INT11406

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Context Info
Confidence 0.70
First Reported 1987
Last Reported 2010
Negated 3
Speculated 3
Reported most in Abstract
Documents 49
Total Number 52
Disease Relevance 20.64
Pain Relevance 42.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CALCA) aging (CALCA) extracellular region (CALCA)
nucleus (CALCA) intracellular (CALCA) cell-cell signaling (CALCA)
Anatomy Link Frequency
sensory nerves 12
dorsal horn 6
right atrium 4
muscle 4
neuronal 4
CALCA (Homo sapiens)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 692 100.00 Very High Very High Very High
qutenza 255 100.00 Very High Very High Very High
substance P 114 100.00 Very High Very High Very High
Inflammation 101 100.00 Very High Very High Very High
Neuropeptide 80 100.00 Very High Very High Very High
Spinal cord 56 100.00 Very High Very High Very High
calcitonin gene related peptide 35 100.00 Very High Very High Very High
Neurotransmitter 11 100.00 Very High Very High Very High
Clonidine 18 99.98 Very High Very High Very High
Glutamate 4 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 53 100.00 Very High Very High Very High
Neurogenic Inflammation 13 100.00 Very High Very High Very High
Infection 38 99.98 Very High Very High Very High
Temporomandibular Joint Syndrome 1 99.96 Very High Very High Very High
Pain 169 99.90 Very High Very High Very High
Nociception 25 99.90 Very High Very High Very High
Depression 11 99.80 Very High Very High Very High
Gallstones 5 99.76 Very High Very High Very High
Heat Stress Disorders 12 99.72 Very High Very High Very High
Ganglion Cysts 57 99.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BACKGROUND: Capsaicin has been shown to exert direct vasodilating effects through increased calcitonin gene-related peptide (CGRP) release.
Positive_regulation (increased) of Localization (release) of calcitonin gene-related peptide associated with qutenza and calcitonin gene-related peptide
1) Confidence 0.70 Published 2004 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 15475832 Disease Relevance 0.07 Pain Relevance 0.26
In superfusion experiments with slices from the rat spinal cord, a release of CGRP-LI was induced by 60 mM K+ and 3 microM capsaicin in a calcium-dependent manner.
Positive_regulation (induced) of Localization (release) of CGRP in spinal cord associated with qutenza, calcitonin gene-related peptide and spinal cord
2) Confidence 0.70 Published 1987 Journal Peptides Section Abstract Doc Link 2438668 Disease Relevance 0 Pain Relevance 1.16
In gallbladders with gallstones, capsaicin-induced CGRP release was 74 +/- 16 pg per gram of muscle per 2 min (20% of normal, P < 0.001).
Positive_regulation (induced) of Localization (release) of CGRP in muscle associated with qutenza, gallstones and calcitonin gene-related peptide
3) Confidence 0.69 Published 1995 Journal J. Surg. Res. Section Abstract Doc Link 7791341 Disease Relevance 0.50 Pain Relevance 0.90
In cultured HUVECs, the CGRP secretion was increased after heat stress.
Positive_regulation (increased) of Localization (secretion) of CGRP associated with heat stress disorders and calcitonin gene-related peptide
4) Confidence 0.68 Published 2007 Journal Vascul. Pharmacol. Section Abstract Doc Link 17140857 Disease Relevance 0.80 Pain Relevance 0.71
In contrast, the low level of CGRP-LI released from ventral spinal cord slices was not significantly enhanced by incubation with either potassium or capsaicin.
Neg (not) Positive_regulation (enhanced) of Localization (released) of CGRP in ventral associated with qutenza and spinal cord
5) Confidence 0.67 Published 1994 Journal Neurosci. Lett. Section Abstract Doc Link 7970210 Disease Relevance 0 Pain Relevance 0.53
Recently, the serotonin Type 1 agonists have been shown to cause a prolonged increase in intracellular Ca(2+) in trigeminal ganglia neurons and an increased phosphatase activity that can repress stimulated CGRP secretion and transcription.
Positive_regulation (stimulated) of Localization (secretion) of CGRP in neurons associated with agonist, serotonin and calcitonin gene-related peptide
6) Confidence 0.67 Published 2002 Journal Pharmacol. Ther. Section Abstract Doc Link 12191595 Disease Relevance 0.81 Pain Relevance 1.17
Finally, the ethanol-induced increase in CGRP release from guinea-pig isolated and perfused hearts and from slices of porcine coronary arteries was abolished by capsaicin-desensitization and by capsazepine.
Positive_regulation (increase) of Localization (release) of CGRP in hearts
7) Confidence 0.66 Published 2006 Journal Cardiovasc. Res. Section Body Doc Link 16579978 Disease Relevance 0.07 Pain Relevance 0
Ethanol-induced release of CGRP may contribute to the reduction in the risk of CAD associated with alcohol consumption by various mechanisms, including the increase in coronary flow and arterial dilatation.


