INT114163

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Context Info
Confidence 0.27
First Reported 2003
Last Reported 2009
Negated 2
Speculated 1
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0.20
Pain Relevance 1.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (HTR5A) plasma membrane (HTR5A) signal transducer activity (HTR5A)
Anatomy Link Frequency
platelet 2
HTR5A (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 4 98.44 Very High Very High Very High
Serotonin 9 94.80 High High
sSRI 10 93.24 High High
fluoxetine 6 89.76 High High
agonist 7 88.36 High High
Sumatriptan 1 76.40 Quite High
depression 4 75.48 Quite High
Potency 1 57.84 Quite High
monoamine 1 38.84 Quite Low
Disease Link Frequency Relevance Heat
Post-partum Depression 2 75.48 Quite High
Depression 2 62.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These concerns have led our group to examine whether exposure through breast milk has a discernible effect on platelet 5-HT uptake.
Spec (whether) Regulation (effect) of platelet 5-HT in platelet
1) Confidence 0.27 Published 2003 Journal Pediatrics Section Abstract Doc Link 14595087 Disease Relevance 0.14 Pain Relevance 0.57
The response to alpha-Me-5-HT was unaffected by the 5-HT(2B) and 5-HT(2C) receptor antagonists, SB204741 [(N-(1-methyl-1H-indolyl-5-yl)-N-(3-methyl-5-isothiazolyl)urea)] and RS102221 [8-[5-(2,4-dimethoxy-5-(4-trifluoromethyl phenylsulphonamido)phenyl-5-oxopentyl]-1,3,8-triazaspiro[4.5]decane-2,4-dione].
Neg (unaffected) Regulation (unaffected) of alpha-Me-5-HT associated with antagonist
2) Confidence 0.24 Published 2009 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 19075042 Disease Relevance 0 Pain Relevance 0.47
We found that infants who were exposed to sertraline through their mothers' breast milk experienced little to no change in platelet 5-HT levels, suggestive of minimal effects on peripheral and central 5-HT transporter blockade.
Neg (no) Regulation (change) of platelet 5-HT in platelet
3) Confidence 0.23 Published 2003 Journal Pediatrics Section Abstract Doc Link 14595087 Disease Relevance 0.06 Pain Relevance 0.58

General Comments

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