INT114176

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Context Info
Confidence 0.20
First Reported 2003
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.50
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SOS1) signal transduction (SOS1) intracellular (SOS1)
DNA binding (SOS1)
Anatomy Link Frequency
endometrium 1
HGF 1
SOS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kappa opioid receptor 8 99.92 Very High Very High Very High
endometriosis 108 96.80 Very High Very High Very High
cytokine 2 96.72 Very High Very High Very High
Inflammation 4 96.32 Very High Very High Very High
agonist 2 95.60 Very High Very High Very High
pulpitis 1 92.24 High High
opioid receptor 1 41.12 Quite Low
Opioid 1 36.48 Quite Low
pain pelvic 2 5.00 Very Low Very Low Very Low
Dismenorea 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Periodontitis 1 99.84 Very High Very High Very High
Disease 11 99.20 Very High Very High Very High
Endometriosis 138 96.80 Very High Very High Very High
INFLAMMATION 3 96.32 Very High Very High Very High
Pulpitis 1 92.24 High High
Wound Healing 1 90.88 High High
Adhesions 2 81.16 Quite High
Acute Liver Failure 1 71.52 Quite High
Ovarian Cancer 15 5.00 Very Low Very Low Very Low
Reprotox - General 3 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These studies demonstrate that the activation of JNK by kappa-opioid receptors is routed via Gbetagamma, Src, FAK, Sos, Rac, and Cdc42.
Positive_regulation (routed) of Sos associated with kappa opioid receptor
1) Confidence 0.20 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14996948 Disease Relevance 0.16 Pain Relevance 0.27
Furthermore, upregulation of SOS has been demonstrated in eutopic endometrium of late-secretory phase with deep endometriosis [17].
Positive_regulation (upregulation) of SOS in endometrium associated with endometriosis
2) Confidence 0.02 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2615013 Disease Relevance 0.82 Pain Relevance 0.36
Consequently, concentrations of HGF in gingival crevicular fluid (GCF) increase in periodontitis.
Positive_regulation (increase) of gingival crevicular fluid in HGF associated with periodontitis
3) Confidence 0.00 Published 2003 Journal Arch. Oral Biol. Section Abstract Doc Link 14596869 Disease Relevance 0.53 Pain Relevance 0.23

General Comments

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