INT11403

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Context Info
Confidence 0.14
First Reported 1990
Last Reported 2007
Negated 1
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 6.21
Pain Relevance 0.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
Reiter 1
egg 1
Arigg4 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 3 89.92 High High
fibrosis 6 85.88 High High
abdominal pain 1 83.32 Quite High
Arthritis 96 77.04 Quite High
Clonidine 6 74.80 Quite High
spinal inflammation 4 31.04 Quite Low
rheumatoid arthritis 12 29.64 Quite Low
Inflammation 12 20.08 Low Low
Disease Link Frequency Relevance Heat
Infection 7 99.78 Very High Very High Very High
Autoimmune Disease 9 99.70 Very High Very High Very High
Nephritis 1 99.68 Very High Very High Very High
Pancreatitis 8 99.40 Very High Very High Very High
Syndrome 4 98.66 Very High Very High Very High
Hemorrhage 3 90.80 High High
Pain 3 89.92 High High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

3 89.68 High High
Renal Disease 3 88.96 High High
Disease 8 87.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Systemic administration of glucocorticoid successfully induced remission of pancreatitis and nephritis along with the reduction of IgG4.
Negative_regulation (reduction) of IgG4 associated with nephritis and pancreatitis
1) Confidence 0.14 Published 2007 Journal Lupus Section Abstract Doc Link 17402370 Disease Relevance 1.69 Pain Relevance 0.08
A progressive significant decrease in the level of circulating anti-SWAP IgG1 after treatment, a decrease of IgG4 three months after treatment and a decrease in the egg count after therapy.
Negative_regulation (decrease) of IgG4 in egg
2) Confidence 0.02 Published 2002 Journal J Egypt Soc Parasitol Section Abstract Doc Link 12512825 Disease Relevance 0.51 Pain Relevance 0.15
Anti-SWAP IgG1 and IgG4 is useful means in diagnosis and cure, as well as significant reduction of anti-SWAP IgG1 and IgG4 after treatment.
Negative_regulation (reduction) of IgG4
3) Confidence 0.02 Published 2002 Journal J Egypt Soc Parasitol Section Abstract Doc Link 12512825 Disease Relevance 0.43 Pain Relevance 0.13
No significant difference in IgGI or IgG4 in patients having GIT manifestation and organomegalic patients and/or asymptomatic patient.
Neg (No) Negative_regulation (difference) of IgG4
4) Confidence 0.02 Published 2002 Journal J Egypt Soc Parasitol Section Abstract Doc Link 12512825 Disease Relevance 0.54 Pain Relevance 0.16
Both clearances and fractional clearances of IgG4 and IgG decreased after captopril in groups 1 and 2.2+ The decrease in IgG4 clearance was correlated to that of renal vascular resistances in group 1 patients.
Negative_regulation (decrease) of IgG4
5) Confidence 0.01 Published 1992 Journal Am. J. Physiol. Section Abstract Doc Link 1558156 Disease Relevance 0.67 Pain Relevance 0.13
In an examination of the IgG isotypes active in human Reiter's syndrome, they appeared to be predominantly of the T-helper-2-like isotype IgG4, equivalent to IgG1 in K/BxN mice [15].
Negative_regulation (equivalent) of IgG4 in Reiter associated with syndrome
6) Confidence 0.01 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297579 Disease Relevance 0.52 Pain Relevance 0.17
A significant decrease in the anionic-cationic immunoglobulin ratio (IgG4/IgG) was observed in groups 1, 2, and 3.
Negative_regulation (decrease) of IgG4
7) Confidence 0.01 Published 1992 Journal Am. J. Physiol. Section Abstract Doc Link 1558156 Disease Relevance 0.63 Pain Relevance 0.07
Association of autoimmunity with IgG2 and IgG4 subclass deficiency in a growth hormone-deficient child.
Negative_regulation (deficiency) of IgG4 associated with autoimmune disease
8) Confidence 0.00 Published 1990 Journal J. Clin. Immunol. Section Title Doc Link 2084146 Disease Relevance 0.56 Pain Relevance 0.06
We describe a 7-year-old male with severe autoimmune disease, recurrent infections, a marked deficiency of IgG2 and IgG4, and an inability to respond to polysaccharide antigens.
Negative_regulation (deficiency) of IgG4 associated with autoimmune disease and infection
9) Confidence 0.00 Published 1990 Journal J. Clin. Immunol. Section Abstract Doc Link 2084146 Disease Relevance 0.43 Pain Relevance 0

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