INT114136

Context Info Confidence 0.47 First Reported 2004 Last Reported 2010 Negated 0 Speculated 1 Reported most in Abstract Documents 3 Total Number 5 Disease Relevance 2.02 Pain Relevance 0.97

transport (Vdac1) mitochondrion (Vdac1) plasma membrane (Vdac1) protein complex (Vdac1) transmembrane transport (Vdac1)

Anatomy Link Frequency neuronal 1 pore 1 Vdac1 (Mus musculus)

Pain Link Frequency Relevance Heat gABA 18 99.24 anesthesia 12 97.36 Inflammatory response 26 60.48 Inflammation 66 28.28 addiction 3 5.00 fluoxetine 2 5.00 isoflurane 2 5.00 cva 2 5.00

Disease Link Frequency Relevance Heat Death 91 99.00 Apoptosis 51 98.70 Targeted Disruption 5 92.56 Influenza Virus Infection 52 90.24 Sprains And Strains 148 86.76 Disease 21 77.48 Stress 3 68.80 Infection 38 62.36 INFLAMMATION 84 60.08 Neurodegenerative Disease 5 57.40

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

These data indicate that neuroactive steroid binding to VDAC-1, -2, or -3 is unlikely to mediate GABA(A) receptor modulation or anesthesia.

VDAC-1 Binding (binding) of associated with anesthesia and gaba

1) Confidence 0.47 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14593090 Disease Relevance 0 Pain Relevance 0.55

Antisera to VDAC-1 were shown to coimmunoprecipitate GABA(A) receptors, suggesting a functional relationship between steroid binding to VDAC-1 and modulation of GABA(A) receptor function.

VDAC-1 Binding (binding) of associated with gaba

2) Confidence 0.35 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14593090 Disease Relevance 0 Pain Relevance 0.38

It has been suggested that PB1-F2 is able to induce cell death by disrupting mitochondrial organization through interaction with inner mitochondrial membrane adenine nucleotide translocator 3 (ANT3) and the outer mitochondrial membrane voltage channel 1 (VDAC1) to produce a mitochondrial permeability transition [12].

VDAC1 Binding (interaction) of associated with death

3) Confidence 0.16 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2908617 Disease Relevance 1.00 Pain Relevance 0

Since its discovery the consensus has been that the PB1-F2 proteins from selected viruses are pro-apoptotic, targeting the mitochondria and inducing pore formation through association with VDAC1 and ANT3 [4], [11], [12], [19], [24].

VDAC1 Binding (association) of in pore associated with apoptosis

4) Confidence 0.16 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2908617 Disease Relevance 0.71 Pain Relevance 0.03

Our study suggests a link between transcriptional dysfunction and cell death in trinucleotide repeat mediated neuronal dysfunction through voltage dependent anion channel, Vdac1, which has been recently recognized as a critical determinant of cell death.

Vdac1 Spec (determinant) Binding (recognized) of in neuronal associated with death

5) Confidence 0.05 Published 2007 Journal PLoS ONE Section Abstract Doc Link PMC2064964 Disease Relevance 0.31 Pain Relevance 0

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