INT114172

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Context Info
Confidence 0.63
First Reported 2003
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 8
Total Number 29
Disease Relevance 15.73
Pain Relevance 14.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gria1) endoplasmic reticulum (Gria1) plasma membrane (Gria1)
protein complex (Gria1)
Anatomy Link Frequency
amygdala 12
hippocampus 12
ventral 9
dorsal 3
spinal cord 2
Gria1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
long-term potentiation 497 100.00 Very High Very High Very High
Glutamate receptor 49 100.00 Very High Very High Very High
Pain 9 100.00 Very High Very High Very High
qutenza 8 100.00 Very High Very High Very High
Rostral ventromedial medulla 5 99.76 Very High Very High Very High
amygdala 645 99.68 Very High Very High Very High
Spinal cord 32 99.52 Very High Very High Very High
antidepressant 82 99.46 Very High Very High Very High
fluoxetine 30 99.44 Very High Very High Very High
sSRI 28 99.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 1711 99.98 Very High Very High Very High
Anxiety Disorder 119 99.86 Very High Very High Very High
Urological Neuroanatomy 20 98.68 Very High Very High Very High
INFLAMMATION 31 97.32 Very High Very High Very High
Inflammatory Pain 28 94.96 High High
Depression 170 93.84 High High
Injury 2 87.88 High High
Pain 13 86.52 High High
Nociception 14 84.56 Quite High
Affective Disorder 42 84.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The upregulated GluR1 phosphorylation was blocked by pretreatment, but not by post-treatment, with the local anesthetic, lidocaine, at the site of inflammation.
Positive_regulation (upregulated) of Phosphorylation (phosphorylation) of GluR1 associated with inflammation, lidocaine and local anesthetic
1) Confidence 0.63 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15276247 Disease Relevance 0.61 Pain Relevance 0.94
Specifically, fluoxetine administration was seen to increase GluA1 phosphorylation at the Ser845-GluA1 site, whereas tianeptine treatment increased GluA1 phosphorylation at the Ser831-GluA1 site in the frontal cortex and hippocampus, as well as at the Ser845-GluA1 site in the hippocampus [16], [35].
Positive_regulation (increase) of Phosphorylation (phosphorylation) of GluA1 in hippocampus associated with urological neuroanatomy, hippocampus and fluoxetine
2) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2999558 Disease Relevance 0.80 Pain Relevance 0.49
Using similar reasoning, the increase in Ser845-GluA1 phosphorylation observed within the amygdala might explain how acute stress enhances LTP in that region [6].
Positive_regulation (increase) of Phosphorylation (phosphorylation) of GluA1 in amygdala associated with stress, long-term potentiation and amygdala
3) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2999558 Disease Relevance 0.51 Pain Relevance 0.54
Specifically, fluoxetine administration was seen to increase GluA1 phosphorylation at the Ser845-GluA1 site, whereas tianeptine treatment increased GluA1 phosphorylation at the Ser831-GluA1 site in the frontal cortex and hippocampus, as well as at the Ser845-GluA1 site in the hippocampus [16], [35].
Positive_regulation (increased) of Phosphorylation (phosphorylation) of GluA1 in hippocampus associated with urological neuroanatomy, hippocampus and fluoxetine
4) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2999558 Disease Relevance 0.87 Pain Relevance 0.49
Yet, in contrast to our results, Fumagalli and colleagues reported a stress-induced increase in GluA1 phosphorylation at the Ser831 site in the hippocampus of mice after restraint stress [42] and a similar pattern has been reported in the hippocampus of rats after acute swim stress [49].
Positive_regulation (increase) of Phosphorylation (phosphorylation) of GluA1 in hippocampus associated with stress and hippocampus
5) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2999558 Disease Relevance 0.94 Pain Relevance 0.13
Moreover, the contrasting results we obtained for the GluA1 phosphorylation in the DH and the VH, which were manifested as a decrease of Ser831-GluA1 phosphorylation and an increase of Ser845-GluA1 phosphorylation, respectively, provide support for the recent hypothesis that stress differentially regulates ventral and dorsal routing within the hippocampus [8], [25].
Positive_regulation (increase) of Phosphorylation (phosphorylation) of GluA1 in ventral associated with stress and hippocampus
6) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2999558 Disease Relevance 0.60 Pain Relevance 0.63
Therefore, tianeptine's ability to protect LTP from stress-induced disruption might be related to its capacity to augment AMPAR GluA1 phosphorylation [16], [35].
Positive_regulation (augment) of Phosphorylation (phosphorylation) of AMPAR GluA1 associated with stress and long-term potentiation
7) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2999558 Disease Relevance 0.85 Pain Relevance 0.47
Other antidepressants, such as SSRIs and tricyclics, have been shown to increase phosphorylation of the Ser845 site on the glutamate receptor subunit 1 (GluR1) of hippocampal AMPA receptors [45,187].
Positive_regulation (increase) of Phosphorylation (phosphorylation) of GluR1 associated with antidepressant, glutamate receptor and ssri
8) Confidence 0.49 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2701287 Disease Relevance 0.27 Pain Relevance 0.55
We also found a substantial, rapid increase in staining for synaptic GluR1 subunits phosphorylated on the S845 residue in the ipsilateral dorsal horn after peripheral noxious stimulation.
