INT114026

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.67
First Reported 2003
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 3.13
Pain Relevance 2.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Grin1) plasma membrane (Grin1) enzyme binding (Grin1)
cytoplasm (Grin1)
Anatomy Link Frequency
P19 1
spinal cord 1
brain 1
Grin1 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 7 98.84 Very High Very High Very High
Morphine 10 96.68 Very High Very High Very High
allodynia 6 95.20 Very High Very High Very High
Hyperalgesia 3 94.64 High High
tolerance 5 91.68 High High
Thermal hyperalgesia 8 88.92 High High
Central grey 77 84.60 Quite High
midbrain 6 83.48 Quite High
antagonist 9 80.80 Quite High
nMDA receptor 71 80.24 Quite High
Disease Link Frequency Relevance Heat
Injury 17 99.72 Very High Very High Very High
Embryonal Carcinoma 6 96.88 Very High Very High Very High
Neuropathic Pain 8 95.20 Very High Very High Very High
Hyperalgesia 12 94.64 High High
Hypersensitivity 7 93.28 High High
Rheumatoid Arthritis 4 87.32 High High
Urological Neuroanatomy 77 84.60 Quite High
Repression 134 77.84 Quite High
Sprains And Strains 1 69.56 Quite High
INFLAMMATION 25 64.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our final experiments analyzed increases in expression of mRNA for nitric oxide synthase type 1, N-methyl-D-aspartate (NMDA) receptor NMDAR1 subunit and prodynorphin in spinal cord tissue.
Spec (analyzed) Transcription (expression) of NMDAR1 in spinal cord associated with spinal cord
1) Confidence 0.67 Published 2003 Journal Neuroscience Section Abstract Doc Link 14580950 Disease Relevance 0.75 Pain Relevance 1.78
In situ hybridization of NR1 mRNA
Transcription (hybridization) of NR1
2) Confidence 0.59 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797636 Disease Relevance 0.12 Pain Relevance 0
In situ hybridizations were performed using the Ventana “Discovery” platform (Ventana Medical Systems, Inc.), their BlueMap detection kit and digoxigenin-labeled RNA probes transcribed in vitro from a rat NR1 cDNA plasmid, pSP-ASP (Iwasato et al., 1997), which should recognize all splice variants of NR1.
Transcription (transcribed) of NR1
3) Confidence 0.55 Published 2007 Journal Frontiers in Integrative Neuroscience Section Body Doc Link PMC2526007 Disease Relevance 0 Pain Relevance 0
NMDAR mRNA in situ hybridization
Transcription (mRNA) of NMDAR
4) Confidence 0.55 Published 2007 Journal Frontiers in Integrative Neuroscience Section Body Doc Link PMC2526007 Disease Relevance 0 Pain Relevance 0.03
Complementary RNA (cRNA), derived from the AvrII-SphI 0.4-kb antisense DNA fragment of rat NR1 cDNA containing from exon 13 to exon 16, was labeled with DIG (Roche) and used as the probe for detecting NMDAR1 mRNA in mouse brain.
Transcription (detecting) of NMDAR1 in brain
5) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797636 Disease Relevance 0.18 Pain Relevance 0.07
Enhanced NMDAR-mediated synaptic transmission after injury
Transcription (transmission) of NMDAR-mediated associated with injury
6) Confidence 0.42 Published 2009 Journal Mol Pain Section Body Doc Link PMC2803476 Disease Relevance 0.93 Pain Relevance 0.58
end of NMDAR1 transcript results in four possible different NMDAR1 isoforms.
Transcription (transcript) of NMDAR1
7) Confidence 0.33 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1790950 Disease Relevance 0.58 Pain Relevance 0
All four NR1 mRNA isoforms were detected in differentiated P19 cells, with 26% of E21 inclusion in the NR1–1/NR1–2 isoform pair (Exon 22a; Figure 1B, lane 1) and 12% inclusion in the NR1–3/NR1–4 isoform pair (Exon 22b; Figure S1A).
Transcription (detected) of NR1 in P19
8) Confidence 0.22 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1790950 Disease Relevance 0.58 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox