INT114134

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Context Info
Confidence 0.24
First Reported 2004
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.48
Pain Relevance 2.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprm1) extracellular region (Penk) plasma membrane (Oprm1)
signal transducer activity (Oprm1)
Anatomy Link Frequency
DRG 1
Penk (Rattus norvegicus)
Oprm1 (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 18 100.00 Very High Very High Very High
analgesia 56 99.58 Very High Very High Very High
agonist 20 99.34 Very High Very High Very High
Inflammation 71 98.58 Very High Very High Very High
antagonist 11 97.62 Very High Very High Very High
opioid receptor 95 97.38 Very High Very High Very High
Spinal cord 18 97.36 Very High Very High Very High
Endogenous opioid 37 96.60 Very High Very High Very High
antinociception 37 91.60 High High
IPN 7 75.00 Quite High
Disease Link Frequency Relevance Heat
Stress 18 99.24 Very High Very High Very High
INFLAMMATION 76 98.58 Very High Very High Very High
Nociception 9 84.80 Quite High
Inflammatory Pain 7 75.00 Quite High
Arthritis 2 64.72 Quite High
Pain 37 51.88 Quite High
Adhesions 13 5.00 Very Low Very Low Very Low
Ganglion Cysts 12 5.00 Very Low Very Low Very Low
Infection 6 5.00 Very Low Very Low Very Low
Disease 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The full-agonist [D-Ala(2),N-MePhe(4),Gly(5)-ol]-enkephalin (DAMGO) induced MOP receptor G protein coupling with decreasing efficacies (E(max)) from HT > SC > DRG.
enkephalin Positive_regulation (induced) of MOP receptor in DRG associated with agonist, enkephalin and spinal cord
1) Confidence 0.24 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14593084 Disease Relevance 0.61 Pain Relevance 1.05
The use of antibodies against specific endogenous opioid peptides and selective opioid receptor antagonists reveal that at the early stages of inflammation, the peripheral component of CWS-evoked analgesia is mediated by END, ENK, and DYN, which activate MOR, DOR, and KOR (Machelska et al 2003).
ENK Positive_regulation (activate) of MOR associated with stress, inflammation, antagonist, endogenous opioid, enkephalin, opioid receptor and analgesia
2) Confidence 0.03 Published 2005 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661636 Disease Relevance 0.87 Pain Relevance 1.63

General Comments

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