INT114173

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Context Info
Confidence 0.82
First Reported 2003
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 27
Total Number 67
Disease Relevance 33.73
Pain Relevance 31.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gria1) endoplasmic reticulum (Gria1) plasma membrane (Gria1)
protein complex (Gria1)
Anatomy Link Frequency
amygdala 8
hippocampus 5
dorsal 4
spinal cord 4
ventral 4
Gria1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate receptor 103 100.00 Very High Very High Very High
Spinal cord 76 99.98 Very High Very High Very High
Inflammation 96 99.84 Very High Very High Very High
qutenza 28 99.80 Very High Very High Very High
Pain 27 99.80 Very High Very High Very High
Hippocampus 2123 99.72 Very High Very High Very High
amygdala 1156 99.68 Very High Very High Very High
Rostral ventromedial medulla 10 99.68 Very High Very High Very High
long-term potentiation 1166 99.56 Very High Very High Very High
fluoxetine 49 99.26 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 3139 99.92 Very High Very High Very High
INFLAMMATION 84 99.84 Very High Very High Very High
Injury 18 99.72 Very High Very High Very High
Anxiety Disorder 281 99.70 Very High Very High Very High
Targeted Disruption 414 99.16 Very High Very High Very High
Neuropathic Pain 23 99.16 Very High Very High Very High
Pain 58 99.04 Very High Very High Very High
Urological Neuroanatomy 53 98.68 Very High Very High Very High
Inflammatory Pain 56 98.48 Very High Very High Very High
Cognitive Disorder 160 97.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunostaining showed that GluR1 and its phosphorylated forms were localized in the superficial laminae of dorsal horn and quantitative image analysis supported the immunoblotting results.
Phosphorylation (phosphorylated) of GluR1 in dorsal horn associated with dorsal horn
1) Confidence 0.82 Published 2003 Journal Neuroscience Section Abstract Doc Link 14596864 Disease Relevance 0.07 Pain Relevance 0.52
These results suggest that phosphorylated GluR1 (pGluR1-Ser845 and pGluR1-Ser831) might play a role in the induction of inflammatory but not neuropathic pain.
Phosphorylation (phosphorylated) of GluR1 associated with inflammation and neuropathic pain
2) Confidence 0.81 Published 2008 Journal Brain Res. Section Abstract Doc Link 18289517 Disease Relevance 0.84 Pain Relevance 0.82
Widespread expression of the AMPA receptor GluR2 subunit at glutamatergic synapses in the rat spinal cord and phosphorylation of GluR1 in response to noxious stimulation revealed with an antigen-unmasking method.
Phosphorylation (phosphorylation) of GluR1 in spinal cord associated with qutenza and spinal cord
3) Confidence 0.81 Published 2004 Journal J. Neurosci. Section Title Doc Link 15215299 Disease Relevance 0 Pain Relevance 0.40
These results suggest that phosphorylated GluR1 (pGluR1-Ser845 and pGluR1-Ser831) might play a role in the induction of inflammatory but not neuropathic pain.
Phosphorylation (phosphorylated) of GluR1 associated with inflammation and neuropathic pain
4) Confidence 0.80 Published 2008 Journal Brain Res. Section Abstract Doc Link 18289517 Disease Relevance 0.84 Pain Relevance 0.82
For the analysis of the western blotting data, the levels of GluA phosphorylated subunits were normalized to total GluA levels, based on a previous method [16].
Phosphorylation (phosphorylated) of GluA
5) Confidence 0.80 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2999558 Disease Relevance 0.16 Pain Relevance 0.04
First, since PKA and CaMKII act in parallel in controlling synaptic incorporation of GluR1 [39], reduced phosphorylation of GluR1p845 may affect activity-dependent AMPA receptor trafficking.
Phosphorylation (phosphorylation) of GluR1
6) Confidence 0.80 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2169299 Disease Relevance 0.93 Pain Relevance 0.59
Recently, it has been reported that phosphorylation of GluR1p845 in the neostriatum was reduced in neurabin KO mice [20].
Phosphorylation (phosphorylation) of GluR1 associated with targeted disruption
7) Confidence 0.80 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2169299 Disease Relevance 0.55 Pain Relevance 0.06
For instance, PP1 could inhibit CaMKII function [15], [33], thereby affecting the phosphorylation on GluR1p831.
Phosphorylation (phosphorylation) of GluR1
8) Confidence 0.80 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2169299 Disease Relevance 0.56 Pain Relevance 0.06
Other antidepressants, such as SSRIs and tricyclics, have been shown to increase phosphorylation of the Ser845 site on the glutamate receptor subunit 1 (GluR1) of hippocampal AMPA receptors [45,187].
