INT114171

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Context Info
Confidence 0.49
First Reported 2003
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 11
Total Number 13
Disease Relevance 5.75
Pain Relevance 8.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Grip2) plasma membrane (Grip2) cytoskeleton (Grip2)
cytoplasm (Grip2)
Anatomy Link Frequency
medulla 2
spinal cord 2
hippocampus 2
plasma 1
prefrontal 1
Grip2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 22 99.98 Very High Very High Very High
Inflammation 29 99.84 Very High Very High Very High
Rostral ventromedial medulla 10 99.68 Very High Very High Very High
Pain 12 99.52 Very High Very High Very High
Hippocampus 182 99.24 Very High Very High Very High
Neuropathic pain 5 99.16 Very High Very High Very High
central sensitization 2 98.60 Very High Very High Very High
Hyperalgesia 15 97.76 Very High Very High Very High
nMDA receptor antagonist 7 97.20 Very High Very High Very High
spinal dorsal horn 14 96.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 21 99.84 Very High Very High Very High
Pain 11 99.52 Very High Very High Very High
Neuropathic Pain 12 99.16 Very High Very High Very High
Stress 358 99.00 Very High Very High Very High
Hyperalgesia 19 97.76 Very High Very High Very High
Nociception 10 96.92 Very High Very High Very High
Injury 5 91.96 High High
Alzheimer's Dementia 2 81.92 Quite High
Amyloid Plaque 1 77.24 Quite High
Li-fraumeni Syndrome 24 73.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
By method of Western blot, expression of GluR1 (the main subunit of the AMPA receptor) and its phosphorylated forms at serine 845 (pGluR1-Ser845) and at serine 831 (pGluR1-Ser831) in the spinal dorsal horn was observed.
Phosphorylation (phosphorylated) of AMPA receptor in dorsal horn associated with spinal dorsal horn
1) Confidence 0.49 Published 2008 Journal Brain Res. Section Abstract Doc Link 18289517 Disease Relevance 0.75 Pain Relevance 0.86
The present study aims to investigate changes of spinal cord AMPA receptor GluR1 and its phosphorylation in inflammatory and neuropathic pain.
Spec (investigate) Phosphorylation (phosphorylation) of AMPA receptor in spinal cord associated with inflammation, neuropathic pain and spinal cord
2) Confidence 0.43 Published 2008 Journal Brain Res. Section Abstract Doc Link 18289517 Disease Relevance 0.76 Pain Relevance 0.68
Changes in AMPA receptor phosphorylation in the rostral ventromedial medulla after inflammatory hyperalgesia in rats.
Phosphorylation (phosphorylation) of AMPA in medulla associated with hyperalgesia, inflammation and rostral ventromedial medulla
3) Confidence 0.29 Published 2004 Journal Neurosci. Lett. Section Title Doc Link 15276247 Disease Relevance 0.62 Pain Relevance 1.00
The current study was designed to investigate the role of the AMPA receptor subunit, GluR1, and its phosphorylated forms (at Ser-831 and Ser-845) in central sensitization in rat spinal cord.
Phosphorylation (phosphorylated) of AMPA in spinal cord associated with central sensitization and spinal cord
4) Confidence 0.27 Published 2003 Journal Neuroscience Section Abstract Doc Link 14596864 Disease Relevance 0.10 Pain Relevance 0.35
These findings provide new evidence linking in vivo AMPA receptor phosphorylation in the RVM pain modulatory circuitry to the enhanced descending pain modulation after inflammation.
Phosphorylation (phosphorylation) of AMPA in RVM associated with pain, inflammation and rostral ventromedial medulla
5) Confidence 0.25 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15276247 Disease Relevance 0.83 Pain Relevance 0.98
Phosphorylated CaMK II potentiates synaptic transmission by enhancement of AMPA receptor channel function via phosphorylation of GluR1 subunit of the receptor and the addition of AMPA receptors to synapses.
Phosphorylation (phosphorylation) of AMPA in synapses
6) Confidence 0.10 Published 2004 Journal Sheng Li Xue Bao Section Abstract Doc Link 14985835 Disease Relevance 0 Pain Relevance 0.82
Using an acute inescapable stress protocol with rats, we found opposite effects on AMPA receptor phosphorylation in the medial prefrontal cortex (mPFC) and dorsal hippocampus (DH) compared to the amygdala and ventral hippocampus (VH).
Phosphorylation (phosphorylation) of AMPA receptor in prefrontal associated with stress, hippocampus and amygdala
7) Confidence 0.05 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2999558 Disease Relevance 0.58 Pain Relevance 0.56
In contrast, while the elevated platform stress protocol causes a dramatic increase in plasma corticosterone levels, we observed a decrease in phosphorylation of AMPA receptors in the PFC, which would be expected to have the opposite effect on glutamatergic processes.
Phosphorylation (phosphorylation) of AMPA in plasma associated with stress
8) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2999558 Disease Relevance 0.64 Pain Relevance 0.23
One of its main targets is the GluR1 subunit of the AMPA receptor, which gets phosphorylated at Ser831 [40].
Phosphorylation (phosphorylated) of AMPA receptor
9) Confidence 0.03 Published 2008 Journal Mol Pain Section Body Doc Link PMC2424039 Disease Relevance 0.63 Pain Relevance 1.12
Typically, phosphorylation of the Ser831 and Ser845 sites of AMPA receptors occurs via protein kinase A (PKA) and calcium/calmodulin-dependent protein kinase II (CaMKII) or protein kinase C (PKC), respectively, and potentiates AMPA currents in the hippocampus [9,163].
Phosphorylation (phosphorylation) of AMPA in hippocampus associated with kinase c and hippocampus
10) Confidence 0.02 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2701287 Disease Relevance 0.17 Pain Relevance 0.53
Recent work has reported that tianeptine modulates the phosphorylation of AMPA receptor subunits in the hippocampus [186].
Phosphorylation (phosphorylation) of AMPA in hippocampus associated with hippocampus
11) Confidence 0.02 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2701287 Disease Relevance 0.29 Pain Relevance 0.54
Recently JNK has been reported to phosphorylate AMPA receptor subunits and affect their trafficking (15).
Phosphorylation (phosphorylate) of AMPA
12) Confidence 0.01 Published 2009 Journal Molecular & Cellular Proteomics : MCP Section Body Doc Link PMC2667352 Disease Relevance 0.38 Pain Relevance 0.19
In contrast, they enhanced the AMPA-induced CREB phosphorylation and PEnk gene expression.
Phosphorylation (phosphorylation) of AMPA-induced
13) Confidence 0.01 Published 2006 Journal Cereb. Cortex Section Abstract Doc Link 16407481 Disease Relevance 0 Pain Relevance 0.44

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