INT114091

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Context Info
Confidence 0.48
First Reported 2004
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 4.16
Pain Relevance 1.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (Aip) cytosol (Aip) nucleolus (Aip)
plasma membrane (Aip) nucleus (Aip) cytoplasm (Aip)
Aip (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 4 98.92 Very High Very High Very High
c fibre 3 98.66 Very High Very High Very High
long-term potentiation 18 98.44 Very High Very High Very High
Hippocampus 1 93.00 High High
imagery 29 87.68 High High
corticosteroid 26 80.52 Quite High
Hyperalgesia 1 80.40 Quite High
spinal dorsal horn 2 79.12 Quite High
Inflammation 7 73.48 Quite High
amygdala 2 50.32 Quite High
Disease Link Frequency Relevance Heat
Pancreatitis 141 100.00 Very High Very High Very High
Multiple Endocrine Neoplasia Type 1 22 98.24 Very High Very High Very High
Hodgkin's Disease 16 95.92 Very High Very High Very High
Adrenal Cancer 20 95.16 Very High Very High Very High
Acromegaly 16 93.76 High High
Pituitary Cancer 72 93.48 High High
Carney Complex 10 87.44 High High
Syndrome 10 87.12 High High
Multiple Endocrine Neoplasia 4 84.40 Quite High
Congenital Anomalies 3 83.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, we observed decreased AIP mRNA and protein expression in the adrenocortical tissue when compared to normal controls (Figure 3C and 3D).
Negative_regulation (decreased) of AIP
1) Confidence 0.48 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2862671 Disease Relevance 0.82 Pain Relevance 0.03
Because MEN1 and p53 mutations had been previously excluded in this case,16,25 we hypothesized that loss of the AIP gene could be implicated.


Negative_regulation (loss) of AIP gene associated with multiple endocrine neoplasia type 1
2) Confidence 0.48 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2862671 Disease Relevance 1.64 Pain Relevance 0
In this study, the roles of these three protein kinases in the induction and maintenance of LTP of C-fiber-evoked field potentials were evaluated by application of specific inhibitors of CaMKII (KN-93 and AIP), PKA (Rp-CPT-cAMPS), and PKC (chelerythrine and Gö 6983) at the recording segments before and after LTP induction in urethane-anesthetized Sprague-Dawley rats.
Negative_regulation (inhibitors) of AIP associated with c fibre, kinase c and long-term potentiation
3) Confidence 0.41 Published 2004 Journal J. Neurophysiol. Section Abstract Doc Link 14586032 Disease Relevance 0.08 Pain Relevance 1.09
Diagnostic criteria for AIP were first developed by the JPS in 2002 and were revised in 2006 after reevaluating additional patients with AIP and with likely AIP.
Negative_regulation (revised) of AIP associated with pancreatitis
4) Confidence 0.08 Published 2011 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC3022838 Disease Relevance 1.27 Pain Relevance 0.18
RESULTS: IgM and IgA were decreased in patients with untreated AIP.
Negative_regulation (decreased) of AIP
5) Confidence 0.04 Published 2009 Journal J. Gastroenterol. Section Body Doc Link 19626266 Disease Relevance 0.17 Pain Relevance 0
CONCLUSIONS: Our results demonstrated that GU was more prevalent in AIP compared with nonautoimmune CP.
Negative_regulation (prevalent) of AIP
6) Confidence 0.03 Published 2009 Journal Pancreas Section Body Doc Link 19276869 Disease Relevance 0.19 Pain Relevance 0

General Comments

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