Phosphorylation (phosphorylation) of GluR1 associated with antidepressant, glutamate receptor and ssri
9) Confidence 0.79 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2701287 Disease Relevance 0.27 Pain Relevance 0.55
The upregulated GluR1 phosphorylation was blocked by pretreatment, but not by post-treatment, with the local anesthetic, lidocaine, at the site of inflammation.
Phosphorylation (phosphorylation) of GluR1 associated with inflammation, lidocaine and local anesthetic
10) Confidence 0.74 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15276247 Disease Relevance 0.61 Pain Relevance 0.94
We also found a substantial, rapid increase in staining for synaptic GluR1 subunits phosphorylated on the S845 residue in the ipsilateral dorsal horn after peripheral noxious stimulation.
Phosphorylation (phosphorylated) of GluR1 in dorsal horn associated with dorsal horn
11) Confidence 0.71 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15215299 Disease Relevance 0 Pain Relevance 0.28
Protein kinase A phosphorylation of GluR1 Ser845 promotes the surface-expression of GluR1 in cultured hippocampal neurons during activity-dependent long-term potentiation [35] and might also be responsible for spinal GluR1 membrane insertion in vivo following CFA-induced inflammation.
Phosphorylation (phosphorylation) of GluR1 in spinal associated with inflammation and long-term potentiation
12) Confidence 0.70 Published 2008 Journal Mol Pain Section Body Doc Link PMC2628655 Disease Relevance 0.39 Pain Relevance 0.49
Specifically, fluoxetine administration was seen to increase GluA1 phosphorylation at the Ser845-GluA1 site, whereas tianeptine treatment increased GluA1 phosphorylation at the Ser831-GluA1 site in the frontal cortex and hippocampus, as well as at the Ser845-GluA1 site in the hippocampus [16], [35].
Phosphorylation (phosphorylation) of GluA1 in hippocampus associated with urological neuroanatomy, hippocampus and fluoxetine
13) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2999558 Disease Relevance 0.86 Pain Relevance 0.49
We have previously reported that elevated platform stress does not lead to a general modulation of GluA1 phosphorylation in brain tissue sampled from the entire frontal cortices [35].
Phosphorylation (phosphorylation) of GluA1 in brain associated with stress
14) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2999558 Disease Relevance 0.67 Pain Relevance 0.07
Using similar reasoning, the increase in Ser845-GluA1 phosphorylation observed within the amygdala might explain how acute stress enhances LTP in that region [6].
Phosphorylation (phosphorylation) of GluA1 in amygdala associated with stress, long-term potentiation and amygdala
15) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2999558 Disease Relevance 0.51 Pain Relevance 0.54
Yet, in contrast to our results, Fumagalli and colleagues reported a stress-induced increase in GluA1 phosphorylation at the Ser831 site in the hippocampus of mice after restraint stress [42] and a similar pattern has been reported in the hippocampus of rats after acute swim stress [49].
Phosphorylation (phosphorylation) of GluA1 in hippocampus associated with stress and hippocampus
16) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2999558 Disease Relevance 0.89 Pain Relevance 0.13
Namely, these effects occur because acute stress differentially modulates GluA1 AMPAR subunit phosphorylation, with decreased phosphorylation seen in the DH and mPFC and increased phosphorylation seen in the amygdala.
Phosphorylation (phosphorylation) of GluA1 in amygdala associated with stress, hippocampus and amygdala
17) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2999558 Disease Relevance 0.51 Pain Relevance 0.59
Thirty minutes after the end of stress, changes in the phosphorylation sites of both GluA1 and GluA2 were found, with a decreased phosphorylation level at the Tyr876-GluA2 and Ser880-GluA2 sites in the amygdala (t (23)?
Phosphorylation (phosphorylation) of GluA1 in amygdala associated with stress and amygdala
18) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2999558 Disease Relevance 0.46 Pain Relevance 0.48
Specifically, fluoxetine administration was seen to increase GluA1 phosphorylation at the Ser845-GluA1 site, whereas tianeptine treatment increased GluA1 phosphorylation at the Ser831-GluA1 site in the frontal cortex and hippocampus, as well as at the Ser845-GluA1 site in the hippocampus [16], [35].
Phosphorylation (phosphorylation) of GluA1 in hippocampus associated with urological neuroanatomy, hippocampus and fluoxetine
19) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2999558 Disease Relevance 0.80 Pain Relevance 0.49
Moreover, the contrasting results we obtained for the GluA1 phosphorylation in the DH and the VH, which were manifested as a decrease of Ser831-GluA1 phosphorylation and an increase of Ser845-GluA1 phosphorylation, respectively, provide support for the recent hypothesis that stress differentially regulates ventral and dorsal routing within the hippocampus [8], [25].
Phosphorylation (phosphorylation) of GluA1 in ventral associated with stress and hippocampus
20) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2999558 Disease Relevance 0.55 Pain Relevance 0.58

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