INT114020

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.33
First Reported 2003
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 4.24
Pain Relevance 2.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Adora1) plasma membrane (Adora1) signal transducer activity (Adora1)
Anatomy Link Frequency
Nerve 2
spinal cord dorsal horn 1
Adora1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
adenocard 39 100.00 Very High Very High Very High
agonist 14 100.00 Very High Very High Very High
Nerve growth factor 10 100.00 Very High Very High Very High
Spinal cord 4 99.52 Very High Very High Very High
intrathecal 23 99.06 Very High Very High Very High
Dorsal horn 6 99.04 Very High Very High Very High
Somatostatin 4 98.08 Very High Very High Very High
allodynia 16 95.76 Very High Very High Very High
Pain 8 95.20 Very High Very High Very High
Inflammation 10 92.84 High High
Disease Link Frequency Relevance Heat
Cancer 36 100.00 Very High Very High Very High
Necrosis 28 100.00 Very High Very High Very High
Nociception 8 99.76 Very High Very High Very High
Neuropathic Pain 22 99.00 Very High Very High Very High
Pain 5 95.20 Very High Very High Very High
Alzheimer's Dementia 16 94.84 High High
Injury 9 93.24 High High
INFLAMMATION 12 92.84 High High
Apoptosis 28 87.08 High High
Hypersensitivity 2 85.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IT injection of N6-cyclohexyladenosine (CHA), an adenosine A1 receptor agonist, also produces anti-nociception in the neuropathic rat model [5].
Gene_expression (produces) of adenosine A1 receptor associated with nociception, adenocard, neuropathic pain, agonist and intrathecal
1) Confidence 0.33 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2908226 Disease Relevance 1.08 Pain Relevance 1.33
In the present study, we investigate the distribution of the adenosine A1 receptor in the rat spinal cord dorsal horn using immunohistochemistry, in situ hybridization, radioligand binding, and confocal microscopy.
Spec (investigate) Gene_expression (distribution) of adenosine A1 receptor in spinal cord dorsal horn associated with adenocard, dorsal horn and spinal cord
2) Confidence 0.27 Published 2003 Journal Neuroscience Section Abstract Doc Link 14580941 Disease Relevance 0.19 Pain Relevance 0.75
Finally, treatment with phenelzine resulted in up-regulation of three (Glial cell line derived neurotrophic factor superfamily receptor alpha 2, Macrophage expressed gene 1, Fyn proto-oncogene), 14 (Nerve growth factor beta, Midkine, Type 1 tumor necrosis factor receptor regulator, Jun D proto-oncogene, Adenosine A1 receptor, Leptin receptor, Adrenomedullin, Arrestin beta 1, Syntaxin 1A, Epsin 1, Caspase 8, Cyclin-dependent kinase 5, Synuclein alpha, Amyloid beta precursor protein), and five (Transforming growth factor beta 2, Growth differentiation factor 15, Regucalcin, Syntaxin 11, Homogentisate 1, 2-dioxygenase) genes and down-regulation of four (Immunoglobulin superfamily member 6, Secreted phosphoprotein 1, Phospholipase A2 activating protein, Tumor necrosis factor receptor superfamily member 6), three (Serum amyloid A 4, Apoptosis facilitator Bcl-2-like protein 14, Interferon gamma), and two (Tumor necrosis factor alpha induced protein 6, Granzyme A) genes after treatment for one, three and seven days, respectively (Table 1 and 2).
Gene_expression (expressed) of Adenosine A1 receptor in Nerve associated with necrosis, adenocard, nerve growth factor, cancer, alzheimer's dementia and apoptosis
3) Confidence 0.25 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC3009642 Disease Relevance 1.61 Pain Relevance 0.25
Treatment with imipramine resulted in significant up-regulation of three (Glial cell line derived neurotrophic factor superfamily receptor alpha 2, Macrophage expressed gene 1, Tumor necrosis factor member 11), 13 (Nerve growth factor beta, tumor necrosis factor receptor regulator, Jun D proto-oncogene, Adenosine A1 receptor, Neurotrophic tyrosine kinase receptor type 2, Somatostatin receptor 5, Leptin receptor, Arrestin beta 1, Epsin 1, Caspase 8, Cyclin-dependent kinase 5, Synuclein alpha, Amyloid beta precursor protein), and five (Transforming growth factor beta 2, RAB6A member RAS oncogene family, Regucalcin, Syntaxin 11, Homogentisate 1, 2-dioxygenase) genes and down-regulation of five (Leukocyte cell derived chemotaxin 1, Phospholipase A2 activating protein, Mitogen-activated protein kinase), one (Interferon gamma), and two (Tumor necrosis factor alpha induced protein 6, Granzyme A) genes after one, three and seven days of treatment, respectively.
Gene_expression (expressed) of Adenosine A1 receptor in Nerve associated with necrosis, adenocard, nerve growth factor, cancer, alzheimer's dementia and somatostatin
4) Confidence 0.22 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC3009642 Disease Relevance 1.36 Pain Relevance 0.23

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox