INT11418

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Context Info
Confidence 0.14
First Reported 1992
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 1.82
Pain Relevance 1.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Cbr1) oxidoreductase activity (Cbr1) plasma membrane (Cbr1)
nucleus (Cbr1) cytoplasm (Cbr1)
Cbr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 16 98.14 Very High Very High Very High
c fibre 8 78.80 Quite High
Pain 4 10.00 Low Low
Analgesic 2 10.00 Low Low
palliative 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pressure Volume 2 Under Development 4 99.64 Very High Very High Very High
Heart Rate Under Development 4 99.30 Very High Very High Very High
Sleep Disorders 4 99.04 Very High Very High Very High
Increased Venous Pressure Under Development 8 95.52 Very High Very High Very High
Biliary Cancer 4 76.84 Quite High
Cancer 2 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Results after atropine indicated that the immediate increases in Vbr and Cbr were mainly cholinergic.
Positive_regulation (increases) of Cbr
1) Confidence 0.14 Published 1992 Journal J. Appl. Physiol. Section Abstract Doc Link 1559957 Disease Relevance 0.40 Pain Relevance 0.34
Vagal cooling (0 degrees C) prevented the pulmonary chemoreflex; it also abolished the immediate increases in Vbr and Cbr in four of six sheep and substantially reduced them in two sheep; it did not affect the late increases in Vbr and Pa.
Positive_regulation (increases) of Cbr
2) Confidence 0.14 Published 1992 Journal J. Appl. Physiol. Section Abstract Doc Link 1559957 Disease Relevance 0.41 Pain Relevance 0.36
Right atrial injection of capsaicin evoked a prompt pulmonary chemoreflex (apnea, bradycardia, and hypotension), with immediate increases in Vbr (average +34%) and Cbr (+63%) that reached a maximum approximately 7 s after the injection.
Positive_regulation (increases) of Cbr associated with heart rate under development, pressure volume 2 under development, qutenza and sleep disorders
3) Confidence 0.10 Published 1992 Journal J. Appl. Physiol. Section Abstract Doc Link 1559957 Disease Relevance 0.43 Pain Relevance 0.40
A second increase in Vbr, but not in Cbr, occurred approximately 12 s later, coinciding with an increase in Pa.
Positive_regulation (increase) of Cbr
4) Confidence 0.08 Published 1992 Journal J. Appl. Physiol. Section Abstract Doc Link 1559957 Disease Relevance 0.42 Pain Relevance 0.39
The primary end point was the number of patients categorized as having a CBR or stable CBR (SCBR) during the first three treatment cycles.
Positive_regulation (having) of CBR
5) Confidence 0.03 Published 2008 Journal J. Clin. Oncol. Section Body Doc Link 18669455 Disease Relevance 0.08 Pain Relevance 0
The primary end point was the number of patients categorized as having a CBR or stable CBR (SCBR) during the first three treatment cycles.
Positive_regulation (having) of CBR
6) Confidence 0.02 Published 2008 Journal J. Clin. Oncol. Section Body Doc Link 18669455 Disease Relevance 0.08 Pain Relevance 0

General Comments

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