INT114061

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Context Info
Confidence 0.27
First Reported 2003
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 2.03
Pain Relevance 1.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Insr) endosome (Insr) plasma membrane (Insr)
nucleus (Insr) kinase activity (Insr)
Anatomy Link Frequency
macrophages 2
colon 2
Insr (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 21 100.00 Very High Very High Very High
COX-2 inhibitor 3 100.00 Very High Very High Very High
metalloproteinase 32 99.96 Very High Very High Very High
Inflammation 34 82.12 Quite High
tolerance 12 80.56 Quite High
alcohol 12 50.00 Quite Low
cOX1 3 25.00 Low Low
COX2 3 25.00 Low Low
cytokine 11 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 41 100.00 Very High Very High Very High
Cancer 23 99.80 Very High Very High Very High
Colon Cancer 9 99.04 Very High Very High Very High
Impaired Glucose Tolerance 13 80.56 Quite High
Obesity 128 67.28 Quite High
Apoptosis 17 62.40 Quite High
Coronary Heart Disease 4 50.00 Quite Low
Stress 6 37.16 Quite Low
Insulin Resistance 34 5.00 Very Low Very Low Very Low
Diabetes Mellitus 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In in vitro studies, the effects of nonsteroidal anti-inflammatory drugs (NSAIDs) on IGF-IR expression were analyzed in three colon cancer cell lines (Colon 26, HCA-7, and LS174T).
Regulation (effects) of Gene_expression (expression) of IGF-IR in colon associated with inflammation, colon cancer and cinod
1) Confidence 0.27 Published 2003 Journal Cancer Res. Section Abstract Doc Link 14583467 Disease Relevance 0.74 Pain Relevance 0.32
The aim of the present study was to investigate the effects of COX-2 inhibitor and drugs blocking the biological activities of angiotensin II [angiotensin-converting enzyme (ACE) inhibitors or angiotensin II receptor blockers (ARBs)] on IGF-IR expression and tumor growth in vivo.
Spec (investigate) Regulation (effects) of Gene_expression (expression) of IGF-IR associated with cancer and cox-2 inhibitor
2) Confidence 0.27 Published 2003 Journal Cancer Res. Section Abstract Doc Link 14583467 Disease Relevance 0.60 Pain Relevance 0.24
Importantly, IR disruption in macrophages not only affected MMP-9 expression, but also translated into reduced MMP-9 activity.
Regulation (affected) of Gene_expression (disruption) of IR in macrophages associated with metalloproteinase
3) Confidence 0.24 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 0.34 Pain Relevance 0.50
Consistent with the OGTT data, acute ethanol treatment significantly downregulated the insulin postreceptor signaling molecule PPAR-?
Regulation (signaling) of Gene_expression (molecule) of insulin postreceptor
4) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0.08 Pain Relevance 0.04
PGE(2) and angiotensin II induced Akt phosphorylation, and LY294002 or wortmannin inhibited PGE(2)- or angiotensin II-induced IGF-IR expression, indicating that PGE(2) and angiotensin II both regulate IGF-IR expression by the same Akt/phosphatidylinositol-3 pathway.
Regulation (regulate) of Gene_expression (expression) of IGF-IR
5) Confidence 0.12 Published 2003 Journal Cancer Res. Section Abstract Doc Link 14583467 Disease Relevance 0.28 Pain Relevance 0.46

General Comments

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