INT114070

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Context Info
Confidence 0.13
First Reported 2003
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.34
Pain Relevance 0.52

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plasma membrane (Agtr2, Insr) endosome (Insr) signal transducer activity (Agtr2)
cytosol (Insr) signal transduction (Agtr2) nucleus (Insr)
Agtr2 (Mus musculus)
Insr (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 7 93.12 High High
COX-2 inhibitor 1 30.44 Quite Low
COX2 1 25.00 Low Low
cOX1 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Cancer 7 82.92 Quite High
Colon Cancer 3 56.00 Quite High
INFLAMMATION 1 53.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PGE(2) and angiotensin II induced Akt phosphorylation, and LY294002 or wortmannin inhibited PGE(2)- or angiotensin II-induced IGF-IR expression, indicating that PGE(2) and angiotensin II both regulate IGF-IR expression by the same Akt/phosphatidylinositol-3 pathway.
angiotensin II-induced Positive_regulation (induced) of Gene_expression (expression) of IGF-IR
1) Confidence 0.13 Published 2003 Journal Cancer Res. Section Abstract Doc Link 14583467 Disease Relevance 0.34 Pain Relevance 0.52

General Comments

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