INT11418

Context Info Confidence 0.14 First Reported 1992 Last Reported 2008 Negated 0 Speculated 0 Reported most in Abstract Documents 5 Total Number 6 Disease Relevance 1.82 Pain Relevance 1.50

cytosol (Cbr1) oxidoreductase activity (Cbr1) plasma membrane (Cbr1) nucleus (Cbr1) cytoplasm (Cbr1)

Cbr1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat qutenza 16 98.14 c fibre 8 78.80 Pain 4 10.00 Analgesic 2 10.00 palliative 2 5.00

Disease Link Frequency Relevance Heat Pressure Volume 2 Under Development 4 99.64 Heart Rate Under Development 4 99.30 Sleep Disorders 4 99.04 Increased Venous Pressure Under Development 8 95.52 Biliary Cancer 4 76.84 Cancer 2 50.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Results after atropine indicated that the immediate increases in Vbr and Cbr were mainly cholinergic.

Positive_regulation (increases) of Cbr

1) Confidence 0.14 Published 1992 Journal J. Appl. Physiol. Section Abstract Doc Link 1559957 Disease Relevance 0.40 Pain Relevance 0.34

Vagal cooling (0 degrees C) prevented the pulmonary chemoreflex; it also abolished the immediate increases in Vbr and Cbr in four of six sheep and substantially reduced them in two sheep; it did not affect the late increases in Vbr and Pa.

Positive_regulation (increases) of Cbr

2) Confidence 0.14 Published 1992 Journal J. Appl. Physiol. Section Abstract Doc Link 1559957 Disease Relevance 0.41 Pain Relevance 0.36

Right atrial injection of capsaicin evoked a prompt pulmonary chemoreflex (apnea, bradycardia, and hypotension), with immediate increases in Vbr (average +34%) and Cbr (+63%) that reached a maximum approximately 7 s after the injection.

Positive_regulation (increases) of Cbr associated with heart rate under development, pressure volume 2 under development, qutenza and sleep disorders

3) Confidence 0.10 Published 1992 Journal J. Appl. Physiol. Section Abstract Doc Link 1559957 Disease Relevance 0.43 Pain Relevance 0.40

A second increase in Vbr, but not in Cbr, occurred approximately 12 s later, coinciding with an increase in Pa.

Positive_regulation (increase) of Cbr

4) Confidence 0.08 Published 1992 Journal J. Appl. Physiol. Section Abstract Doc Link 1559957 Disease Relevance 0.42 Pain Relevance 0.39

The primary end point was the number of patients categorized as having a CBR or stable CBR (SCBR) during the first three treatment cycles.

Positive_regulation (having) of CBR

5) Confidence 0.03 Published 2008 Journal J. Clin. Oncol. Section Body Doc Link 18669455 Disease Relevance 0.08 Pain Relevance 0

The primary end point was the number of patients categorized as having a CBR or stable CBR (SCBR) during the first three treatment cycles.

Positive_regulation (having) of CBR

6) Confidence 0.02 Published 2008 Journal J. Clin. Oncol. Section Body Doc Link 18669455 Disease Relevance 0.08 Pain Relevance 0

General Comments

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