking and, later, perhaps through augmented synthesis of P2X(3) receptors.
Positive_regulation (augmented) of Gene_expression (synthesis) of P2X
3) Confidence 0.49 Published 2008 Journal J. Biol. Chem. Section Abstract Doc Link 18460469 Disease Relevance 0.51 Pain Relevance 0.64
Increased P2X(3) receptor synthesis was partly mediated by endogenous brain-derived neurotrophic factor (BDNF) because of its block by anti-BDNF antibodies and mimicry by exogenous BDNF.
Positive_regulation (Increased) of Gene_expression (synthesis) of P2X in brain
4) Confidence 0.49 Published 2008 Journal J. Biol. Chem. Section Abstract Doc Link 18460469 Disease Relevance 0.37 Pain Relevance 0.62
The present data indicate a novel mechanism for enhancing P2X(3) receptor expression and function in trigeminal sensory neurons by CGRP via CREB phosphorylation.
Positive_regulation (enhancing) of Gene_expression (expression) of P2X in sensory neurons associated with calcitonin gene-related peptide
5) Confidence 0.49 Published 2008 Journal J. Biol. Chem. Section Abstract Doc Link 18460469 Disease Relevance 0.07 Pain Relevance 0.43
These results suggest that ATP and P2X, especially P2X(3), receptors are involved in skin cancer pain, due to the increased release of ATP and increased expression of P2X(3) receptors in the sensory neurons.
Positive_regulation (increased) of Gene_expression (expression) of P2X in skin associated with cancer pain
6) Confidence 0.47 Published 2010 Journal Eur. J. Neurosci. Section Abstract Doc Link 20525075 Disease Relevance 1.10 Pain Relevance 0.38
Microglial cells from lyn(-/-) mice showed a deficit in their ability to increase P2X(4)R expression in response to fibronectin, a factor implicated as a microglial P2X(4)R upregulator in allodynia.
Positive_regulation (increase) of Gene_expression (expression) of P2X in Microglial cells associated with allodynia
7) Confidence 0.39 Published 2008 Journal Glia Section Abstract Doc Link 17918263 Disease Relevance 1.07 Pain Relevance 0.84
Taken together with the results of our previous study showing an increase in the spinal fibronectin level after nerve injury, the present results suggest that the fibronectin/integrin system participates in the upregulation of P2X(4)R expression after nerve injury and subsequent neuropathic pain.
Positive_regulation (upregulation) of Gene_expression (expression) of P2X in nerve associated with nervous system injury and neuropathic pain
8) Confidence 0.34 Published 2008 Journal Glia Section Abstract Doc Link 18240312 Disease Relevance 0.85 Pain Relevance 0.66
Microglia cultured on dishes coated with fibronectin, an extracellular matrix molecule, expressed a higher level of P2X(4)R protein when compared with those cultured on control dishes.
Positive_regulation (level) of Gene_expression (expressed) of P2X in extracellular matrix
9) Confidence 0.34 Published 2008 Journal Glia Section Abstract Doc Link 18240312 Disease Relevance 0.62 Pain Relevance 0.53
Microglial cells from lyn(-/-) mice showed a deficit in their ability to increase P2X(4)R expression in response to fibronectin, a factor implicated as a microglial P2X(4)R upregulator in allodynia.
Positive_regulation (response) of Gene_expression (expression) of P2X in Microglial cells associated with allodynia
10) Confidence 0.28 Published 2008 Journal Glia Section Abstract Doc Link 17918263 Disease Relevance 1.07 Pain Relevance 0.84
Superfusion of the P2X1-desensitizing agonist ?
Positive_regulation (Superfusion) of Gene_expression (Superfusion) of P2X1 associated with agonist
11) Confidence 0.24 Published 2008 Journal The Journal of Physiology Section Body Doc Link PMC2655397 Disease Relevance 0 Pain Relevance 0.24
These activated microglia upregulate expression of P2X/Y receptors (e.g., P2X4 and P2Y12).
Positive_regulation (upregulate) of Gene_expression (expression) of P2X in microglia
12) Confidence 0.20 Published 2010 Journal Brain Res Rev Section Abstract Doc Link 19931560 Disease Relevance 0.75 Pain Relevance 0.66
Nevertheless, the release of another inhibitory transmitter, glycine, is augmented by P2X receptor activation in the dorsal horn [161] and in the brainstem trigeminal nucleus [162].
Positive_regulation (augmented) of Gene_expression (activation) of P2X receptor in brainstem associated with medulla and dorsal horn
13) Confidence 0.11 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072919 Disease Relevance 0.08 Pain Relevance 0.56

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