INT114080

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Context Info
Confidence 0.38
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.53
Pain Relevance 1.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (ABAT)
Anatomy Link Frequency
boutons 2
ABAT (Homo sapiens)
Pain Link Frequency Relevance Heat
gABA 58 100.00 Very High Very High Very High
Neurotransmitter 5 99.88 Very High Very High Very High
Dopamine 8 99.84 Very High Very High Very High
Glutamate 4 99.48 Very High Very High Very High
cocaine 89 92.40 High High
GABAergic 72 90.32 High High
addiction 27 87.08 High High
depression 1 80.40 Quite High
Hippocampus 1 78.52 Quite High
Glutamate receptor 1 74.24 Quite High
Disease Link Frequency Relevance Heat
Aging 17 99.44 Very High Very High Very High
Recurrence 14 91.96 High High
Epilepsy 6 87.12 High High
Amphetamine Dependence 3 87.08 High High
Depression 1 80.40 Quite High
Convulsion 4 76.68 Quite High
Scotoma 2 72.88 Quite High
Brain Injury 1 36.00 Quite Low
Cataract 1 19.44 Low Low
Sleep Disorders 6 16.48 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Factors that augment activity in this pathway include modest increases in [K+]o; loss of GABA inhibition; short-term, frequency-dependent facilitation (frequencies of 1-2 Hz); feedback activation of kainate autoreceptors; and release of zinc from recurrent mossy fiber boutons.
Negative_regulation (loss) of Negative_regulation (inhibition) of GABA in boutons associated with gaba
1) Confidence 0.38 Published 2003 Journal Neurochem. Res. Section Abstract Doc Link 14584819 Disease Relevance 0.54 Pain Relevance 0.30
In addition to increasing cerebral levels of GABA and facilitating GABA neurotransmission (Kuzniecky et al., 1998), topiramate weakens the action of glutamate, a neurotransmitter that opposes GABA’s potentially therapeutic reduction of dopamine activity.
Negative_regulation (opposes) of Negative_regulation (reduction) of GABA associated with dopamine, neurotransmitter, glutamate and gaba
2) Confidence 0.37 Published 2008 Journal Addiction Science & Clinical Practice Section Body Doc Link PMC2797110 Disease Relevance 0.47 Pain Relevance 0.86
For example, the perception of a moving stimulus in the context of a moving surround is particularly affected in aging (Betts et al., 2005) and a loss of GABA inhibition has been suggested as the mechanism underlying this perceptual loss.
Negative_regulation (loss) of Negative_regulation (inhibition) of GABA associated with gaba and aging
3) Confidence 0.11 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2893712 Disease Relevance 0.53 Pain Relevance 0.30

General Comments

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