INT114058

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Context Info
Confidence 0.31
First Reported 2003
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 13
Total Number 15
Disease Relevance 9.23
Pain Relevance 4.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Insr) endosome (Insr) plasma membrane (Insr)
nucleus (Insr) kinase activity (Insr)
Anatomy Link Frequency
macrophages 4
bone marrow 2
Insr (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 226 100.00 Very High Very High Very High
cINOD 35 100.00 Very High Very High Very High
chemokine 28 99.60 Very High Very High Very High
cytokine 82 99.00 Very High Very High Very High
Inflammation 240 88.92 High High
tolerance 49 81.28 Quite High
Inflammatory response 22 76.36 Quite High
alcohol 12 50.00 Quite Low
COX-2 inhibitor 5 49.68 Quite Low
cOX1 5 25.00 Low Low
Disease Link Frequency Relevance Heat
Obesity 932 100.00 Very High Very High Very High
Apoptosis 134 100.00 Very High Very High Very High
Cancer 144 99.12 Very High Very High Very High
Dna Damage 10 97.08 Very High Very High Very High
Insulin Resistance 245 96.04 Very High Very High Very High
INFLAMMATION 274 88.92 High High
Hyperinsulinism 33 87.32 High High
Impaired Glucose Tolerance 32 81.28 Quite High
Colon Cancer 15 75.24 Quite High
Coronary Heart Disease 4 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This analysis revealed a significant decrease in basal hepatic glucose production in IR?
Negative_regulation (decrease) of Gene_expression (production) of IR
1) Confidence 0.31 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 0.60 Pain Relevance 0.10
Insulin receptor–deficient macrophages exhibit increased susceptibility to lipid-induced apoptosis and reduced expression of matrix metalloproteinase 9
Negative_regulation (reduced) of Gene_expression (expression) of Insulin receptor in macrophages associated with metalloproteinase and apoptosis
2) Confidence 0.26 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 1.24 Pain Relevance 0.23
Treatment with both celecoxib and an ACE inhibitor/ARB decreased IGF-IR expression levels in inoculated tumor cells.
Negative_regulation (decreased) of Gene_expression (expression) of IGF-IR associated with cancer
3) Confidence 0.25 Published 2003 Journal Cancer Res. Section Abstract Doc Link 14583467 Disease Relevance 0.62 Pain Relevance 0.49
In in vitro studies, NSAIDs reduced IGF-IR expression in a dose-dependent manner in all three cell lines.
Negative_regulation (reduced) of Gene_expression (expression) of IGF-IR associated with cinod
4) Confidence 0.25 Published 2003 Journal Cancer Res. Section Abstract Doc Link 14583467 Disease Relevance 0.59 Pain Relevance 0.55
PGE(2) or angiotensin II treatment reversed the NSAID-induced down-regulation of IGF-IR expression, growth, and invasion.
Negative_regulation (reversed) of Gene_expression (expression) of IGF-IR associated with cinod
5) Confidence 0.25 Published 2003 Journal Cancer Res. Section Abstract Doc Link 14583467 Disease Relevance 0.44 Pain Relevance 0.55
PGE(2) and angiotensin II induced Akt phosphorylation, and LY294002 or wortmannin inhibited PGE(2)- or angiotensin II-induced IGF-IR expression, indicating that PGE(2) and angiotensin II both regulate IGF-IR expression by the same Akt/phosphatidylinositol-3 pathway.
Negative_regulation (inhibited) of Gene_expression (expression) of IGF-IR
6) Confidence 0.25 Published 2003 Journal Cancer Res. Section Abstract Doc Link 14583467 Disease Relevance 0.35 Pain Relevance 0.53
To verify the in vivo relevance of this cell-autonomous impairment in MMP-9 expression and activation, we first determined serum MMP-9 concentrations in lean and obese control and IR?
Negative_regulation (impairment) of Spec (determined) Gene_expression (concentrations) of IR associated with obesity and metalloproteinase
7) Confidence 0.23 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 0.46 Pain Relevance 0.57
Another question is why reduced macrophage accumulation in obese IR?
Negative_regulation (reduced) of Gene_expression (obese) of IR in macrophage associated with obesity
8) Confidence 0.23 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 1.26 Pain Relevance 0.04
To verify the in vivo relevance of this cell-autonomous impairment in MMP-9 expression and activation, we first determined serum MMP-9 concentrations in lean and obese control and IR?
Negative_regulation (determined) of Spec (determined) Gene_expression (concentrations) of IR associated with obesity and metalloproteinase
9) Confidence 0.23 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 0.41 Pain Relevance 0.56
While HFD induced a highly significant increase of circulating MMP-9 in control animals, this increase was less profound in IR?
Negative_regulation (less) of Gene_expression (profound) of IR associated with metalloproteinase
10) Confidence 0.23 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 0.43 Pain Relevance 0.56
This decrease appeared to represent reduced macrophage recruitment, since bone marrow-derived macrophages (BMDM) of IR?
Negative_regulation (derived) of Gene_expression (macrophages) of IR in bone marrow
11) Confidence 0.23 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 1.19 Pain Relevance 0.13
PGE(2) or angiotensin II treatment reversed the NSAID-induced down-regulation of IGF-IR expression, growth, and invasion.
Negative_regulation (regulation) of Gene_expression (expression) of IGF-IR associated with cinod
12) Confidence 0.19 Published 2003 Journal Cancer Res. Section Abstract Doc Link 14583467 Disease Relevance 0.43 Pain Relevance 0.55
Consistent with the OGTT data, acute ethanol treatment significantly downregulated the insulin postreceptor signaling molecule PPAR-?
Negative_regulation (downregulated) of Gene_expression (molecule) of insulin postreceptor
13) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0.08 Pain Relevance 0.04
Previously, we showed that stable knockdown of STAT1 in IR-resistant and IFN?
Negative_regulation (knockdown) of Gene_expression (resistant) of IR
14) Confidence 0.16 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.86 Pain Relevance 0
However, the microarray results indicate that the downstream insulin receptor, as well as expression of endothelial NO synthase (eNos) was suppressed by the HF diet, what agree with the recent knowledge [34].
Negative_regulation (suppressed) of Gene_expression (expression) of insulin receptor
15) Confidence 0.08 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2674043 Disease Relevance 0.29 Pain Relevance 0.07

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