INT114068

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Context Info
Confidence 0.15
First Reported 2003
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.95
Pain Relevance 0.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Agtr2, Insr) endosome (Insr) signal transducer activity (Agtr2)
cytosol (Insr) signal transduction (Agtr2) nucleus (Insr)
Agtr2 (Mus musculus)
Insr (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 14 93.60 High High
COX-2 inhibitor 2 88.24 High High
COX2 2 25.00 Low Low
cOX1 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Cancer 14 99.70 Very High Very High Very High
INFLAMMATION 2 82.80 Quite High
Colon Cancer 6 82.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We also investigated the effects of PGE(2), a major COX-2 product, in cancer cells and the effects of angiotensin II on IGF-IR expression and the underlying mechanism of action.
angiotensin II Regulation (effects) of Gene_expression (expression) of IGF-IR associated with cancer
1) Confidence 0.15 Published 2003 Journal Cancer Res. Section Abstract Doc Link 14583467 Disease Relevance 0.62 Pain Relevance 0.27
PGE(2) and angiotensin II induced Akt phosphorylation, and LY294002 or wortmannin inhibited PGE(2)- or angiotensin II-induced IGF-IR expression, indicating that PGE(2) and angiotensin II both regulate IGF-IR expression by the same Akt/phosphatidylinositol-3 pathway.
angiotensin II Regulation (regulate) of Gene_expression (expression) of IGF-IR
2) Confidence 0.07 Published 2003 Journal Cancer Res. Section Abstract Doc Link 14583467 Disease Relevance 0.33 Pain Relevance 0.51

General Comments

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