INT114017

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Context Info
Confidence 0.75
First Reported 2003
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 2.38
Pain Relevance 0.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CD200)
Anatomy Link Frequency
embryos 1
fibroblasts 1
ovary 1
CD200 (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 6 91.84 High High
antagonist 2 89.20 High High
postherpetic neuralgia 20 74.64 Quite High
agonist 1 55.36 Quite High
Pain 35 50.12 Quite High
Shingles 9 50.00 Quite Low
imagery 27 46.56 Quite Low
Neuropeptide 2 25.00 Low Low
depression 5 5.00 Very Low Very Low Very Low
corticosteroid 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Herpes Zoster 159 99.36 Very High Very High Very High
Helminth Infection 69 91.12 High High
Disease 39 90.20 High High
Stroke 86 80.40 Quite High
Unconsciousness 2 78.60 Quite High
Melanoma 73 76.08 Quite High
Post Operative Pain 20 74.64 Quite High
Emergencies 4 61.00 Quite High
Infection 8 59.32 Quite High
Injury 1 57.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In Chinese hamster ovary cells expressing human OX1/OX2 receptors OX A- and B-evoked increases in intracellular Ca2+ were measured with and without barbiturates.
Gene_expression (expressing) of OX2 in ovary
1) Confidence 0.75 Published 2003 Journal Neuroscience Section Abstract Doc Link 14580935 Disease Relevance 0 Pain Relevance 0.59
A meeting with twenty-nine consultant radiotherapists took place on 21 January 1961 in the Council Room of the Royal College of Surgeons in London.37 The chairman told those present that “considerable difficulty had been encountered in making plans which would not only be ethically acceptable and feasible but which, at the same time, could produce information of value.”38 In preliminary consultations, the draft protocol had found little support; the purpose of this meeting, therefore, was “to find out whether the radiotherapists concerned were in agreement about the importance of the principle of controlled clinical trials and whether further agreement could be reached upon a subject worth trying and upon the methods involved.”39 Windeyer added that the MRC committee that appointed the various working parties “had felt that there was not enough controlled work at present and that not all of the claims which were being made for various forms of treatment could stand up to rigorous examination.”40 Would the radiotherapists provide the Working Party with clearer directions?


Gene_expression (committee) of MRC
2) Confidence 0.54 Published 2007 Journal Bull Hist Med Section Body Doc Link PMC2635845 Disease Relevance 0 Pain Relevance 0
MITF transcript levels did not correlate with CD200 expression in NZM cell lines (Figure S3), whereas MLANA, a transcriptional target of MITF, strongly correlated with MITF expression as expected (Figure S3).
Gene_expression (expression) of CD200
3) Confidence 0.53 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794539 Disease Relevance 0.20 Pain Relevance 0
Arthur Landsborough Thomson, a leading member of the MRC executive, made it clear in private correspondence that the Council had no wish to meddle with “low-level” research “consisting mainly in the observation of cases and the trial of methods, that they [clinicians] can take in their stride while treating patients”.19 He did, however, indicate that the Council expected to extend its domain to the overall direction of British medical research, and to do so without pandering to the whims of individual institutions and clinicians, no matter how powerful and well endowed.20
Gene_expression (executive) of MRC
4) Confidence 0.41 Published 2008 Journal Medical History Section Body Doc Link PMC2570450 Disease Relevance 0.06 Pain Relevance 0
Two sets of opaque, numbered envelopes will be prepared for each site (one each for MRC score 1 and MRC scores 2–3) containing cards indicating the allocated group.
Gene_expression (scores) of MRC
5) Confidence 0.12 Published 2008 Journal BMC Neurol Section Body Doc Link PMC2329664 Disease Relevance 0.31 Pain Relevance 0
Two sets of opaque, numbered envelopes will be prepared for each site (one each for MRC score 1 and MRC scores 2–3) containing cards indicating the allocated group.
Gene_expression (score) of MRC
6) Confidence 0.12 Published 2008 Journal BMC Neurol Section Body Doc Link PMC2329664 Disease Relevance 0.31 Pain Relevance 0
The MRC and the NIMR
Gene_expression (The) of MRC
7) Confidence 0.09 Published 2008 Journal Notes and records of the Royal Society of London Section Body Doc Link PMC2628576 Disease Relevance 0.06 Pain Relevance 0
The institutional focus of this paper is the principal research lab of the MRC (created as the Medical Research Committee in 1913, becoming Council in 1920; MRC is used for both).
Gene_expression (used) of MRC
8) Confidence 0.09 Published 2008 Journal Notes and records of the Royal Society of London Section Body Doc Link PMC2628576 Disease Relevance 0 Pain Relevance 0
Merck laboratories passaged the virus further though different cell lines including HEL, GPE, WI-38, and MRC-5 human diploid fibroblasts to produce the commercial varicella vaccine (Varivax) which contains 1350 PFUs in 0.5 ml of sterile water (Ellis 1995).
Gene_expression (produce) of MRC-5 in fibroblasts associated with herpes zoster
9) Confidence 0.04 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2374947 Disease Relevance 1.32 Pain Relevance 0.29
Here, we went a step further and showed that since mitochondria are so important for C. elegans development, a mechanism, providing embryos with a substantial amount of mtDNA, evolved to ensure that enough active MRC is present during development.
Gene_expression (present) of MRC in embryos
10) Confidence 0.01 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2665216 Disease Relevance 0.14 Pain Relevance 0

General Comments

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