INT114059

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Context Info
Confidence 0.46
First Reported 2002
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 3.49
Pain Relevance 1.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Insr) endosome (Insr) plasma membrane (Insr)
nucleus (Insr) kinase activity (Insr)
Anatomy Link Frequency
fat 1
colon 1
Insr (Mus musculus)
Pain Link Frequency Relevance Heat
gABA 28 100.00 Very High Very High Very High
tolerance 41 99.90 Very High Very High Very High
cINOD 7 99.60 Very High Very High Very High
metalloproteinase 96 97.60 Very High Very High Very High
antagonist 19 95.56 Very High Very High Very High
Opioid 23 95.28 Very High Very High Very High
Dorsal horn 5 92.36 High High
Inflammation 104 92.08 High High
Spinal cord 48 84.88 Quite High
cytokine 33 77.80 Quite High
Disease Link Frequency Relevance Heat
Obesity 386 100.00 Very High Very High Very High
Impaired Glucose Tolerance 29 99.90 Very High Very High Very High
Colon Cancer 3 96.80 Very High Very High Very High
Diabetes Mellitus 107 96.68 Very High Very High Very High
Glioma 13 93.68 High High
INFLAMMATION 117 92.08 High High
Insulin Resistance 106 87.04 High High
Cytomegalovirus Infection 5 81.92 Quite High
Cancer 17 74.08 Quite High
Disorder Of Lipid Metabolism 14 74.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Western blot analysis was performed as previously described [26] with antibodies raised against insulin receptor ?
Localization (raised) of insulin receptor
1) Confidence 0.46 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 0 Pain Relevance 0.08
Furthermore, we assessed gelatinolytic activity in WAT lysates of obese control- and IR?
Localization (lysates) of IR associated with obesity
2) Confidence 0.40 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 0.44 Pain Relevance 0.52
Moreover, while high fat feeding significantly reduced the portion of high molecular weight (HMW) adiponectin of total serum adiponectin in control animals, this diet-induced reduction was not observed in IR?
Neg (not) Localization (observed) of IR in fat
3) Confidence 0.40 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 0.94 Pain Relevance 0.16
Thus, combination therapy with NSAIDs and ACE inhibitors targeting IGF-IR might be a novel and potentially promising strategy for the chemoprevention of colon cancer.
Localization (targeting) of IGF-IR in colon associated with colon cancer and cinod
4) Confidence 0.33 Published 2003 Journal Cancer Res. Section Abstract Doc Link 14583467 Disease Relevance 0.30 Pain Relevance 0.39
The sequences of the primers used for the amplification of insulin receptor (IR), cardiac troponin T (cTNT) and GAPDH RNAs are: IR (forward 5?
Localization (amplification) of IR
5) Confidence 0.27 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597774 Disease Relevance 0.15 Pain Relevance 0
Primary outcome indexes include: oral glucose tolerance test; insulin releasing test; glycosylated hemoglobin (HA1c).
Localization (releasing) of insulin associated with tolerance and impaired glucose tolerance
6) Confidence 0.21 Published 2010 Journal Trials Section Abstract Doc Link PMC2842259 Disease Relevance 0.76 Pain Relevance 0.12
Potential of endogenously expressed insulin receptors (IR) and PDGFR to act as surrogate protein scaffolds during ERK activation by ?
Localization (act) of IR
7) Confidence 0.12 Published 2002 Journal BMC Pharmacol Section Body Doc Link PMC88976 Disease Relevance 0.24 Pain Relevance 0.32
We therefore assessed glucose tolerance and insulin secretion in adult bIGF1RKO+/?
Localization (secretion) of insulin associated with tolerance and impaired glucose tolerance
8) Confidence 0.08 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2573928 Disease Relevance 0.44 Pain Relevance 0.05
The insulin secretion (HOMA-B) and resistance index of homeostatic model assessment (HOMA-IR) were calculated according to fasting glucose and insulin level using the HOMA2 calculator (http://www.dtu.ox.ac.uk/homa).


Localization (secretion) of HOMA-IR
9) Confidence 0.05 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2551631 Disease Relevance 0.22 Pain Relevance 0
These investigators also observed the colocalization of GABA and glycine IR in a third of all glycine positive cells, with the glycinergic system maturing a day after the GABA system (Allain et al., 2006; Sibilla and Ballerini, 2008).
Localization (colocalization) of glycine IR associated with gaba
10) Confidence 0.01 Published 2010 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2866564 Disease Relevance 0 Pain Relevance 0.22

General Comments

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