INT114025

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Context Info
Confidence 0.70
First Reported 2003
Last Reported 2011
Negated 0
Speculated 1
Reported most in Abstract
Documents 20
Total Number 21
Disease Relevance 16.48
Pain Relevance 15.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nos1) mitochondrion (Nos1) oxidoreductase activity (Nos1)
plasma membrane (Nos1) cytoskeleton (Nos1) nucleus (Nos1)
Anatomy Link Frequency
neuronal 5
spinal cord 4
sciatic nerve 2
dorsal root ganglia 2
striatum 1
Nos1 (Mus musculus)
Pain Link Frequency Relevance Heat
Sciatic nerve 388 100.00 Very High Very High Very High
Spinal cord 294 100.00 Very High Very High Very High
Neuronal nitric oxide synthase 8 100.00 Very High Very High Very High
Peripheral nerve injury 8 99.78 Very High Very High Very High
allodynia 184 99.76 Very High Very High Very High
Neuropathic pain 130 99.70 Very High Very High Very High
dorsal root ganglion 45 99.68 Very High Very High Very High
Hippocampus 51 99.46 Very High Very High Very High
qutenza 79 99.42 Very High Very High Very High
Morphine 94 99.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 518 100.00 Very High Very High Very High
Nervous System Injury 233 99.78 Very High Very High Very High
Neuropathic Pain 325 99.76 Very High Very High Very High
Ganglion Cysts 45 99.68 Very High Very High Very High
Body Weight 8 97.94 Very High Very High Very High
Aging 25 96.40 Very High Very High Very High
Drug Induced Neurotoxicity 3 95.28 Very High Very High Very High
Hyperalgesia 91 94.68 High High
Drug Dependence 1 91.68 High High
Pain 56 91.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results revealed that the mRNA expression of inducible nitric oxide synthase (iNOS) was reduced by approximately 50% in GEB-pretreated mice versus the controls, whereas the mRNA expression levels of endothelial nitric oxide synthase (eNOS) and neuronal nitric oxide synthase (nNOS) remained unchanged.
Transcription (levels) of neuronal nitric oxide synthase in neuronal associated with neuronal nitric oxide synthase
1) Confidence 0.70 Published 2007 Journal Int. J. Mol. Med. Section Abstract Doc Link 17611639 Disease Relevance 0.46 Pain Relevance 0.14
Our results revealed that the mRNA expression of inducible nitric oxide synthase (iNOS) was reduced by approximately 50% in GEB-pretreated mice versus the controls, whereas the mRNA expression levels of endothelial nitric oxide synthase (eNOS) and neuronal nitric oxide synthase (nNOS) remained unchanged.
Transcription (expression) of nNOS in neuronal associated with neuronal nitric oxide synthase
2) Confidence 0.70 Published 2007 Journal Int. J. Mol. Med. Section Abstract Doc Link 17611639 Disease Relevance 0.46 Pain Relevance 0.14
Therefore, our subsequent aim is to evaluate the mRNA and protein expression of NOS1 and NOS2 isoenzymes in the spinal cord of WT mice at 21 days after sciatic nerve ligation and correlate it with their corresponding behavior responses.
Transcription (expression) of NOS1 in spinal cord associated with sciatic nerve and spinal cord
3) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001461 Disease Relevance 1.14 Pain Relevance 0.92
In the striatum and nucleus accumbens, expression of PPT mRNA was elevated but PPE-A mRNA, D-1, D-2 receptor, and nNOS mRNA were not changed in hph-1 mice compared to controls.
Transcription (changed) of nNOS in nucleus accumbens associated with nucleus accumbens
4) Confidence 0.67 Published 2004 Journal Exp. Neurol. Section Abstract Doc Link 15530890 Disease Relevance 0.32 Pain Relevance 0.54
The mRNA and protein levels of NOS1, NOS2 and NOS3 in the spinal cord of WT and KO mice, at 21 days after surgery, were also assessed.
Transcription (levels) of NOS1 in spinal cord associated with targeted disruption and spinal cord
5) Confidence 0.65 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC3001461 Disease Relevance 1.79 Pain Relevance 1.00
Our data showed that peripheral neuropathic pain increases the transcription and expression of NOS1 in the spinal cord of WT mice, indicating that NOS1 might be the main responsible for the maintenance of peripheral neuropathic pain after the total sciatic nerve ligation.
Transcription (transcription) of NOS1 in sciatic nerve associated with neuropathic pain, sciatic nerve and spinal cord
6) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001461 Disease Relevance 1.16 Pain Relevance 1.03
Furthermore, it has been reported that the MEK1 pathway is involved in upregulation of nNOS transcription under some circumstances [75].
Transcription (transcription) of nNOS
7) Confidence 0.62 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2680977 Disease Relevance 0.46 Pain Relevance 0.03
Peripheral nerve injury increased expression of both mRNA and protein for nNOS in the DRG, but not in spinal cord [19-22].
Transcription (expression) of nNOS in Peripheral nerve associated with dorsal root ganglion, nervous system injury, spinal cord and peripheral nerve injury
8) Confidence 0.59 Published 2007 Journal Mol Pain Section Body Doc Link PMC2089056 Disease Relevance 1.83 Pain Relevance 1.30
The relative mRNA levels of NOS3 gene in the spinal cord from sham-operated and sciatic nerve-injured WT, NOS2-KO and NOS1-KO mice are shown in Fig. 4A.