Positive_regulation (induced) of Localization (release) of CGRP
8) Confidence 0.66 Published 2006 Journal Cardiovasc. Res. Section Body Doc Link 16579978 Disease Relevance 0.05 Pain Relevance 0
It has been hypothesized that TG neuronal cell bodies are the source of capsaicin-stimulated release of calcitonin gene-related peptide (CGRP), and hence co-localization experiments were performed.
Positive_regulation (stimulated) of Localization (release) of calcitonin gene-related peptide in neuronal associated with qutenza, trigeminal ganglion and calcitonin gene-related peptide
9) Confidence 0.66 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 12270633 Disease Relevance 0.71 Pain Relevance 1.92
Fig. 1In migraine attacks, sensory nerves, which innervate the cerebral blood vessels, are activated to antidromically release calcitonin gene-related peptide.
Positive_regulation (activated) of Localization (release) of calcitonin in sensory nerves associated with migraine and calcitonin gene-related peptide
10) Confidence 0.65 Published 2008 Journal J Headache Pain Section Body Doc Link PMC2245994 Disease Relevance 0.77 Pain Relevance 0.85
Despite the facts that CGRP may be liberated by a variety of physiological stimuli and may act as a potent vasodilator in the human vasculature, no evidence has been found in this study that CGRP release is increased as a consequence of ischemia or ischemic pain.
Positive_regulation (increased) of Localization (release) of CGRP in vasculature associated with pain, ischemia and calcitonin gene-related peptide
11) Confidence 0.61 Published 1999 Journal Scand. Cardiovasc. J. Section Abstract Doc Link 10540919 Disease Relevance 1.10 Pain Relevance 0.90
In addition, however, they suggest that nitric oxide is required for either the release of endogenous CGRP from capsaicin-sensitive nerves or its subsequent activity.
Positive_regulation (required) of Localization (release) of CGRP in nerves associated with qutenza and calcitonin gene-related peptide
12) Confidence 0.61 Published 1993 Journal Agents Actions Section Abstract Doc Link 8317313 Disease Relevance 0.09 Pain Relevance 0.73
MK-0974 produced a concentration-dependent inhibition of dermal vasodilation, generated by capsaicin-induced release of endogenous CGRP, with plasma concentrations of 127 and 994 nM required to block 50 and 90% of the blood flow increase, respectively.
Positive_regulation (induced) of Localization (release) of CGRP in plasma associated with qutenza, increased venous pressure under development and calcitonin gene-related peptide
13) Confidence 0.60 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 18039958 Disease Relevance 0.45 Pain Relevance 1.32
Although capsaicin is known to activate TRPV1, there are reports that ethanol, also via activation of TRPV1, induces the release of CGRP as well (Trevisani et al. 2002, 2004).
Positive_regulation (induces) of Localization (release) of CGRP associated with qutenza and calcitonin gene-related peptide
14) Confidence 0.60 Published 2007 Journal Naunyn Schmiedebergs Arch Pharmacol Section Body Doc Link PMC1915621 Disease Relevance 0 Pain Relevance 0.88
These results point to an autoactivation of CGRP expression and indicate that elevated release of CGRP in the trigeminal system may create a self-sustaining feedback loop [47].


Positive_regulation (elevated) of Localization (release) of CGRP associated with calcitonin gene-related peptide
15) Confidence 0.57 Published 2008 Journal J Headache Pain Section Body Doc Link PMC2245994 Disease Relevance 0.41 Pain Relevance 1.11
BACKGROUND: Capsaicin has been shown to exert direct vasodilating effects through increased calcitonin gene-related peptide (CGRP) release.
Positive_regulation (increased) of Localization (release) of CGRP associated with qutenza and calcitonin gene-related peptide
16) Confidence 0.50 Published 2004 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 15475832 Disease Relevance 0.07 Pain Relevance 0.26
Cutaneous sensory stimulation leading to facial flushing and release of calcitonin gene-related peptide.
Positive_regulation (leading) of Localization (release) of calcitonin associated with increased venous pressure under development and calcitonin gene-related peptide
17) Confidence 0.50 Published 1992 Journal Cephalalgia Section Title Doc Link 1559259 Disease Relevance 0.77 Pain Relevance 0.75
Stimulated release of calcitonin gene-related peptide from the human right atrium in patients with and without diabetes mellitus.
Positive_regulation (Stimulated) of Localization (release) of calcitonin in right atrium associated with qutenza, diabetes mellitus and calcitonin gene-related peptide
18) Confidence 0.50 Published 2006 Journal Peptides Section Title Doc Link 16996168 Disease Relevance 0.40 Pain Relevance 0.75
The aim of the present study was to examine basal and stimulated CGRP release from cardiac tissue in patients who underwent cardiopulmonary bypass surgery and to compare patients with and without known history of diabetes mellitus.
Spec (examine) Positive_regulation (stimulated) of Spec (examine) Localization (release) of CGRP associated with diabetes mellitus and calcitonin gene-related peptide
19) Confidence 0.50 Published 2006 Journal Peptides Section Abstract Doc Link 16996168 Disease Relevance 0.36 Pain Relevance 0.65
Sumatriptan and indomethacin inhibit the NO response by inhibiting trigeminal activation and calcitonin gene-related peptide (CGRP) release.
Positive_regulation (activation) of Localization (release) of CGRP associated with sumatriptan and calcitonin gene-related peptide
20) Confidence 0.50 Published 2002 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12354573 Disease Relevance 0.35 Pain Relevance 0.63

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