INT114162

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Context Info
Confidence 0.60
First Reported 2003
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 2.22
Pain Relevance 4.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

kinase activity (Srms)
Anatomy Link Frequency
lung 2
Srms (Mus musculus)
Pain Link Frequency Relevance Heat
Opioid 83 100.00 Very High Very High Very High
Morphine 82 100.00 Very High Very High Very High
Cancer pain 3 100.00 Very High Very High Very High
transdermal 19 99.80 Very High Very High Very High
backache 26 98.98 Very High Very High Very High
Pain 103 97.60 Very High Very High Very High
analgesia 4 91.36 High High
Chronic low back pain 4 87.36 High High
depression 3 77.76 Quite High
alcohol 2 61.36 Quite High
Disease Link Frequency Relevance Heat
Cancer Pain 3 100.00 Very High Very High Very High
Low Back Pain 30 98.98 Very High Very High Very High
Cancer 2 98.20 Very High Very High Very High
Pain 101 97.60 Very High Very High Very High
Lung Cancer 4 94.00 High High
Respiratory Failure 3 74.88 Quite High
Disease 2 69.12 Quite High
Renal Disease 2 68.40 Quite High
Drug Dependence 2 60.48 Quite High
Neuropathic Pain 12 49.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
OBJECTIVE: This randomised, multicentre, direct open comparative trial evaluated the efficacy, treatment convenience, tolerability and safety aspects of transdermal therapeutic system (TTS)-fentanyl and sustained-release oral morphine (SRM) in both opioid-naïve patients with moderate-to-severe cancer-related pain and in patients who had already been using opioids for mild-to-moderate pain.
Localization (release) of SRM associated with pain, transdermal, cancer, opioid and morphine
1) Confidence 0.60 Published 2003 Journal Curr Med Res Opin Section Abstract Doc Link 14594516 Disease Relevance 0.37 Pain Relevance 0.80
MATERIAL-METHODS: According to three step analgesic guidelines recommended by the World Health Organization, 50 chronic lung cancer patients requiring third line therapy were enrolled and received either TDF patch (Grup F, n=25) or SRM per orally (Grup M, n=25) for 15 days.
Localization (received) of SRM in lung
2) Confidence 0.58 Published 2008 Journal Agri Section Body Doc Link 19085178 Disease Relevance 0.16 Pain Relevance 0
AIM: The aim of this randomized and controlled trial was to evaluate the analgesic efficacy of trans-dermal fentanyl (TDF) and sustained-release oral morphine (SRM) primarily and their side effects secondarily, in patients with chronic lung cancer-related pain.
Localization (release) of SRM in lung
3) Confidence 0.55 Published 2008 Journal Agri Section Body Doc Link 19085178 Disease Relevance 0.19 Pain Relevance 0
It included 680 patients with long-standing low back pain who were randomized to treatment with either slow-release morphine (SRM) or transdermal fentanyl (TDF) for 13 months.
Localization (release) of SRM associated with low back pain, transdermal, morphine and backache
4) Confidence 0.03 Published 2007 Journal BMC Med Section Body Doc Link PMC2242794 Disease Relevance 0.63 Pain Relevance 1.47
We assessed data from a large-scale randomized comparison of transdermal fentanyl (TDF) and sustained-release oral morphine (slow-release morphine; SRM) to determine characteristics of treatment responders.


Localization (release) of SRM associated with transdermal and morphine
5) Confidence 0.03 Published 2007 Journal BMC Med Section Abstract Doc Link PMC2242794 Disease Relevance 0.52 Pain Relevance 1.15
PURPOSE: To evaluate effectiveness and safety information of transdermal fentanyl (TDF) (Duragesic/Durogesic) and sustained-release oral morphine (SRM) in cancer pain (CP) and chronic non-cancer pain (NCP), a pooled analysis was conducted on datasets of published, open label, uncontrolled (no comparator group) and randomised controlled (with SRM as comparator) studies of TDF.
Localization (release) of SRM associated with transdermal, cancer pain and morphine
6) Confidence 0.03 Published 2004 Journal Curr Med Res Opin Section Abstract Doc Link 15383190 Disease Relevance 0.35 Pain Relevance 0.73

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