Positive_regulation (increase) of Phosphorylation (phosphorylated) of GluR1 in dorsal horn associated with dorsal horn
9) Confidence 0.43 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15215299 Disease Relevance 0 Pain Relevance 0.28
Protein kinase A phosphorylation of GluR1 Ser845 promotes the surface-expression of GluR1 in cultured hippocampal neurons during activity-dependent long-term potentiation [35] and might also be responsible for spinal GluR1 membrane insertion in vivo following CFA-induced inflammation.
Spec (might) Positive_regulation (responsible) of Phosphorylation (phosphorylation) of GluR1 in spinal associated with inflammation and long-term potentiation
10) Confidence 0.43 Published 2008 Journal Mol Pain Section Body Doc Link PMC2628655 Disease Relevance 0.46 Pain Relevance 0.56
Thirty minutes after the end of stress, changes in the phosphorylation sites of both GluA1 and GluA2 were found, with a decreased phosphorylation level at the Tyr876-GluA2 and Ser880-GluA2 sites in the amygdala (t (23)?
Positive_regulation (-) of Phosphorylation (phosphorylation) of GluA1 in amygdala associated with stress and amygdala
11) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2999558 Disease Relevance 0.52 Pain Relevance 0.49
Thirty minutes after the end of stress, changes in the phosphorylation sites of both GluA1 and GluA2 were found, with a decreased phosphorylation level at the Tyr876-GluA2 and Ser880-GluA2 sites in the amygdala (t (23)?
Positive_regulation (-) of Phosphorylation (phosphorylation) of GluA1 in amygdala associated with stress and amygdala
12) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2999558 Disease Relevance 0.52 Pain Relevance 0.49
Thirty minutes after the end of stress, changes in the phosphorylation sites of both GluA1 and GluA2 were found, with a decreased phosphorylation level at the Tyr876-GluA2 and Ser880-GluA2 sites in the amygdala (t (23)?
Positive_regulation (-) of Phosphorylation (phosphorylation) of GluA1 in amygdala associated with stress and amygdala
13) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2999558 Disease Relevance 0.52 Pain Relevance 0.49
Thirty minutes after the end of stress, changes in the phosphorylation sites of both GluA1 and GluA2 were found, with a decreased phosphorylation level at the Tyr876-GluA2 and Ser880-GluA2 sites in the amygdala (t (23)?
Positive_regulation (-) of Phosphorylation (phosphorylation) of GluA1 in amygdala associated with stress and amygdala
14) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2999558 Disease Relevance 0.51 Pain Relevance 0.48
Increased phosphorylation of the GluR1 subunit of spinal cord alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor in rats following intradermal injection of capsaicin.
Positive_regulation (Increased) of Phosphorylation (phosphorylation) of GluR1 in spinal cord associated with qutenza and spinal cord
15) Confidence 0.41 Published 2003 Journal Neuroscience Section Title Doc Link 14596864 Disease Relevance 0.08 Pain Relevance 0.58
Moreover, the contrasting results we obtained for the GluA1 phosphorylation in the DH and the VH, which were manifested as a decrease of Ser831-GluA1 phosphorylation and an increase of Ser845-GluA1 phosphorylation, respectively, provide support for the recent hypothesis that stress differentially regulates ventral and dorsal routing within the hippocampus [8], [25].
Positive_regulation (increase) of Phosphorylation (phosphorylation) of GluA1 in ventral associated with stress and hippocampus
16) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2999558 Disease Relevance 0.60 Pain Relevance 0.63
Moreover, the contrasting results we obtained for the GluA1 phosphorylation in the DH and the VH, which were manifested as a decrease of Ser831-GluA1 phosphorylation and an increase of Ser845-GluA1 phosphorylation, respectively, provide support for the recent hypothesis that stress differentially regulates ventral and dorsal routing within the hippocampus [8], [25].
Positive_regulation (increase) of Phosphorylation (phosphorylation) of GluA1 in ventral associated with stress and hippocampus
17) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2999558 Disease Relevance 0.60 Pain Relevance 0.63
Recent work with phosphomutant GluA1 mice, which have point mutations at both the Ser831-GluA1 and Ser845-GluA1 sites, suggests that this antidepressant-like drug effect might be related to AMPAR GluA1 subunit phosphorylation.
Positive_regulation (related) of Phosphorylation (phosphorylation) of AMPAR GluA1 associated with antidepressant
18) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2999558 Disease Relevance 0.79 Pain Relevance 0.49
Here we have reported that stress induces a decrease in Ser831-GluA1 phosphorylation.
Positive_regulation (induces) of Phosphorylation (phosphorylation) of GluA1 associated with stress
19) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2999558 Disease Relevance 0.64 Pain Relevance 0.11
In contrast to what was observed in the mPFC for Ser831-GluA1, stress increased the phosphorylation states of Ser845-GluA1 in the amygdala and VH (t (19)?
Positive_regulation (increased) of Phosphorylation (phosphorylation) of GluA1 in amygdala associated with stress, hippocampus and amygdala
20) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2999558 Disease Relevance 0.54 Pain Relevance 0.57

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