INT114023

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Context Info
Confidence 0.60
First Reported 2003
Last Reported 2011
Negated 1
Speculated 1
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 5.35
Pain Relevance 8.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nos1) mitochondrion (Nos1) oxidoreductase activity (Nos1)
plasma membrane (Nos1) cytoskeleton (Nos1) nucleus (Nos1)
Anatomy Link Frequency
neuronal 4
sciatic nerve 2
spinal cord 2
Peripheral nerve 2
body 2
Nos1 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 94 100.00 Very High Very High Very High
Neuronal nitric oxide synthase 4 100.00 Very High Very High Very High
Neuropathic pain 42 99.98 Very High Very High Very High
Peripheral nerve injury 8 99.98 Very High Very High Very High
qutenza 79 99.70 Very High Very High Very High
Spinal cord 82 99.68 Very High Very High Very High
dorsal root ganglion 45 99.68 Very High Very High Very High
Kinase C 39 99.40 Very High Very High Very High
withdrawal 33 99.16 Very High Very High Very High
amygdala 126 99.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nervous System Injury 105 99.98 Very High Very High Very High
Neuropathic Pain 83 99.98 Very High Very High Very High
Ganglion Cysts 45 99.68 Very High Very High Very High
Body Weight 1 98.20 Very High Very High Very High
Hyperalgesia 23 95.16 Very High Very High Very High
Urological Neuroanatomy 18 93.76 High High
Targeted Disruption 126 93.36 High High
Drug Dependence 1 91.68 High High
Pain 25 91.64 High High
Inflammatory Pain 6 90.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, it has been reported that the MEK1 pathway is involved in upregulation of nNOS transcription under some circumstances [75].
Positive_regulation (upregulation) of Transcription (transcription) of nNOS
1) Confidence 0.60 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2680977 Disease Relevance 0.46 Pain Relevance 0.03
Our data showed that peripheral neuropathic pain increases the transcription and expression of NOS1 in the spinal cord of WT mice, indicating that NOS1 might be the main responsible for the maintenance of peripheral neuropathic pain after the total sciatic nerve ligation.
Positive_regulation (increases) of Transcription (transcription) of NOS1 in sciatic nerve associated with neuropathic pain, sciatic nerve and spinal cord
2) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001461 Disease Relevance 1.17 Pain Relevance 1.04
The results obtained were as follows: (1) Sinomenine restored the decrease in body weight and alleviated the signs of morphine-withdrawal in mice. (2) Sinomenine also reduced the increases in nNOS mRNA expression and nNOS activity resulting from morphine-dependence, and simultaneously attenuated the high level of NO in both tissues following morphine-withdrawal. (3) Administration of sinomenine alone did not develop physical dependence in mice.
Positive_regulation (increases) of Transcription (expression) of nNOS in body associated with addiction, body weight, physical dependence, withdrawal and morphine
3) Confidence 0.47 Published 2007 Journal Sheng Li Xue Bao Section Abstract Doc Link 17579782 Disease Relevance 0.58 Pain Relevance 1.33
Our results revealed that the mRNA expression of inducible nitric oxide synthase (iNOS) was reduced by approximately 50% in GEB-pretreated mice versus the controls, whereas the mRNA expression levels of endothelial nitric oxide synthase (eNOS) and neuronal nitric oxide synthase (nNOS) remained unchanged.
Neg (unchanged) Positive_regulation (unchanged) of Transcription (levels) of neuronal nitric oxide synthase in neuronal associated with neuronal nitric oxide synthase
4) Confidence 0.46 Published 2007 Journal Int. J. Mol. Med. Section Abstract Doc Link 17611639 Disease Relevance 0.46 Pain Relevance 0.14
Peripheral nerve injury increased expression of both mRNA and protein for nNOS in the DRG, but not in spinal cord [19-22].
Positive_regulation (increased) of Transcription (expression) of nNOS in Peripheral nerve associated with dorsal root ganglion, nervous system injury, spinal cord and peripheral nerve injury
5) Confidence 0.43 Published 2007 Journal Mol Pain Section Body Doc Link PMC2089056 Disease Relevance 1.83 Pain Relevance 1.31
Our final experiments analyzed increases in expression of mRNA for nitric oxide synthase type 1, N-methyl-D-aspartate (NMDA) receptor NMDAR1 subunit and prodynorphin in spinal cord tissue.
Spec (analyzed) Positive_regulation (increases) of Spec (analyzed) Transcription (expression) of nitric oxide synthase type 1 in spinal cord associated with spinal cord
6) Confidence 0.36 Published 2003 Journal Neuroscience Section Abstract Doc Link 14580950 Disease Relevance 0.75 Pain Relevance 1.76
Akt activation was observed a few minutes after morphine administration and was rapidly transmitted to the nNOS.
Positive_regulation (activation) of Transcription (transmitted) of nNOS associated with morphine
7) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0.09 Pain Relevance 0.99
For the medial amygdala it has been shown that capsaicin significantly increases the expression of neuronal NOS (nNOS) mRNA and protein, as demonstrated by in-situ hybridization and immunohistochemistry [43].
Positive_regulation (increases) of Transcription (expression) of nNOS in neuronal associated with qutenza and amygdala
8) Confidence 0.23 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020947 Disease Relevance 0 Pain Relevance 1.47

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