Transcription (levels) of NOS1 in spinal cord associated with targeted disruption, sciatic nerve and spinal cord
9) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001461 Disease Relevance 1.10 Pain Relevance 0.58
The results obtained were as follows: (1) Sinomenine restored the decrease in body weight and alleviated the signs of morphine-withdrawal in mice. (2) Sinomenine also reduced the increases in nNOS mRNA expression and nNOS activity resulting from morphine-dependence, and simultaneously attenuated the high level of NO in both tissues following morphine-withdrawal. (3) Administration of sinomenine alone did not develop physical dependence in mice.
Transcription (expression) of nNOS in body associated with addiction, body weight, physical dependence, withdrawal and morphine
10) Confidence 0.53 Published 2007 Journal Sheng Li Xue Bao Section Abstract Doc Link 17579782 Disease Relevance 0.58 Pain Relevance 1.33
The expression level of NOS1 mRNA in the dorsal root ganglia was similar between mice with and without postherpetic allodynia.
Transcription (expression) of NOS1 in dorsal root ganglia associated with allodynia
11) Confidence 0.53 Published 2007 Journal Neuroscience Section Abstract Doc Link 17997045 Disease Relevance 1.68 Pain Relevance 1.27
The expression level of NOS1 mRNA in the dorsal root ganglia was similar between mice with and without postherpetic allodynia.
Transcription (level) of NOS1 in dorsal root ganglia associated with allodynia
12) Confidence 0.53 Published 2007 Journal Neuroscience Section Abstract Doc Link 17997045 Disease Relevance 1.67 Pain Relevance 1.27
Our results revealed that the mRNA expression of inducible nitric oxide synthase (iNOS) was reduced by approximately 50% in GEB-pretreated mice versus the controls, whereas the mRNA expression levels of endothelial nitric oxide synthase (eNOS) and neuronal nitric oxide synthase (nNOS) remained unchanged.
Transcription (expression) of neuronal nitric oxide synthase in neuronal associated with neuronal nitric oxide synthase
13) Confidence 0.52 Published 2007 Journal Int. J. Mol. Med. Section Abstract Doc Link 17611639 Disease Relevance 0.46 Pain Relevance 0.14
Our results revealed that the mRNA expression of inducible nitric oxide synthase (iNOS) was reduced by approximately 50% in GEB-pretreated mice versus the controls, whereas the mRNA expression levels of endothelial nitric oxide synthase (eNOS) and neuronal nitric oxide synthase (nNOS) remained unchanged.
Transcription (levels) of nNOS in neuronal associated with neuronal nitric oxide synthase
14) Confidence 0.52 Published 2007 Journal Int. J. Mol. Med. Section Abstract Doc Link 17611639 Disease Relevance 0.46 Pain Relevance 0.14
The relative mRNA levels of NOS1 gene in the spinal cord from sham-operated and sciatic nerve-injured WT and NOS2-KO mice are shown in Fig. 2A.
Transcription (levels) of NOS1 gene in sciatic nerve associated with targeted disruption, sciatic nerve and spinal cord
15) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001461 Disease Relevance 1.13 Pain Relevance 0.71
In this sense, it has been reported that: 1- different regions behave differently during aging and/or degeneration [16]; 2- nNOS expression and synthesis can be regulated by Ca2+fluxes independently from nNOS activity especially in the hippocampus [24]; (c) there is a post-transcriptional regulation of nNOS expression in the brain of SAM [17].
Transcription (transcriptional) of nNOS in hippocampus associated with aging and hippocampus
16) Confidence 0.45 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1766358 Disease Relevance 0.32 Pain Relevance 0.25
Akt activation was observed a few minutes after morphine administration and was rapidly transmitted to the nNOS.
Transcription (transmitted) of nNOS associated with morphine
17) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0.09 Pain Relevance 0.91
Our final experiments analyzed increases in expression of mRNA for nitric oxide synthase type 1, N-methyl-D-aspartate (NMDA) receptor NMDAR1 subunit and prodynorphin in spinal cord tissue.
Spec (analyzed) Transcription (expression) of nitric oxide synthase type 1 in spinal cord associated with spinal cord
18) Confidence 0.37 Published 2003 Journal Neuroscience Section Abstract Doc Link 14580950 Disease Relevance 0.74 Pain Relevance 1.75
For the medial amygdala it has been shown that capsaicin significantly increases the expression of neuronal NOS (nNOS) mRNA and protein, as demonstrated by in-situ hybridization and immunohistochemistry [43].
Transcription (expression) of nNOS in neuronal associated with qutenza and amygdala
19) Confidence 0.32 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020947 Disease Relevance 0 Pain Relevance 1.46
On the contrary, no differences in NOS-1 or NOS-3 mRNA levels were found between infected and control mice.
Transcription (levels) of NOS-1
20) Confidence 0.28 Published 2007 Journal Neurochem Res Section Abstract Doc Link PMC2295255 Disease Relevance 0.32 Pain Relevance 0.17

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